Theses (Faculty of Medicine)
Állandó link (URI) ehhez a gyűjteményhez
Theses collection of the Faculty of Medicine. The collection was started in 2014.
At the University of Debrecen, in accordance with the 2022 amendment to the 2011 Higher Education Act, student theses are only accessible from devices connected to the University's Eduroam WiFi network or from a university IP address.
“The thesis or diploma work of a student who has successfully passed the final examination shall be stored in full in the academic system of the higher education institution, and a record shall be maintained thereof. The stored theses and diploma works – with the exception of parts classified as confidential in accordance with the relevant legislation – must be made accessible and searchable without restriction through the academic system.” Further info on the National Higher Education Act in Hungarian: Felsőokt. tv. (új) - 2011. évi CCIV. törvény a nemzeti felsőoktatásról - Hatályos Jogszabályok Gyűjteménye.
Böngészés
legfrissebb feltöltések
Megjelenítve 1 - 20 (Összesen 1897)
Tétel Korlátozottan hozzáférhető Dexmedetomidine in Anaesthesia: Pharmacological Mechanisms and Expanding Clinical rolesAbdelrazek, Tasnim Nasreldin; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetAnesthetic practice has traditionally relied on GABAergic agents, which induce deep unconsciousness but often impair breathing and delay cognitive recovery. Dexmedetomidine offers an alternative by targeting alpha-2 adrenergic receptors in the Locus Coeruleus, producing a biomimetic, sleep-like state that preserves cooperation and reduces the need for opioids and volatile anesthetics, thereby lowering postoperative nausea and delirium. Recent research highlights its organ-protective effects, showing it can shield the brain, heart, and kidneys from ischemia-reperfusion injury through molecular mechanisms such as regulating autophagy and inhibiting the NLRP3 inflammasome. However, its sympatholytic action can cause bradycardia and hypotension, so its use is best tailored to high-risk cases where organ protection outweighs cardiovascular risks.Tétel Korlátozottan hozzáférhető SGLT2 Inhibitors in Diabetes Management: Cardioprotective and Renoprotective BenefitsTaimova, Shynar; Pórszász , Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, A. József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis examines how sodium–glucose cotransporter-2 (SGLT2) inhibitors have evolved from purely glucose-lowering drugs into agents with important cardiovascular and renal benefits. It outlines the main biological mechanisms underlying these effects, such as changes in renal hemodynamics, energy metabolism, and inflammatory pathways. The work reviews evidence from large clinical trials showing reduced rates of heart failure hospitalization and slower progression of chronic kidney disease. Special attention is given to the clinical impact of these findings in both diabetic and non-diabetic populations. In conclusion, the thesis highlights the growing importance of SGLT2 inhibitors in contemporary cardio-renal-metabolic therapy.Tétel Korlátozottan hozzáférhető Peripheral atherosclerosis and coagulation dynamics in carotid stenosisAyman Yahya, Dinay; Szegedi , István; Lóczi, Linda; Általános Orvostudományi Kar::Neurológiai Tanszék; Általános Orvostudományi Kar::Laboratóriumi Medicina Intézet; DE--Általános Orvostudományi KarCarotid atherosclerosis is a major cause of ischemic stroke, influenced by risk factors such as hypertension, hyperlipidemia, smoking, diabetes, and obesity, which promote vascular dysfunction and plaque progression. While platelet function and atherosclerosis have been extensively studied, the link between atherosclerosis extent and coagulation activation remains unclear. Aim: To investigate the association between carotid stenosis, peripheral atherosclerosis, and hypercoagulability, as assessed by the thrombin generation assay. Methods: In this pilot study, 30 patients from the Department of Neurology without acute thrombotic disease were enrolled. Carotid stenosis was evaluated by Doppler ultrasonography and classified as mild (1–49%) or advanced (50–100%). Peripheral atherosclerosis was assessed using the ankle-brachial index (ABI). Thrombin generation was measured in platelet-free plasma. Demographics, comorbidities, and medication use were recorded. Results: No significant association was found between thrombin generation parameters and carotid stenosis