This research studies the isotopic ratio 176Hf/177Hf, 87Sr/86Sr, and 143Nd/144Nd analysis of hafnium (Hf), strontium (Sr), and neodymium (Nd) in Geological Reference material (GRMs), namely AGV-2, BCR-2 AND GSP-2, using ammonium bifluoride (ABF) as a dissolution reagent for rock sample decomposition and Multi-Collector Inductively Coupled Plasma Mass Spectrometer (MC-ICP-MS) for measuring isotope ratios. The study evaluated the performance of ABF for the dissolution of geological reference materials (GRMs) AGV-2, BCR-2, and GSP-2, which represent igneous rocks ranging from mafic to felsic compositions.