Synthesis and physicochemical characterization of a pH- responsive Mn(II)-based Magnetic Resonance Imaging (MRI) contrast agent candidate derived from pyclen

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dc.contributor.advisorTircsó, Gyula
dc.contributor.authorZahari, Fairodzliana binti
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Kémiai Intézet
dc.date.accessioned2023-05-05T06:39:23Z
dc.date.available2023-05-05T06:39:23Z
dc.date.created2023-05-04
dc.description.abstractThis research focuses on the synthesis of a ligand that can complex with Mn(II) and acts as a pH-sensitive probe in MR imaging studies. The ligand was synthesized by modifying pyclen and was found to form thermodynamically and kinetically stable complexes with essential metal ions. The complex showed pH sensitivity through relaxometric measurement. The dissociation kinetics parameters of the complex were also found to be improved compared to related Mn(II) complexes. The results suggest that this ligand has potential practical applications as a pH-sensitive probe in MR imaging.
dc.description.correctorLB
dc.description.courseSynthetic Chemistry
dc.description.degreeMSc/MA
dc.format.extent45
dc.identifier.urihttps://hdl.handle.net/2437/351900
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectPyclen derivatives
dc.subjectpH responsive
dc.subjectMagnetic Resonance Imagine Contrast Agent
dc.subject.dspaceDEENK Témalista::Kémia::Fizikai kémia
dc.subject.dspaceDEENK Témalista::Kémia
dc.subject.dspaceDEENK Témalista::Kémia::Szerves kémia
dc.titleSynthesis and physicochemical characterization of a pH- responsive Mn(II)-based Magnetic Resonance Imaging (MRI) contrast agent candidate derived from pyclen
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