Theses (Faculty of Medicine)
Állandó link (URI) ehhez a gyűjteményhez
Theses collection of the Faculty of Medicine. The collection was started in 2014.
At the University of Debrecen, in accordance with the 2022 amendment to the 2011 Higher Education Act, student theses are only accessible from devices connected to the University's Eduroam WiFi network or from a university IP address.
“The thesis or diploma work of a student who has successfully passed the final examination shall be stored in full in the academic system of the higher education institution, and a record shall be maintained thereof. The stored theses and diploma works – with the exception of parts classified as confidential in accordance with the relevant legislation – must be made accessible and searchable without restriction through the academic system.” Further info on the National Higher Education Act in Hungarian: Felsőokt. tv. (új) - 2011. évi CCIV. törvény a nemzeti felsőoktatásról - Hatályos Jogszabályok Gyűjteménye.
Böngészés
legfrissebb feltöltések
Megjelenítve 1 - 20 (Összesen 1875)
Tétel Korlátozottan hozzáférhető Immunotherapy of Non-Small Cell Lung Cancer (NSCLC)Kairy, Dor; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetImmunotherapy of Non-Small Cell Lung Cancer (NSCLC)Tétel Korlátozottan hozzáférhető Modern Pharmacological Treatment Of DiabetesNavick, Amit; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dóra; Szentmiklósi, József; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetMy thesis is dealing with the different types of diabetes, their symptoms, risk factors, diagnostic criteria and complications. In addition it is focusing on the different pharmacotherapies and its application on different populations.Tétel Korlátozottan hozzáférhető Photodynamic Therapy of Acne and Acne ScarsTan , Jingqian; Gellén, Emese; Általános Orvostudományi Kar::Bőrgyógyászati Tanszék; DE--Általános Orvostudományi Kar; Sawhney, Irina; Pethó, Zsófia; Általános Orvostudományi Kar::Bőrgyógyászati Tanszék; Általános Orvostudományi Kar::Belgyógyászati Intézet::Reumatológiai TanszékThis thesis reviews the clinical evidence of photodynamic therapy (PDT) for acne vulgaris and acne scars, focusing on its efficacy, mechanisms, and safety. PDT improves acne by reducing inflammation, suppressing sebum production, and eliminating Cutibacterium acnes. It also benefits acne scars by promoting tissue regeneration, reducing hyperpigmentation, and regulating collagen synthesis. However, its effectiveness for severe scars is limited and often requires combination with other treatments. The review also compares different photosensitizers and light sources to optimize therapy. Overall, PDT is a safe and effective option, though further standardization is needed for consistent clinical use.Tétel Korlátozottan hozzáférhető The Impact of Non-Specific Skills on Endoscopic TraningNyante, Hugh; Farkas, Zsolt; Általános Orvostudományi Kar::Szülészeti és Nőgyógyászati Intézet; DE--Általános Orvostudományi Kar; Porszász, Róbert; Jashanjeet, Singh; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Szülészeti és Nőgyógyászati IntézetThe thesis examines the impact of non-specific skills such as psychomotor ability, spatial awareness, and cognitive adaptability on the acquisition of endoscopic skills within a dry laboratory training environment. It employs an experimental design comparing novice participants and medical residents,by grouping them by their level of non-specific skills and assessing performance through repeated laparoscopic tasks using time based metrics. The findings demonstrate that individuals with higher levels of non-specific skills perform tasks more efficiently, achieve faster completion times, and reach performance plateaus earlier than those with lower skill levels. Although medical residents show superior overall performance due to prior experience, novices with strong non-specific skills exhibit steeper learning curves, indicating rapid adaptability. The study highlights the significant role of non-specific skills in accelerating skill acquisition and improving consistency in endoscopic training. It concludes that integrating non-specific skill development into medical training and utilizing dry skills laboratories can enhance learning outcomes and improve procedural safety.Tétel Korlátozottan hozzáférhető New Frontiers in Lipid Management: The Role of Inclisiran in Cardiovascular Risk ReductionGabr, Mariem Wael Mohamed Abdelrahman; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetCardiovascular disease remains the leading cause of global mortality, with elevated LDL cholesterol identified as a key modifiable risk factor. Despite the availability of statins and other lipid lowering therapies, a significant proportion of high risk patients fail to reach guideline recommended LDL-C targets due to variable reasons. With continued research, novel therapeutic approaches targeting the PCSK9 pathway have emerged, most notably Inclisiran, the first approved siRNA based lipid lowering therapy. This thesis was written to review the biology of lipid metabolism and PCSK9, the mechanism of action of Inclisiran via RNA interference and hepatocyte selective delivery, and its clinical efficacy and safety as established through the ORION trial program, with a focus on its positioning relative to existing lipid lowering therapies as a potentially transformative advancement in cardiovascular risk management.Tétel Korlátozottan