severity. However, patients with advanced stenosis had significantly lower ABI values than those with mild stenosis (left ABI: 1.09 ± 0.18 vs. 0.94 ± 0.19, p = 0.039; right ABI: 1.11 ± 0.17 vs. 0.86 ± 0.19, p = 0.001), suggesting greater systemic atherosclerotic burden. In the mild stenosis group, triglyceride levels inversely correlated with CRP (r = −0.5581, p = 0.0328). Across the entire cohort, peak thrombin and endogenous thrombin potential (ETP) positively correlated with CRP (r = 0.3802, p = 0.0382; r = 0.3753, p = 0.0410). Time to peak also correlated with triglycerides in both the advanced stenosis group (r = 0.653, p = 0.008) and the full cohort (r = 0.501, p = 0.005). Conclusion: These findings suggest that localized carotid atherosclerosis is not directly linked to systemic thrombin generation. Conversely, ABI, reflecting systemic atherosclerotic burden, was significantly associated with advanced carotid stenosis, highlighting its value as a complementary diagnostic tool. The observed correlations indicate a complex interplay among lipid metabolism, inflammation, and coagulation in patients with atherosclerosis.Tétel Korlátozottan hozzáférhető New frontiers innlipid managment: The role of inclisiran in cardiovascular risk reductionEl Hassan, Omar; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet-ASCVD Pathogenesis: Atherosclerotic Cardiovascular Disease remains the leading global cause of death, progressing from initial lipid retention and inflammation to the development of vulnerable plaques susceptible to life-threatening rupture. -Diagnostic Evolution: Beyond basic lipid profiles, modern 2026 clinical assessments now integrate high-sensitivity C-reactive protein (hsCRP), calcium scoring, and ankle-brachial index (ABI) to provide a more comprehensive view of vascular health. -Addressing the Adherence Gap: While traditional statins and ezetimibe are effective, the chronic "adherence gap" of daily oral medications has historically limited the success of long-term risk reduction. -The siRNA Frontier: Inclisiran has revolutionized therapy by utilizing a GalNAc delivery system to enter hepatocytes and leverage the RNA-induced silencing complex (RISC) to stop PCSK9 production at the genetic level. -Clinical Validation: Extensively validated by the ORION trial program, this siRNA therapy provides stable and durable LDL-C reduction through a convenient biannual dosing schedule administered by healthcare providersTétel Korlátozottan hozzáférhető New perspective of antidepressant and antianxiety pharmacological developmentFarkash Lange, Sheli; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis Thesis focuses on the new aspect of pharmacological development for anxiety and depression. It compares traditional drugs for treatment with the old ones. It looks at how can we treat people who have side effect or the existing drugs.Tétel Korlátozottan hozzáférhető Drug Interactions in Cardio-OncologyHassan, Sara Khaled Abdelaal Hassan; Megyeri, Attila; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetAccording to statistics from the Global Burden of Disease (GBD) compare platform, cardiovascular diseases (CVDs) and cancers were the leading causes of patient morbidity and mortality worldwide between 2016 and 2019, measured in Disability Adjusted Life Years (DALYs). Both of these conditions can co-exist in a single patient and are linked to risk factors, such as dyslipidemia and hypertension (HTN). The simultaneous affliction of patients with both conditions mandates the co-administration of cardiac and oncologic drugs, which in turn leads to drug-drug interactions (DDIs), either pharmacodynamic (PD) or pharmacokinetic (PK). These DDIs, as a side effect, promote the development of more risk factors within these patients. In this thesis, I establish and highlight a potential causative link between these DDIs and the increased DALYs associated with CVDs and cancer, demonstrating several examples of combinative regimens that induce specific risk factors, such as HTN. Based on the information reviewed in this paper, the high DALYs in cardio-oncology patients may be partly iatrogenic, caused by DDIs, and further research is mandated to explore better combinative regimens with fewer adverse effects.Tétel Korlátozottan hozzáférhető Comparative analysis of corticosteroid and biologics in managing inflammatory arthritisKIM, GUNN; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetComparative analysis of corticosteroids and biologics