Theses (Faculty of Medicine)
Állandó link (URI) ehhez a gyűjteményhez
Theses collection of the Faculty of Medicine. The collection was started in 2014.
At the University of Debrecen, in accordance with the 2022 amendment to the 2011 Higher Education Act, student theses are only accessible from devices connected to the University's Eduroam WiFi network or from a university IP address.
“The thesis or diploma work of a student who has successfully passed the final examination shall be stored in full in the academic system of the higher education institution, and a record shall be maintained thereof. The stored theses and diploma works – with the exception of parts classified as confidential in accordance with the relevant legislation – must be made accessible and searchable without restriction through the academic system.” Further info on the National Higher Education Act in Hungarian: Felsőokt. tv. (új) - 2011. évi CCIV. törvény a nemzeti felsőoktatásról - Hatályos Jogszabályok Gyűjteménye.
Böngészés
legfrissebb feltöltések
Megjelenítve 1 - 20 (Összesen 1866)
Tétel Korlátozottan hozzáférhető Targeting Tau protein in Alzheimer's Disease: emergign pharmacological approachesIizuka, Yukiho; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis is a literature review thesis about the emerging tau-targeted approaches in the treatment of Alzheimer's disease. Currently available conventional therapy only brings the symptomatic relief to the patients. However, the emerging tau-targeted approaches are focused due to its disease modifying potentials. Tau-targeted therapy can be divided into 3 categories, enzyme targeted therapy, tau aggregation therapy, and immunotherapy. this review also describes the limitation in the clinical translation of those approaches from experimental reserach.Tétel Korlátozottan hozzáférhető Contraceptives as Comprehensive Health CareKodama, Asuka; Varga, Balázs; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Kozma, Bence; Erdei, Tamás; Általános Orvostudományi Kar::Szülészeti és Nőgyógyászati Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis thesis explores oral contraceptive pills (OCPs) as both medical treatments and tools that influence women’s health, autonomy, and quality of life. It explains their pharmacological mechanisms, including how hormonal components prevent ovulation and create multiple barriers to fertilization, while also highlighting differences in formulations and delivery methods. Beyond contraception, the study emphasizes their therapeutic benefits, such as regulating menstrual cycles, improving conditions like acne and PCOS, and enhancing psychological well-being. The thesis also examines how cultural, systemic, and educational factors shape contraceptive use, with a particular comparison between Japan and Western countries, showing that access and social attitudes significantly affect uptake. It argues that OCPs should be viewed not only as birth control but as comprehensive healthcare tools that support reproductive autonomy and public health. Finally, the study calls for improved accessibility, better education, and more inclusive research to advance equitable contraceptive care worldwide.Tétel Korlátozottan hozzáférhető Adhd medications: Past, present, the future.Abdelmonem Hassan, Mohamed Khaled Mohamed; Pórszász , Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dóra; Megyeri, Attila; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis thesis discusses a common, multifactorial disorder called Attention Deficit Hyperactivity Disorder (ADHD), a neurodevelopmental disorder characterized by persistent patterns of inattention, hyperactivity, and impulsivity. It reviews the evolution of knowledge about ADHD, from explanations related to behavioral disorders to the modern view of it as a brain disorder with strong genetic roots. The article also discusses its association with polygenic risk factors, along with environmental factors that interact to disrupt the regulation of catecholamine systems (dopamine and norepinephrine). Furthermore, it examines the relationship between ADHD and differences in prefrontal and default mode brain networks, which are responsible for executive functions and attention. Diagnosis of ADHD is primarily based on clinical and behavioral assessments, but it is also influenced by self-assessment, developmental variability, and sociodemographic biases, highlighting the need for objective diagnostic biomarkers. Current treatments (particularly stimulants and non-stimulants) are relatively effective in alleviating core symptoms by increasing catecholamine signaling, leading to positive functional effects. However, patient responses to different treatments vary considerably. These variations depend primarily on pharmacokinetics, pharmacogenomics, patient age and health status, and common comorbidities.Tétel Korlátozottan hozzáférhető Pharmacological Background of Doping: Beyond Performance Enhancing Evidence in the WADA Prohibited ListKusumi, Masaki; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetWhile the WADA Prohibited List is ostensibly grounded in scientific evidence of performance enhancement, many listed substances actually lack robust clinical support within elite competitive contexts. Discrepancies between official analytical findings and estimated prevalence rates suggest that both detection statistics and research methodologies face significant structural constraints. Crucially, the World Anti-Doping Code prohibits substances based not only on ergogenic potential, but also on health risks and normative concepts like the "spirit of sport." This approach frames anti-doping as a complex risk-management and ethical framework rather than a simple pharmacological hierarchy. Ultimately, the Prohibited List functions as a hybrid regulatory