Investigation of potential immune-modulatory effects of the activation of hypothalamic hormone receptors in cancer cells

A tétel rövid nézete
dc.contributor.advisorDobos, Nikoletta
dc.contributor.advisorHalmos, Gábor
dc.contributor.advisordeptDebreceni Egyetem::Gyógyszerésztudományi Kar::Biofarmácia Tanszékhu_HU
dc.contributor.authorMirani, Sara
dc.contributor.departmentDE--Gyógyszerésztudományi Karhu_HU
dc.contributor.opponentFenyvesi, Ferenc
dc.contributor.opponentVecsernyés, Miklós
dc.contributor.opponentdeptDebreceni Egyetem::Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszékhu_HU
dc.date.accessioned2017-05-05T06:44:10Z
dc.date.available2017-05-05T06:44:10Z
dc.date.created2017-03-17
dc.description.abstractSeveral mechanisms have been demonstrated to play a role in the development, survival, and promotion of metastases of various tumors. One of these key mechanisms is the inhibition of the immune system. In the current research study, we are investigating the effect of receptor agonists and antagonists on IDO RNA and protein expression in an LHRH receptor expressing human cervical cancer cell line (HeLa cells), it has been shown the IDO overexpression after treatment with LHRH analogs in different time intervals which helps the tumor to suppress the immune system.hu_HU
dc.description.correctorVÁ
dc.description.coursegyógyszerészhu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent38hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/239454
dc.language.isoenhu_HU
dc.subjectimmunosuppressivehu_HU
dc.subjectcancer immunotherapy
dc.subjectIDO expression
dc.subjectLHRH
dc.subjectLHRH receptor
dc.subjectcancer
dc.subjectHeLa cells
dc.subjectGnRH
dc.subjectGnRH receptor
dc.subjecttryptophan catabolism
dc.subjectkynurenine pathway
dc.subjectLHRH analogs
dc.subjecttryptorelin
dc.subjectcetrorelix
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleInvestigation of potential immune-modulatory effects of the activation of hypothalamic hormone receptors in cancer cellshu_HU
dc.title.translatedA hypothalamus hormon receptorok aktiválódásának potenciális immunmoduláló hatásainak vizsgálata rákos sejtekbenhu_HU
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Theses (Faculty of Pharmacy)