Máthé, EndreChoudhury, Hoimonti2025-06-192025-06-192025-05-06https://hdl.handle.net/2437/393598This research study is a step forward in bridging the gap between the ancient Ayurvedic formulations, which are essentially what we today call “nutraceuticals” and the need for scientific validation of its efficacy in order to achieve universal recognition and acceptability. Two ayurvedic samples (SAM1 and SAM2) generally known for its anti-diabetic effects were investigated in this study. These were assessed for the following parameters: a) Quality- through investigation of nutritional capacity using Drosophila melanogaster-based model and quantitative analysis of the Total Phenolic Compounds (TPC), Total Flavonoid Compounds (TPC) and antioxidant properties b) Safety- through investigation of its toxic effects on Drosophila viability c) Efficacy- through investigation of its rescue effect on High Sugar diet-induced stress and study of Position Effect Variegation to know its epigenetic influence. Presence of TPC, TFC and antioxidant properties were detected and quantified in both samples. Both samples showed health enhancing effects and had an epigenetic influence on the expression of the white gene in white mottled (wm4h) strain of Drosophila melanogaster.58enDrosophilaAyurvedaNutraceuticalAntioxidantEpigeneticAgricultural SciencesHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.