instrument that intentionally balances pharmacology, institutional legitimacy, and the broader goal of athletic fairness.Tétel Korlátozottan hozzáférhető Pharmacological Overview of Chinese Traditional MedicineKigawa, Chiaki; Pórszász, Ròbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis provides a pharmacological overview of Traditional Chinese Medicine (TCM), focusing on its historical background, theoretical principles, major herbal medicines, and modern clinical applications. Traditional Chinese Medicine has been practiced for thousands of years and remains an important component of complementary and integrative medicine worldwide. The thesis reviews commonly used medicinal herbs and classical formulas, with particular attention to their active compounds, mechanisms of action, and therapeutic effects supported by modern pharmacological research. In addition, current scientific evidence, safety considerations, and potential adverse effects are discussed. By integrating traditional medical theory with modern biomedical knowledge, this study aims to improve understanding of how TCM can contribute to contemporary healthcare. The findings highlight both the therapeutic potential and the limitations of herbal medicine, emphasizing the importance of evidence-based evaluation in clinical practice.Tétel Korlátozottan hozzáférhető Assessment of Rehabilitation Strategies for Ankle Sprain and Effectiveness When Returning to SportTakase, Konosuke; Szántó, Sándor; Általános Orvostudományi Kar::Sportorvosi Tanszék; DE--Általános Orvostudományi Kar; Hamar, Attila; Pethő, Zsófia; Általános Orvostudományi Kar::Sportorvosi Tanszék; Általános Orvostudományi Kar::Belgyógyászati Intézet::Reumatológiai TanszékAnkle sprains are among the most common injuries in sports and are frequently associated with recurrent instability and prolonged functional deficits. The aim of this thesis was to review conservative rehabilitation strategies for lateral ankle sprain and to evaluate their effectiveness in relation to return to sport. A structured literature search was performed using PubMed, Scopus, and Web of Science, and 27 relevant studies were included in the final analysis. The findings indicate that proprioceptive and balance training significantly reduce reinjury risk, while strength training and neuromuscular rehabilitation improve functional stability and performance. Manual therapy may contribute to improved range of motion and pain reduction when used as part of a comprehensive rehabilitation program. Overall, multimodal rehabilitation approaches appear to provide the most effective support for safe and sustainable return to sport after ankle sprain.Tétel Korlátozottan hozzáférhető Innovations in HF pharmacotherapy: The use of ARNIAbe, Kei; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dóra; Szentmiklósi, József; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis thesis offers a comprehensive analysis of heart failure (HF) pharmacotherapy, emphasizing the transformative role of angiotensin receptor–neprilysin inhibitors (ARNIs), particularly sacubitril/valsartan, in managing heart failure with reduced ejection fraction (HFrEF). It effectively traces the historical evolution from symptomatic treatments to mechanism-based strategies targeting neurohormonal dysregulation. Central to the discussion is the “Fantastic Four” drug regimen—ARNIs, β-blockers, MRAs, and SGLT2 inhibitors—whose synergistic use has been shown to significantly improve mortality and morbidity. The thesis integrates mechanistic insights with evidence from landmark trials such as PARADIGM-HF and PIONEER-HF, demonstrating both efficacy and safety of ARNI therapy. It also explores the expanding potential of these therapies in HFpEF and pediatric populations. Overall, this work presents a well-structured and evidence-based perspective on modern HF treatment, underscoring the clinical impact of ARNI-based strategies.Tétel Korlátozottan hozzáférhető Pharmacological management of bronchial asthma focusing on biological treatmentYoshikawa, Takahide; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi, Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetBronchial asthma is a chronic inflammatory airway disease characterized by variable symptoms and reversible airflow limitation. In recent years, biologic therapies have emerged as an important treatment option, particularly for patients with severe or therapy-resistant asthma. The aim of this thesis was to review current pharmacological treatment strategies for asthma, with a focus on the clinical role and effectiveness of biologic therapy. The review was based on international clinical guidelines and recent randomized controlled trials published between 2018 and 2025. Biologic agents targeting IgE, IL-5, IL-4 receptor, and TSLP have shown significant reductions in exacerbation rates, oral corticosteroid dependence, and symptom burden in selected patient populations. Treatment response appears to correlate with biomarkers such as blood eosinophil count, IgE levels, and fractional exhaled nitric oxide (FeNO). In conclusion, biologic therapy represents a major advancement in asthma management. Appropriate patient selection and a biomarker-guided approach are key to achieving optimal outcomes.Tétel Korlátozottan hozzáférhető The pharmacological management of inflammatory diseases : Comparing NSAIDs with novel anti-inflammatory agentsHong, Sun Ho; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis reviews the pharmacological management of inflammatory diseases by comparing traditional non-steroidal anti-inflammatory drugs (NSAIDs) with novel targeted anti-inflammatory agents. It outlines key inflammatory pathways and mediators, including cyclo-oxygenase-derived prostaglandins and major cytokine signaling