This research provides an overview of the actual panorama of the entrepreneurship ecosystem in Mexico, the objective of this study is to examine the factors of the entrepreneurship ecosystem in Mexico mainly the Higher Education Institutions (HEIs) entrepreneurship ecosystem in the Northeast of Mexico with a focus on the entrepreneurship programs and their impact on the master’s graduate students. Was used the Delphi method with a panel of experts to 21 individuals that were belonging to the national entrepreneurial program (PRODEM) and from the side of the student’s point of view was applied successfully a Likert scale survey to 120 graduated master individuals in businesses/administrative areas and analyzing the results with the (PLS) Partial Least Squares using the structural equation model, which is useful for this type of social studies, were the point is to find a correlation between two or more complex topics. The conclusion of this dissertation contributes to a better comprehension of the factors that influence graduate students' decisions to pursue business economic degrees, as a result was proposed a framework that can be used as a tool for policymakers, educators, and stakeholders to improve the HEIs entrepreneurial ecosystem of Mexico's Northeast region.