Pharmacological treatment of Parkinson’s disease

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorVygovska, Mariia
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentDrimba, László
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.opponentdeptKenézy Kórház Aneszteziológiai és Intenziv Therápiás Osztályhu_HU
dc.date.accessioned2017-07-14T08:11:49Z
dc.date.available2017-07-14T08:11:49Z
dc.date.created2016-06
dc.description.abstractThe main attention in the management of Parkinson's disease is directed on the treatment of motor and non- motor features of the disorder, as well as on the improvement of patient’s overall quality of life. The main strategies for pharmacological therapy include increasing dopamine activity in the brain, decreasing muscarinic cholinergic activity, or both. L-DOPA, used in combination with carbidopa, is the most effective pharmacological agent for PD and remains the gold standard of the primary treatment for symptomatic patients. Dopamine agonists are useful for early PD, highly effective as an adjunctive therapy to L-DOPA in the advanced disease, and furthermore causing a lower tendency for individuals to develop motor complications. MAO-B inhibitors may be used for the treatment of patients with early PD with mild-to-moderate motor features before initiating treatment with LC or DAs, and as an adjuvant for patients with motor fluctuations. As an initial management of PD, MAO-B inhibitors showed similar efficacy as DAs in the treatment of motor symptoms. Numerous non-pharmacological strategies that are used for PD treatment are exercise programs and occupational, physical, and speech therapy, which may provide a clinical benefit when used as an adjunctive treatment.hu_HU
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent40hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/242579
dc.language.isoenhu_HU
dc.subjectpharmacologicalhu_HU
dc.subjecttreatmenthu_HU
dc.subjectmanagementhu_HU
dc.subjectParkinson’shu_HU
dc.subjectParkinsonhu_HU
dc.subjectdiseasehu_HU
dc.subjectetiologyhu_HU
dc.subjectpathogenesishu_HU
dc.subjectclinical presentationhu_HU
dc.subjectsymptomshu_HU
dc.subjectlevodopahu_HU
dc.subjectDAhu_HU
dc.subjectdopamine agonistshu_HU
dc.subjectMAO-B inhibitorshu_HU
dc.subjectanticholinergicshu_HU
dc.subjectamantadinehu_HU
dc.subjectCOMT inhibitorshu_HU
dc.subjectcentrally acting muscle relaxantshu_HU
dc.subjectneuroprotectivehu_HU
dc.subjectnon-pharmacologicalhu_HU
dc.subjectsurgicalhu_HU
dc.subjectcomorbidhu_HU
dc.subjectpalliativehu_HU
dc.subjectL-DOPAhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titlePharmacological treatment of Parkinson’s diseasehu_HU
dc.title.translatedPharmacological treatment of Parkinson’s diseasehu_HU
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