A review of the study of the effectiveness of drug candidate BGP-15 in delaying diastolic dysfunction in the Goto-Kakizaki rat model of diabetic cardiomyopathy

Juhász, BélaHollos, Nora2021-06-172021-06-172020http://hdl.handle.net/2437/311250Review of a current study to compare the drug candidate, BGP-15, to metformin and pioglitazone. The aim was to observe whether BGP-15 had any cardiovascular effects on Goto-Kakizaki (GotoK) rats. The reason for this is to find an alternative, enhanced treatment for diabetic cardiomyopathy that has a better side effect profile and is more effective than current antidiabetic medication. In the study, BGP-15 was found to restore diastolic function in GotoK rats. Metformin and pioglitazone had no significant effect on echocardiographic parameters.40enBGP-15Diastolic dysfunctionA review of the study of the effectiveness of drug candidate BGP-15 in delaying diastolic dysfunction in the Goto-Kakizaki rat model of diabetic cardiomyopathyDEENK Témalista::Orvostudomány::Farmakológia