Osteoporosis in patients with SLE has been widely studied in the last 2 decades, but most of the series have focused on women. Some of these studies have included a limited number of men with SLE. Bone Mineral Density in Women with Systemic Lupus Erythematosus Our results show reduced trabecular bone mass, as a higher percentage of our patients were osteopenic at the lumbar spine (LS) as compared to that at the femur neck (FN). Further, LS BMD correlated well with both cumulative and daily steroid doses. Prevalence of reduced bone mass at LS is pronounced among postmenopausal SLE women, in those with high Steinbrocker functional classification and those on high daily steroid dose. Therefore, these patients should be considered as a high-risk group deserving regular spine BMD scans and therapy in due time to prevent vertebral fractures. Bone Mineral Density and Hormonal Status in Men with Systemic Lupus Erythematosus We found no difference in BMD at LS, FN, ultra-distal radius (RUD) and mid-33% radius (R33%) between SLE men and control group. Our laboratory results showed that the mean bone specific alkaline phosphatase, osteocalcin, serum and urinary crosslaps were in the normal reference range. We found no correlation between the biochemical markers of bone turnover and BMD. We found a high prevalence of hypovitaminosis D (65.2%), hypotestosteronism (62.5%) and hypodehydroepiandrosterone-sulphate (100%). But despite the fact that our study includes the highest number of SLE men with a higher mean age, SLEDAI, cumulative steroid dose and longer mean disease duration than earlier studies, we did not observe a lower bone mass in our patients as compared to the controls.