Synthesis of multivalent glycomimetics, carbohydrate-containing chimeras and antibiotics with potential biological relevance

Magdolna, CsávásLe, Son2022-06-282022-06-282022http://hdl.handle.net/2437/335682Antibiotic resistance is an alarming multifaceted problem, and it is predicted to be one of the greatest threats to human health in the next few decades. Once antibiotic resistance is allowed to continue uncontrollably, we may enter a ‘post-antibiotic era’ of medicine, in which even a minor infection may become lethal. In the light of this global problem, we aimed to tackle ABR through three approaches including building multivalent glycomimetics, developing chimeric antibiotics, and modifying mutilin-type antibiotics.105enantibiotic resistanceantiadhesivelectinlectin inhibitorsmultivalentsglycomimeticsquinolonepleuromutilinchimeric antibioticnovel therapypharmaceutical chemistrySynthesis of multivalent glycomimetics, carbohydrate-containing chimeras and antibiotics with potential biological relevancePhD, doktori értekezésSynthesis of multivalent glycomimetics, carbohydrate-containing chimeras and antibiotics with potential biological relevanceGyógyszertudományokOrvostudományok