After conducting a thorough research on antibiotics in dentistry, it has been found that dentists play a very vital role in prescribing antibiotics and in its resistance. Diagnosis should be made to find the causative organism. If it is not clear, appropriate test should be carried out to prove it. Once that is done, the correct drug with accurate spectrum of antibiotics should be prescribed with the correct regimen. It is very important for all practitioners especially dentists to diagnose the patient accurately and prescribe antibiotics with an apt regimen only if necessary in order to prevent the antibiotic prevalence and the side-effects caused by the antibiotic abuse.This way, the anti-microbial prescribing can be minimised globally which will eventually lead to the decrease of antibiotic resistance and the sideeffects caused by its abuse.