networks. NSAIDs are discussed in terms of mechanical of action, clinical indications, and limitations related to gastrointestinal, renal and cardiovascular adverse effects. The thesis then summarizes newer therapies such as biological targeting TNF-alpha and interleukin pathways, as well as Janus kinase (JAK) inhibitors. Their benefits in disease control and prevention of structural damage are contrasted with safety considerations, monitoring requirements, and cost. Overall, NSAIDs remain first line for acute pain and short term inflammatory symptoms, whereas targeted therapies are preferred for chronic immune mediated diseases requiring sustained disease modification.Tétel Korlátozottan hozzáférhető antidepressant pharmacological approaches to treatment-resistant depressionCho, Habin; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetTreatment-resistant depression (TRD) is a severe form of depression that does not respond to standard antidepressant treatments. This thesis reviews pharmacological strategies for TRD, with emphasis on novel antidepressant and combination therapies. Emerging treatments such as ketamine, esketamine, zuranolone, and psilocybin may improve treatment outcomes in patients with TRD.Tétel Korlátozottan hozzáférhető The Role of Acupuncture and Chinese Herbal Formulas in Managing Sleep Disorders Compared to Western Sleeping PillsCHEN, HSI AN; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetCHM and Acupuncture offer stable, long-term efficacy without the risk of dependence or withdrawal symptoms. TCM modalities are superior for elderly patients and those with chronic insomnia due to fewer adverse events. Combining TCM with Western medicine can enhance therapeutic outcomes and reduce drug dosage.Tétel Korlátozottan hozzáférhető Fantastic four of pharmacological point of viewMuku, Takeda; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi , József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis focuses on the pharmacological treatment of heart failure with reduced ejection fraction (HFrEF). It examines the four main drug classes known as the “Fantastic Four”: RAAS inhibitors, beta-blockers, mineralocorticoid receptor antagonists, and SGLT2 inhibitors. The mechanisms of action and clinical benefits of these therapies are discussed. Evidence from major clinical trials is briefly reviewed. These medications significantly reduce mortality and hospitalization in patients with HFrEF. The study emphasizes the importance of early and combined use of these drugs in clinical practice.Tétel Korlátozottan hozzáférhető Pharmacological Management of Vitiligo: Efficacy of Topical and Systemic TherapiesAbboud, Hala; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetVitiligo is a chronic autoimmune depigmenting disorder with substantial psychosocial burden, driven by genetic susceptibility, oxidative stress, and T‑cell–mediated immune responses centered on the IFN‑γ–CXCL10–CXCR3 axis. This thesis reviews current pharmacological management, evaluating the efficacy and safety of established topical and systemic therapies and the emerging role of Janus kinase (JAK) inhibitors. A systematic literature review of randomized controlled trials, meta‑analyses, and clinical guidelines covers topical corticosteroids, calcineurin inhibitors, phototherapy-based regimens, systemic immunosuppressants, antioxidants, and novel targeted agents. Topical corticosteroids and calcineurin inhibitors remain first‑line for localized disease, while systemic corticosteroids are key for rapidly progressive cases. Among recent advances, JAK inhibitors such as topical ruxolitinib and systemic ritlecitinib show meaningful repigmentation with acceptable safety. Combination strategies, particularly pharmacologic agents plus NB‑UVB, generally achieve higher repigmentation rates than monotherapy. Persistent limitations include variable and site‑dependent responses, adverse‑effect profiles and relapse risk, and restricted access to newer targeted therapies. Overall, the thesis highlights the need for individualized, combination-based strategies and for broader, equitable access to emerging targeted drugs.Tétel Korlátozottan hozzáférhető Pharmacotherapeutic modulation of myocardial reperfusion injuryParadza, Tatenda; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetPharmacotherapeutic modulation of myocardial reperfusion injury aims to limit the additional damage that occurs when blood flow is restored after ischemia, such as in acute myocardial infarction. Reperfusion can trigger oxidative stress, inflammation, calcium overload, and mitochondrial dysfunction. Various drugs targeting these pathways have been investigated, but achieving consistent clinical benefit remains challenging.Tétel Korlátozottan hozzáférhető Complex Treatment of Soft Tissue Neoplastic DiseasesFujiki, Chizuru; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetMy thesis is about soft tissue neoplastic diseases which have significant therapeutic challenges due to their heterogeneity and limited responsiveness to single treatment. This is why complex treatment including surgery, radiotherapy, and systemic pharmacotherapy are required to achieve disease control. From pharmacological perspective, antineoplastic drugs act through diverse mechanisms, including DNA damage, disruption of cell cycle, inhibition of angiogenesis and signaling pathways. However, the efficacy is limited by the drug resistance, cumulative toxicity, and drug-drug interactions. These factors make us necessary to do careful drug selection, sequencing, and monitoring. As a consequence, pharmacology plays a central role in optimizing treatment and improving clinical outcomes in patients with soft tissue neoplastic diseases.Tétel Korlátozottan hozzáférhető New Aspects in The Treatment of