in inflammatory arthritis highlights differences in mechanism, efficacy, and safety profiles. Corticosteroids provide rapid symptom relief by broadly suppressing inflammation but are associated with significant long-term side effects. Biologic agents target specific immune pathways, offering improved disease control and reduced structural joint damage. However, biologics are more expensive and carry risks such as infection and immunogenicity. Overall, treatment choice depends on disease severity, patient characteristics, and the balance between short-term benefits and long-term risks.Tétel Korlátozottan hozzáférhető Pharmacological Basis of Postoperative Pain Managementalhosami, abdulrahman; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis delivers a thorough overview of pharmacological strategies for postoperative pain management. It clearly explains the physiological mechanisms of nociception and the body's intense stress response to surgical trauma. It evaluates the mechanisms, benefits, and safety profiles of various analgesics, including NSAIDs, paracetamol, local anesthetics, and opioids. A major strength of the work is its strong emphasis on multimodal analgesia, a strategy that combines different drug classes to maximize pain relief while minimizing opioid-related side effects. Ultimately, the research successfully demonstrates how proactive pain control through protocols like ERAS prevents the transition from acute discomfort to chronic post surgical painTétel Korlátozottan hozzáférhető Pharmacological Differences in the effectiveness of antihypertensive medications among different racial groupsOnyeogo, Ebubechukwu Faith; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara; Szentmiklósi, József; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThe clinical approach to hypertension requires evolution. Previously, cardiovascular medicine has relied heavily on broad demographics to enable treatment. Today, modern epidemiology proves that an individual’s environment, and socioeconomic factors influence health outcomes. While current European guidelines try to bridge the gap by combination therapies. To achieve the best cardiovascular outcomes across a variety of groups, race-based prescribing must give way to personalized precision medicine that uses pharmacogenomics and direct biomarker profiling in the management of hypertension.Tétel Korlátozottan hozzáférhető Novel approaches to non-motor symptoms in Parkinson's disease: Pharmacological treatments for sleep disturbances and cognitive declineHa, Jaeyi; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri , Attila; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis focuses on non-motor symptoms in Parkinson's disease, especially sleep disturbances and cognitive decline. These symptoms significantly affect patients' quality of life but are often under-recognized. Current pharmacological treatments are reviewed, including both established and emerging therapies. Despite some therapeutic advances, current treatments remain limited in effectiveness. The findings highlight the need for early detection and the development of more effective therapeutic strategies to improve patient outcomes.Tétel Korlátozottan hozzáférhető Pharmacological Interventions for Enhancing Mitochondrial Function and Energy Production in AthletesAl Aqrabawi, Laith; Priksz, Dániel; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Varga, Balázs; Pető, Ágota; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Gyógyszerésztudományi Kar::Gyógyszertechnológiai TanszékInvestigation of pharmacotherapeutic agents with the goal of enhancing mitochondrial function, ATP production, and exercise performance in athletes. The agents reviewed include Urolithin A, CoQ10, MitoQ, NMN, Creatine, NR, Elamipretide, Mitochondrial-derived peptides, exercise mimetics, and classical doping agents. The agents Urolithin A, MitoQ, NMN, and Creatine had the clearest human and/or athlete related evidence, although most studies are small and short term. CoQ10 and MitoQ may support oxidative stress reduction and recovery biomarkers, but evidence for direct performance enhancement remains limited. Elamipretide and mitochondrial-derived peptides are not yet practical athlete therapies, although they are promising mechanistic and disease based concept. Overall, mitochondrial-targeted therapy is promising for athletic use, but larger and longer term studies are required, especially with long term safety data