Pórszász, RóbertKaya, Kasim Ferhat2018-08-022018-08-022017-07-18http://hdl.handle.net/2437/255928In this thesis, there is an overall review of some malignant disease theories, e.g. the problem of circulating tumor cells and cancer cell dormancy. The importance of tumor microenvironment is explained, thus the logic of immunotherapy. A detailed description can be read about the CTLA-4 checkpoint pathway and the PD-1 checkpoint pathway. The therapies in focus are the immune checkpoint inhibitors. Finally, some future treatment perspectives can be read.41enSomatic mutation theoryTissue organization field theoryAtavistic modelCirculating tumor cellsCancer cell dormancyImmune checkpointsCTLA-4 checkpoint pathwayPD-1 checkpoint pathwayImmune checkpoint inhibitorsDEENK Témalista::Orvostudomány