Pórszász, RóbertPatel, Pooja Sundip2019-09-252019-09-252019-04-25http://hdl.handle.net/2437/273744Chronic inflammation is a slow, long term inflammation which lasts for a prolonged period, with a range from several months to years, which has now been ranked as one of the single greatest threats to human health by the World Health Organisation (WHO).In inflammatory conditions, COX-2 is increasingly produced by cytokines, growth factors and bacterial endotoxin, its enzymatic activity accounts for a large number of PGs produced during inflammation. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are nonselective inhibitors for both COX isoforms. Inhibition of COX-2 leads to therapeutic inhibition of the synthesis of proinflammatory PGs, however, this inhibition can lead to side effects. New pharmaceutical drugs which are highly selective COX-2 inhibitors, celecoxib, etoricoxib, and diclofenac, have shown to be as effective as NSAIDs with reduced side effects on various chronic inflammatory diseases, for example, rheumatoid arthritis, COPD, Parkinson, Alzheimer’s, Cardiovascular Diseases et cetera.37enCyclooxygenaseCyclooxygenase 1Cyclooxygenase 2Nonsteroidal anti-inflammatory drugsProstaglandinProstacyclinInflammationChronic DiseasesAcute InflammationChronicDEENK Témalista::Orvostudomány::Farmakológia