hozzáférhető Pharmacological Management of Opioid Use DisorderAbdalla, Rayana; Varga, Balázs; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Gesztelyi, Rudolf; Fenyvesi, Ferenc; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Gyógyszerésztudományi KarOpioid use disorder (OUD) remains a complex and escalating public health crisis, particularly in North America, driven by both historical overprescribing and the widespread availability of synthetic opioids such as fentanyl. This thesis critically examines the pharmacological management of OUD, focusing on the mechanisms, pharmacokinetics, and clinical application of methadone, buprenorphine, and naltrexone. Comparative analysis highlights important differences in safety, treatment retention, and accessibility, emphasizing the clinical advantages of opioid agonist therapies. Emerging therapies are also explored, though current evidence supports their role primarily as adjunctive options. Overall, this work underscores the importance of individualized treatment strategies and the integration of harm reduction approaches in improving patient outcomes.Tétel Korlátozottan hozzáférhető Management of neuromuscular blockade in paediatric patientsYousef Hussein Mustafa , Rasha; Mena Ajeeb , Boktor; Általános Orvostudományi Kar::Aneszteziológiai és Intenzív Terápiás Tanszék; DE--Általános Orvostudományi Kar; Gál, Judit; Fekete, Gábor Zoltán; Általános Orvostudományi Kar::Aneszteziológiai és Intenzív Terápiás Tanszék; Általános Orvostudományi Kar::Idegsebészeti KlinikaThis thesis highlights the history of anaesthesia, the challenges anaesthesiologists face, and the current guidelines for the management of NMBAs in paediatric patients. Emphasising the pharmacokinetic and pharmacodynamic differences between adult and paediatric patients. It also discusses commonly used NMBAs. It reviews the role of neuromuscular monitoring techniques, including acceleromyograph and electromyography, in minimising residual neuromuscular blockade. Additionally, the thesis explores the evolving role of reversal agents, such as sugammadex, compared to the regularly used anticholinesterasesTétel Korlátozottan hozzáférhető Pharmacology of Ganoderma lucidumSakamoto, Ryoya; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetPharmacological characteristics of Ganoderma lucidum nutrients were listed up and discussed. Specific components are as follow; polysaccharides, triterpenes, cerebrosides, peptides and polyphenols. Beneficial functions of each components were listed up. Anti-proliferative, immunomodulatory, antioxidative, anti-cancer, anti-microbial and anti-insomnia effects of the mushroom were discussed. Extracts of the mushroom may function as beneficial medicine, but there are few data of the effect of Ganoderma lucidum against human.Tétel Korlátozottan hozzáférhető Toxicological Investigation of Suicide Cases in Hungary and JapanSanada, Kazuki; Ráccz, Kálmán; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; DE--Általános Orvostudományi Kar; Pórszász, Róbert; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis examines the toxicological characteristics of suicide in Hungary and Japan, focusing on the substances involved and how patterns differ between the two countries. It shows that in Hungary, medication overdose—especially involving benzodiazepines, antidepressants, and antipsychotics—is the primary toxicological cause of suicide, often exacerbated by alcohol use. In contrast, Japan demonstrates a prominent role of gaseous methods such as carbon monoxide and hydrogen sulfide, although medication overdoses remain significant. The study highlights how cultural, social, and healthcare system differences—such as prescribing practices and access to means—influence suicide methods. It also identifies major challenges in forensic toxicology, including limited autopsy rates and difficulties in interpreting postmortem findings. Finally, the thesis proposes prevention strategies, emphasising safer prescribing, alcohol control, improved toxicological investigation, and coordinated public health interventions to reduce suicide mortality.Tétel Korlátozottan hozzáférhető Targeting Tau protein in Alzheimer's Disease: emergign pharmacological approachesIizuka, Yukiho; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis is a literature review thesis about the emerging tau-targeted approaches in the treatment of Alzheimer's disease. Currently available conventional therapy only brings the symptomatic relief to the patients. However, the emerging tau-targeted approaches are focused due to its disease modifying potentials. Tau-targeted therapy can be divided into 3 categories, enzyme targeted therapy, tau aggregation therapy, and immunotherapy. this review also describes the limitation in the clinical translation of those approaches from experimental reserach.Tétel Korlátozottan hozzáférhető Contraceptives as Comprehensive Health CareKodama, Asuka; Varga, Balázs; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Kozma, Bence; Erdei, Tamás; Általános Orvostudományi Kar::Szülészeti és Nőgyógyászati Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis thesis explores oral contraceptive pills (OCPs) as both medical treatments and tools that influence women’s health, autonomy, and quality of life. It explains their pharmacological mechanisms, including how hormonal components prevent ovulation and create multiple barriers to fertilization, while also highlighting differences