Neurodegenerative DiseasesChamaa, Fares; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara; Szentmiklósi, József; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetIn this thesis the we discuss Neurodegenerative diseases, there types and mechanism of action of the most common ones. Focusing on the new aspects in the treatment of Neurodegenerative diseases. Due to the general population getting older, there has been a significant increase in neurodegenerative disease cases which according to the WHO, within 20 years it will become the second most prevalent cause of death. Therefore, researchers are looking for definitive cure for it, since the current treatments are symptomatic only.Tétel Korlátozottan hozzáférhető Comparative effectiveness of Antihistamine and Leukotriene receptor blockers in pediatric allergic rhinitisEtabong , Charlotte Ngum; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri , Attila; Halasi, Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetAllergic rhinitis is one of the most prevalent chronic inflammatory conditions in children and significantly affects overall quality of life. This thesis evaluates the comparative effectiveness and safety of oral antihistamines and leukotriene receptor blockers in the management of pediatric allergic rhinitis. A structured narrative review of randomised controlled trials and meta-analyses, including international guidelines, was conducted. The findings show antihistamines provide superior overall symptom control, particularly for daytime symptoms, while montelukast is more beneficial for nasal congestion and for children coexisting with asthma. Treatment selection should therefore be individualised based on symptom profile, safety considerations and current guidelines.Tétel Korlátozottan hozzáférhető Newer treatment options in epilepsyAdekunle, Isaac; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklosi, Jozsef; Halasi, Dora Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis was an overview into the limitations of the older antiepileptic, emphasizing the need for newer treatment options in patients presenting with refractory epilepsy. It includes neuromodulatory therapies such as the vagus nerve stimulation, deep brain stimulation, the use of gene and molecular therapies and other newer pharmacological treatments such as cannabinoids, cenobamate, everolimus and stripentol.Tétel Korlátozottan hozzáférhető Recent advances in targeted therapy for exocrine pancreatic cancerAl shaka, Asma; Megyeri, Attila; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Dóra Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetExocrine pancreatic cancer, mainly pancreatic ductal adenocarcinoma (PDAC), has a very poor prognosis and is one of the deadliest cancers worldwide because of its aggressive nature. It is often diagnosed at advanced stages, and standard chemotherapy usually has limited effectiveness. While improvements in surgical methods and the use of systemic chemotherapy have led to better outcomes for some patients, overall survival rates remain low. Recently, major advances in molecular and genetic studies have significantly improved our understanding of the biological processes behind PDAC progression. This progress has also helped in developing targeted therapies aimed at oncogenic drivers and parts of the tumor microenvironment. This paper will explore recent developments in targeted therapies for pancreatic cancer. It focuses on molecular targets such as KRAS and its signaling pathways, DNA damage repair mechanisms including BRCA1/2 mutations, and changes in cell cycle regulation and growth factor signaling. It will also examine results from relevant clinical trials. Furthermore, it will consider the importance of biomarker-driven patient selection and personalized treatment methods.Tétel Korlátozottan hozzáférhető Pharmacotherapy of Trigeminal NeuralgiaPerez Novoa, Gabriella; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis medical thesis provides a comprehensive analysis of Trigeminal Neuralgia, a debilitating condition characterized by intense, paroxysmal facial pain. The author explores the neuroanatomical foundations of the trigeminal nerve and details how current classification systems differentiate between classical, secondary, and idiopathic subtypes. A significant portion of the text evaluates pharmacological strategies, identifying This medical thesis offers a detailed analysis of Trigeminal Neuralgia, a disabling condition marked by intense, sudden facial pain. The author discusses the neuroanatomy of the trigeminal nerve and explains how current classification systems distinguish between classical, secondary, and idiopathic subtypes. A large part of the study evaluates drug treatments, highlighting carbamazepine and oxcarbazepine as the main first-line options while exploring new molecular therapies and anticonvulsants. Besides medication, the paper reviews surgical procedures such as microvascular decompression and various percutaneous methods for patients with treatment-resistant symptoms. Ultimately, the work promotes a multidisciplinary approach to treatment, stressing the importance of personalized care to enhance the long-term quality of life for those affected by this chronic nerve disorder.carbamazepine and oxcarbazepine as the primary first-line treatments while examining emerging molecular therapies and anticonvulsants. Beyond medication, the document assesses surgical interventions like microvascular decompression and various percutaneous procedures for patients with treatment-resistant symptoms. Ultimately, the work advocates for a multidisciplinary approach to management, emphasizing the need for personalized care to improve the long-term quality of life for those suffering from this chronic neuropathic disorder.