Synthesis of Dithioacetal-β,β-Digalactosides as Potential Lectin Ligands

A tétel rövid nézete
dc.contributor.advisorAnikó , Borbás
dc.contributor.advisorGhanem Kattoub, Rasha
dc.contributor.authorAziz, Nazish
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Kémiai Intézet
dc.date.accessioned2026-01-08T10:20:01Z
dc.date.available2026-01-08T10:20:01Z
dc.date.created2025-11-21
dc.description.abstractThis work describes the synthesis of novel dithioacetal-digalactoside derivatives as potential inhibitors of Pseudomonas aeruginosa LecA lectin. Pseudomonas aeruginosa is a WHO-classified priority pathogen that uses lectins for biofilm formation, contributing to antibiotic resistance. A library of bivalent and tetravalent thiogalactoside compounds was successfully synthesized through a two-step process involving thioacetalization with aromatic aldehydes followed by Zemplén deacetylation. The synthesized compounds exhibited good to excellent yields and were fully characterized by NMR spectroscopy and mass spectrometry. These sulfur-containing glycomimetics offer enhanced stability compared to natural carbohydrates and represent promising candidates for anti-biofilm therapeutic strategies against antibiotic-resistant bacterial infections.
dc.description.courseChemistry
dc.description.degreeBSc/BA
dc.format.extent34
dc.identifier.urihttps://hdl.handle.net/2437/401804
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectCarbohydrates, Lectins, Pseudomonas aeruginosa, Thioglycosides, Dithioacetals, Glycomimetics, D-galactosyl derivatives, Dimethyl acetal, Zemplén deacetylation
dc.subject.dspaceDEENK Témalista::Kémiahu_HU
dc.titleSynthesis of Dithioacetal-β,β-Digalactosides as Potential Lectin Ligands
Fájlok
Eredeti köteg (ORIGINAL bundle)
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
BSc Thesis
Méret:
2.12 MB
Formátum:
Adobe Portable Document Format
Leírás:
Nazish Aziz BSc Thesis - 19.11.2025 RGK, BA.pdf
Megjelenítés
Engedélyek köteg
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
license.txt
Méret:
1.94 KB
Formátum:
Item-specific license agreed upon to submission
Leírás:
Letöltés
Gyűjtemények
Theses (Faculty of Science and Technology)