Szerző szerinti böngészés "Anjou, Tarek"

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    Domino Knoevenagel-cyclization reactions for the preparation of pyridine-containing condensed heterocycles
    Anjou, Tarek; Kurtán, Tibor; Sándor, Király; DE--Természettudományi és Technológiai Kar--Biotechnológiai Intézet
    In this thesis work, the goal was to synthesize chiral condensed O,N-heterocycles by the domino Knoevenagel-hetero Diels-Alder reaction from a 2-H-chromene derivative containing a pyridine-3-carbaldehyde moiety as a starting material. Eight new condensed chiral O,N-heterocycles were successfully synthesized and analyzed by NMR, no other ring closure mechanism was observed in these reactions. The synthesized compounds are to be studied in anti-proliferative activity assays against various cancer cell lines to compare activity with the previously synthesized benzenecondensed analogues.