Cytotoxic effects of synthetic C. sativa derivatives on melanoma cells and other, non-malignant cell lines

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dc.contributor.advisorSzabó, Erzsébet
dc.contributor.authorMondal, Amartya Baran
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biotechnológiai Intézet
dc.date.accessioned2025-06-17T12:47:24Z
dc.date.available2025-06-17T12:47:24Z
dc.date.created2025-05-02
dc.description.abstractThis study investigated the cytotoxic effects of the synthetic cannabigerol derivative, LE-127/2, on melanoma cells and its influence on non-malignant cell lines. The findings indicated that LE-127/2 significantly suppressed melanoma cell proliferation and colony formation in a dose-dependent fashion while promoting autophagy-mediated cell death. Its reduced cytotoxicity towards non-malignant cells, in comparison to the parent compound cannabigerol (CBG), underscores its promise as a safer therapeutic alternative. Although LE-127/2 demonstrated potential anti-melanoma efficacy, the elevated IC50 values in comparison to CBG underscore the necessity for additional optimization and validation. The results endorse the advancement of LE-127/2 as a new candidate for melanoma treatment, with forthcoming research aimed at in vivo efficacy and pharmacokinetic analysis to comprehensively ascertain its therapeutic potential.
dc.description.courseBiochemical Engineering
dc.description.degreeBSc/BA
dc.format.extent42
dc.identifier.urihttps://hdl.handle.net/2437/393066
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectCannabinoids
dc.subjectCannabigerol (CBG)
dc.subjectCannabidiol (CBD)
dc.subjectAutophagy and apoptosis
dc.subjectCytotoxicity
dc.subjectCell proliferation
dc.subjectLE-127/2
dc.subjectMelanoma
dc.subject.dspaceBiology
dc.titleCytotoxic effects of synthetic C. sativa derivatives on melanoma cells and other, non-malignant cell lines
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