and responder analysis.Tétel Korlátozottan hozzáférhető Contraception in the 21st CenturyHaruna, Hafsat Eleojo; Erdődi, Balázs; Általános Orvostudományi Kar::Szülészeti és Nőgyógyászati Intézet; DE--Általános Orvostudományi Kar; Singh, Jashangeet; Szatmári, Szilárd; Általános Orvostudományi Kar::Szülészeti és Nőgyógyászati Intézet; Általános Orvostudományi Kar::Aneszteziológiai és Intenzív Terápiás TanszékThis thesis talks about the history of contraception, the types of contraception used in the 21st century, their efficacy, and side effects. It delves into the issues surrounding contraception today in legislation, social, and cultural contexts. It explains the developments in the 21st century. It also describes newer methods of contraception in development and discusses further development.Tétel Korlátozottan hozzáférhető The Effectiveness of Schema Therapy in Personality DisorderKawasaki, Shiori; Égerházi, Anikó; Általános Orvostudományi Kar::Pszichiátriai Tanszék; DE--Általános Orvostudományi Kar; Fekete, Zita; Morvai, Szabolcs; Általános Orvostudományi Kar::Magatartástudományi Intézet; Általános Orvostudományi Kar::Pszichiátriai TanszékThis thesis evaluates the effectiveness of Schema Therapy (ST) for treating personality disorders by reviewing its theoretical background and existing research. Unlike traditional CBT which focuses on current symptoms, ST targets deep-rooted schemas and modes developed from unmet childhood needs. By analyzing various studies over the past twenty years, this work shows that ST significantly reduces core symptoms and improves patients' daily functioning. These positive outcomes are most proven in borderline personality disorder but also extend to other groups, such as Cluster C disorders. Although there are some methodological limitations in current research, the evidence suggests that ST is a highly valuable treatment that leads to long-term recovery.Tétel Korlátozottan hozzáférhető Comparing the efficacy of ACE Inhibitors and ARBs in treatment of the hypertensionChoi, Jae Young; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetHypertension is a huge health concern around the world and a main reason why people get heart and kidney illnesses. This research looks at how well ACE inhibitors and ARBs work for high blood pressure, by going over what’s been shown in clinical trials, comparing how they stack up against each other, and looking at the results of multiple analyses. Both of these kinds of drugs bring blood pressure down by interfering with the renin-angiotensin-aldosterone system, but they do so in slightly different ways. When doctors have actually used them, ACE inhibitors and ARBs have been found to lower blood pressure by about the same amount, and crucially, lower the chance of heart problems. Plus, both types of medication are good for your kidneys, especially for those with diabetes or long-term kidney disease. On the whole, ACE inhibitors have lots of proof of reducing deaths from heart issues, however ARBs are often equally effective and are easier for people to keep taking, so both are valuable for managing hypertension.Tétel Korlátozottan hozzáférhető Anticoagulation after ischemic stroke: start, restart, or replace — when and what?Ansari, Zoya Surayya Andaleeb; Csiba, László; Általános Orvostudományi Kar::Neurológiai Tanszék; DE--Általános Orvostudományi Kar; Fekete, Klara; Barta, Judit; Általános Orvostudományi Kar::Neurológiai Tanszék; Általános Orvostudományi Kar::Kardiológiai IntézetStroke is the leading cause of acquired disability in adults worldwide, and preventing the recurrence of stroke is a long-standing question in the field of neurology. For cardiogenic stroke, anticoagulation therapy is the most important method of preventing recurrence. We aimed to investigate the similarities and differences between the international guidelines as for the anticoagulation therapy of cardiogenic stroke. These included the America, Canadian, British/Irish and European guidelines. We classified the guidelines by the cardiogenic event and if there was previous therapy.Tétel Korlátozottan hozzáférhető Investigation of testicular ischemia-reperfusion injury in an experimental modelAbdulrahman A.H., Ahmad; Németh, Norbert; Domján, István; Általános Orvostudományi Kar::Sebészeti Műtéttani Tanszék; DE--Általános Orvostudományi Kar; Lesznyák; Általános Orvostudományi KarThis research created a model using rats to look at the changes in blood flow, tiny blood vessels, and tissue