Pórszász, RóbertSavani, Vandan2021-05-162021-05-162020-07http://hdl.handle.net/2437/309672Histone deacetylase inhibitors are powerful epigenetic modifiers, altering gene expression and on a larger aspect, the fate of individual cells. The Food and Drugs Administration has approved the use of four new HDIs, bringing about a revolutionary dawn in modern day clinical oncology. This thesis focuses on; HDAC roles in tumour propagation, properties of HDIs and novel HDI drugs.33enhistonehistone deacetylasecancerDEENK Témalista::Orvostudomány::Farmakológia