Kurtán, TiborEmara, Fatma2024-12-172024-12-172024-11-15https://hdl.handle.net/2437/383189My thesis explores the synthesis of 6-iodo-4’-(trifluoromethyl)-7,8-benzoflavanone, focusing on its potential as aromatase inhibitor to aid in breast cancer treatment. The thesis outlines two synthetic pathways: microwave-assisted and base-catalyzed, each employing multiple reaction steps to optimize yields and reaction efficiency. Starting from hydroxyacetophenone derivatives, the synthetic process includes key steps like Friedel-Crafts acylation, Claisen-Schmidt condensation, and cyclization, achieving varying yields across methods, structures were confirmed using NMR spectroscopy. The study emphasizes the microwave-assisted approach for its efficiency and reduced reaction time, aligning with green chemistry principles. Ultimately, the synthesized benzoflavanone derivatives serve as standards for stereoselective reactions, with successful enantioselectivity applications promising for drug development.30enFlavanonesAromatase inhibtionMicrowave-assisted synthesisBase-catalyzed synthesisCyclizationEnantioselectivityChemistryHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.