Virág, LászlóOladapo, Emmanuel Taiwo2021-08-182021-08-182021-07-26http://hdl.handle.net/2437/321301The PARP enzyme family is a heterogeneous group of enzymes that are involved in a myriad of intracellular processes from maintaining genomic integrity, modulating inflammatory responses, and regulating cellular metabolism, to name a few. PARP 1 and 2 especially are crucial in the detection and repair of DNA lesions. This function of PARPs has made them interesting targets for pharmaceutical modulation for the purpose of treating malignant tumours. Since malignant tumours have a relatively higher rate of DNA mutations coupled with frequently dysfunctional DNA repair systems.32enPARP inhibitorsCancer therapyPARP enzymesDNA repairDEENK Témalista::Orvostudomány::Orvosi vegytanDEENK Témalista::Orvostudomány::Onkológia