Sándor, KirályAnjou, TarekKurtán, Tibor2022-11-112022-11-112022-11-10https://hdl.handle.net/2437/339476In this thesis work, the goal was to synthesize chiral condensed O,N-heterocycles by the domino Knoevenagel-hetero Diels-Alder reaction from a 2-H-chromene derivative containing a pyridine-3-carbaldehyde moiety as a starting material. Eight new condensed chiral O,N-heterocycles were successfully synthesized and analyzed by NMR, no other ring closure mechanism was observed in these reactions. The synthesized compounds are to be studied in anti-proliferative activity assays against various cancer cell lines to compare activity with the previously synthesized benzenecondensed analogues.33enHeterocyclesDomino reactionsAntiproliferativeDEENK Témalista::Kémia::Szerves kémia