Székvölgy, LórántGigauri, Nata2026-06-112026-06-112026-06-09https://hdl.handle.net/2437/409429This Master's thesis explores the important relationship between cancer metabolism and genome stability. Specifically, the research investigates how the IDO1 enzyme influences the regulation of R-loops, which are unique DNA-RNA structures that can affect overall DNA stability. To test the hypothesis, laboratory experiments were conducted using two different breast cancer cell lines. These cells were analyzed using a combination of global R-loop detection and a specialized molecular technique called DRIP-qPCR. The findings provide new and meaningful insights into how IDO1-related metabolic pathways impact the genome. Overall, this study builds a solid foundation for future research aiming to better understand the underlying biology of cancer.34enR-loopsIDO1Dot blotDRIP-qPCRCancer metabolismGenomic instabilityBiology::Molecular BiologyHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.