Citric Acid Production by Genetically Modified Aspergillus Niger

dc.contributor.advisorMárton, Alexandra
dc.contributor.authorVardanean, Arutiun
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biotechnológiai Intézet
dc.date.accessioned2026-01-08T13:00:05Z
dc.date.available2026-01-08T13:00:05Z
dc.date.created2025
dc.description.abstractCitric acid is produced mostly through fermentation by Aspergillus niger fungi. Alongside some other fungi, plants, algae, animals, and bacteria, A. niger can switch the electron transport chain from the classical Cytochrome Pathway to the Alternative Pathway, using the Alternative Oxidase (AOX) enzyme. Besides AOX, encoded by the aoxA gene, which is ubiquitous, some Aspergillaceae strains have developed a paralogous aoxB gene. In this study, a genetically modified A. niger strain without the aoxA gene was compared to a non-GMO wild-type strain in terms of citric acid productivity, biomass productivity, and viability. Also, the study answers whether the GMO strain uses the AOX B enzyme, encoded by the aoxB, equally to the classical AOX enzyme in the case of its absence.
dc.description.courseBiochemical Engineering
dc.description.degreeBSc/BA
dc.format.extent31
dc.identifier.urihttps://hdl.handle.net/2437/401823
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectCitric acid
dc.subjectAspergillus niger
dc.subjectAlternative Oxidase
dc.subjectAOX
dc.subjectaoxA
dc.subjectFermentation
dc.subject.dspaceBiology::Biotechnology
dc.titleCitric Acid Production by Genetically Modified Aspergillus Niger
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