damage after a testicle is twisted for one hour. Using a special kind of ultrasound, it was found that blood flow stopped completely when the testicle was twisted and didn't go back to normal even after it was untwisted. The tiny blood vessels in the testicle and the tube that stores sperm were still not working properly a week after the injury. When the tissues were looked at under a microscope, there was a lot of damage, including the tubes that make sperm shrinking and a big decrease in the production of sperm. The study shows that when a testicle is twisted and then untwisted, it can cause damage to the tissue and affect the whole body's blood flow.Tétel Korlátozottan hozzáférhető The Impact of Volatile vs. Intravenous Anesthesia on Postoperative Cognitive DysfunctionSuwabe, Nagi; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis reviews whether volatile anesthesia and propofol-based total intravenous anesthesia differ in their effects on postoperative cognitive dysfunction in elderly patients. Some studies suggest that propofol-based anesthesia may reduce early cognitive decline in selected non-cardiac surgical settings, but results remain inconsistent across different patient populations and procedures. The findings indicate that anesthetic depth, neurophysiologic suppression, and perioperative management may influence postoperative cognitive outcomes more strongly than anesthetic agent alone. Postoperative cognitive dysfunction appears to be multifactorial and influenced by both patient-related and perioperative factors. Overall, anesthetic choice should be considered within a broader perioperative strategy for protecting cognitive function in elderly patients.Tétel Korlátozottan hozzáférhető Use of Histone Deacetylase inhibitors (HDI): Novel advances in cancer treatmentAl Nasser, Mohammad; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetIn conclusion, via regulating gene expression and chromatin structure, HDACs are essential for epigenetic regulation. Their dysregulation is closely linked to the onset and spread of cancer, mainly by enhancing oncogenic pathways and suppressing tumor suppressor genes. These epigenetic changes can be reversed by HDI, which have become useful therapeutic treatments. HDI stimulate the reactivation of genes, trigger apoptosis, arrest the cell cycle, and disrupt several cellular functions needed for tumor survival by increasing histone acetylation. Their anticancer potential is further enhanced by their additional effects on the tumor microenvironment. The clinical uses of HDI in hematological malignancies have shown significant therapeutic benefits even in cases that are resistant to treatment. Combination therapies have shown positive outcomes as well. However, related side effects still exist. In the end, HDI offer a novel method of focusing on the fundamental process of tumor growth, representing a significant progress in the field of epigenetic cancer treatment.Tétel Korlátozottan hozzáférhető Pharmacological Aspects of General AnesthesiaSfaxi, Salma; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetGeneral anesthesia relies on a combination of drugs to achieve hypnosis, analgesia, and immobility during surgery. Key agents such as propofol, sevoflurane, fentanyl, and neuromuscular blockers act through distinct mechanisms, including GABA-A receptor modulation and inhibition of pain pathways via μ-opioid receptors. Muscle relaxants further contribute by interfering with acetylcholine at the neuromuscular junction. The pharmacokinetics of these drugs determine their onset, duration, and recovery profile, while pharmacodynamics influence their clinical effects and potential adverse reactions. Patient-specific factors, such as age, obesity, and comorbidities, play a crucial role in drug selection and dosing. A thorough understanding of these pharmacological principles is essential for safe and effective perioperative management.Tétel Korlátozottan hozzáférhető pharmacological management of common pediatric ophthalmological diseases: myopia, amblyopia, glaucoma, and retinopathy of prematurity.shadpour, shakiba; Varga, Balázs; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Ujhelyi, Bernadett; Juhász, Béla; Általános Orvostudományi Kar::Szemészeti Tanszék; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézetpharmacological and non-pharmacological treatments for padiatric ophthalmological diseases focusing on myopia, amblyopia, glaucoma and retinopathy of prematurity.