Role of lncRNA expression in glioblastoma

A tétel rövid nézete
dc.contributor.advisorBuglyó, Gergely
dc.contributor.authorErdenesanaa, Angiraa
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biológiai és Ökológiai Intézethu_HU
dc.date.accessioned2021-04-29T21:01:08Z
dc.date.available2021-04-29T21:01:08Z
dc.date.created2021-04-29
dc.description.abstractGlioblastoma (GBM) is amongst the most frequently identified malignant brain tumors, it has a high mortality rate and a poor prognosis. The overall survival rate remains poor despite the multimodal therapies including acute resection, radiotherapy and chemotherapy, highlighting the urgent need for more effective targeted therapy. It is strongly implied that deregulated expression of noncoding RNAs in GBM is linked to cancer development, recurrence and proliferation. Non-coding RNAs are RNA species that do not encode proteins, suggested to form complex regulatory networks linked to a variety of biological processes. Disruption of the main components of these networks causes an interruption in cell function, leading to various human diseases. Long noncoding RNAs (lncRNAs) have been shown to be abnormally present in a number of cancers, and their expression has been related to tumor pathology, so they could be useful diagnostic and prognostic biomarkers. Furthermore, lncRNAs are implicated in carcinogenesis as oncogenes or as tumor suppressors. The aim of this thesis research is to explore lncRNA deregulations in glioblastoma, by analysing long noncoding RNA expression in healthy and cancerous samples of brain tissues.hu_HU
dc.description.courseBiochemical engineeringhu_HU
dc.description.degreeBSc/BAhu_HU
dc.format.extent32hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/307856
dc.language.isoenhu_HU
dc.subjectglioblastomahu_HU
dc.subjectlncRNAhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudomány::Onkológiahu_HU
dc.subject.dspaceDEENK Témalista::Biológiai tudományokhu_HU
dc.titleRole of lncRNA expression in glioblastomahu_HU
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Gyűjtemények
Theses (Faculty of Science and Technology)