in formulations and delivery methods. Beyond contraception, the study emphasizes their therapeutic benefits, such as regulating menstrual cycles, improving conditions like acne and PCOS, and enhancing psychological well-being. The thesis also examines how cultural, systemic, and educational factors shape contraceptive use, with a particular comparison between Japan and Western countries, showing that access and social attitudes significantly affect uptake. It argues that OCPs should be viewed not only as birth control but as comprehensive healthcare tools that support reproductive autonomy and public health. Finally, the study calls for improved accessibility, better education, and more inclusive research to advance equitable contraceptive care worldwide.Tétel Korlátozottan hozzáférhető Adhd medications: Past, present, the future.Abdelmonem Hassan, Mohamed Khaled Mohamed; Pórszász , Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dóra; Megyeri, Attila; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis thesis discusses a common, multifactorial disorder called Attention Deficit Hyperactivity Disorder (ADHD), a neurodevelopmental disorder characterized by persistent patterns of inattention, hyperactivity, and impulsivity. It reviews the evolution of knowledge about ADHD, from explanations related to behavioral disorders to the modern view of it as a brain disorder with strong genetic roots. The article also discusses its association with polygenic risk factors, along with environmental factors that interact to disrupt the regulation of catecholamine systems (dopamine and norepinephrine). Furthermore, it examines the relationship between ADHD and differences in prefrontal and default mode brain networks, which are responsible for executive functions and attention. Diagnosis of ADHD is primarily based on clinical and behavioral assessments, but it is also influenced by self-assessment, developmental variability, and sociodemographic biases, highlighting the need for objective diagnostic biomarkers. Current treatments (particularly stimulants and non-stimulants) are relatively effective in alleviating core symptoms by increasing catecholamine signaling, leading to positive functional effects. However, patient responses to different treatments vary considerably. These variations depend primarily on pharmacokinetics, pharmacogenomics, patient age and health status, and common comorbidities.Tétel Korlátozottan hozzáférhető Pharmacological Background of Doping: Beyond Performance Enhancing Evidence in the WADA Prohibited ListKusumi, Masaki; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetWhile the WADA Prohibited List is ostensibly grounded in scientific evidence of performance enhancement, many listed substances actually lack robust clinical support within elite competitive contexts. Discrepancies between official analytical findings and estimated prevalence rates suggest that both detection statistics and research methodologies face significant structural constraints. Crucially, the World Anti-Doping Code prohibits substances based not only on ergogenic potential, but also on health risks and normative concepts like the "spirit of sport." This approach frames anti-doping as a complex risk-management and ethical framework rather than a simple pharmacological hierarchy. Ultimately, the Prohibited List functions as a hybrid regulatory instrument that intentionally balances pharmacology, institutional legitimacy, and the broader goal of athletic fairness.Tétel Korlátozottan hozzáférhető Pharmacological Overview of Chinese Traditional MedicineKigawa, Chiaki; Pórszász, Ròbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis provides a pharmacological overview of Traditional Chinese Medicine (TCM), focusing on its historical background, theoretical principles, major herbal medicines, and modern clinical applications. Traditional Chinese Medicine has been practiced for thousands of years and remains an important component of complementary and integrative medicine worldwide. The thesis reviews commonly used medicinal herbs and classical formulas, with particular attention to their active compounds, mechanisms of action, and therapeutic effects supported by modern pharmacological research. In addition, current scientific evidence, safety considerations, and potential adverse effects are discussed. By integrating traditional medical theory with modern biomedical knowledge, this study aims to improve understanding of how TCM can contribute to contemporary healthcare. The findings highlight both the therapeutic potential and the limitations of herbal medicine, emphasizing the importance of evidence-based evaluation in clinical practice.Tétel Korlátozottan hozzáférhető Assessment of Rehabilitation Strategies for Ankle Sprain and Effectiveness When Returning to SportTakase, Konosuke; Szántó, Sándor; Általános Orvostudományi Kar::Sportorvosi Tanszék; DE--Általános Orvostudományi Kar; Hamar, Attila; Pethő, Zsófia; Általános Orvostudományi Kar::Sportorvosi Tanszék; Általános Orvostudományi Kar::Belgyógyászati Intézet::Reumatológiai TanszékAnkle sprains are among the most common injuries in sports and are frequently associated with recurrent instability and prolonged functional deficits. The aim of this thesis was to review conservative rehabilitation strategies for lateral ankle sprain and to evaluate their effectiveness in relation to return to sport. A structured literature search was performed using PubMed, Scopus, and Web of Science, and 27 relevant studies were included in the final analysis. The findings indicate that proprioceptive and balance training significantly reduce reinjury risk, while strength training and neuromuscular rehabilitation improve functional stability and performance. Manual therapy may contribute to improved range of motion and pain reduction when used as part of a comprehensive rehabilitation program. Overall, multimodal rehabilitation approaches appear to provide the most effective support for safe and sustainable return to sport after ankle sprain.Tétel Korlátozottan hozzáférhető Innovations in HF pharmacotherapy: The use of ARNIAbe, Kei; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dóra; Szentmiklósi, József; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis thesis offers a comprehensive analysis of heart failure (HF) pharmacotherapy, emphasizing the transformative role of angiotensin receptor–neprilysin inhibitors (ARNIs), particularly sacubitril/valsartan, in managing heart failure with reduced ejection fraction (HFrEF). It effectively traces the historical evolution from symptomatic treatments to mechanism-based strategies targeting neurohormonal dysregulation. Central to the discussion is the “Fantastic Four” drug regimen—ARNIs, β-blockers, MRAs, and SGLT2 inhibitors—whose synergistic use has been shown to significantly improve mortality and morbidity. The thesis integrates mechanistic insights with evidence from landmark trials such as PARADIGM-HF and PIONEER-HF, demonstrating both efficacy and safety of ARNI therapy. It also explores the expanding potential of these therapies in HFpEF and pediatric populations. Overall, this work presents a well-structured and evidence-based perspective on modern HF treatment, underscoring the clinical impact of ARNI-based strategies.Tétel Korlátozottan hozzáférhető Pharmacological management of bronchial asthma focusing on biological treatmentYoshikawa, Takahide; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi, Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetBronchial asthma is a chronic inflammatory airway disease characterized by variable symptoms and reversible airflow limitation. In recent years, biologic therapies have emerged as an important treatment option, particularly for patients with severe or therapy-resistant asthma. The aim of this thesis was to review current pharmacological treatment strategies for asthma, with a focus on the clinical role and effectiveness of biologic therapy. The review was based on international clinical guidelines and recent randomized controlled trials published between 2018 and 2025. Biologic agents targeting IgE, IL-5, IL-4 receptor, and TSLP have shown significant reductions in exacerbation rates, oral corticosteroid dependence, and symptom burden in selected patient populations. Treatment response appears to correlate with biomarkers such as blood eosinophil count, IgE levels, and fractional exhaled nitric oxide (FeNO). In conclusion, biologic therapy represents a major advancement in asthma management. Appropriate patient selection and a biomarker-guided approach are key to achieving optimal outcomes.Tétel Korlátozottan hozzáférhető The pharmacological management of inflammatory diseases : Comparing NSAIDs with novel anti-inflammatory agentsHong, Sun Ho; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis reviews the pharmacological management of inflammatory diseases by comparing traditional non-steroidal anti-inflammatory drugs (NSAIDs) with novel targeted anti-inflammatory agents. It outlines key inflammatory pathways and mediators, including cyclo-oxygenase-derived prostaglandins and major cytokine signaling networks. NSAIDs are discussed in terms of mechanical of action, clinical indications, and limitations related to gastrointestinal, renal and cardiovascular adverse effects. The thesis then summarizes newer therapies such as biological targeting TNF-alpha and interleukin pathways, as well as Janus kinase (JAK) inhibitors. Their benefits in disease control and prevention of structural damage are contrasted with safety considerations, monitoring requirements, and cost. Overall, NSAIDs remain first line for acute pain and short term inflammatory symptoms, whereas targeted therapies are preferred for chronic immune mediated diseases requiring sustained disease modification.Tétel Korlátozottan hozzáférhető antidepressant pharmacological approaches to treatment-resistant depressionCho, Habin; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetTreatment-resistant depression (TRD) is a severe form of depression that does not respond to standard antidepressant treatments. This thesis reviews pharmacological strategies for TRD, with emphasis on novel antidepressant and combination therapies. Emerging treatments such as ketamine, esketamine, zuranolone, and psilocybin may improve treatment outcomes in patients with TRD.Tétel Korlátozottan hozzáférhető The Role of Acupuncture and Chinese Herbal Formulas in Managing Sleep Disorders Compared to Western Sleeping PillsCHEN, HSI AN; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetCHM and Acupuncture offer stable, long-term efficacy without the risk of dependence or withdrawal symptoms. TCM modalities are superior for elderly patients and those with chronic insomnia due to fewer adverse events. Combining TCM with Western medicine can enhance therapeutic outcomes and reduce drug dosage.