This paper presents the improvement and usage of a comprehensive physiological monitoring system aimed at giving users with real-time access to their health measurements. Joining physiological sensors for data collection, the system encourages data acquisition by means of a custom-designed PCB connected to a Raspberry Pi and Arduino Uno. Serial communication, facilitated by PySerial, ensures efficient data transfer, while a keypad on the PCB enables precise sensor selection to prevent data collision. Python scripts on the Raspberry Pi process incoming sensor data, generating real-time graphs in a GUI developed with Geany and Tkinter. Users can navigate the GUI to select sensors, view data, and access historical measurements, enhancing their monitoring experience. The integration of sensor data acquisition, PySerial communication, and GUI development enables comprehensive real-time monitoring and user interaction. Furthermore, recorded data is stored in SQLite database for further analysis, advance examination, enabling users to effectively engage in their health management. Through user-centric friendly design and technical development, this system bridges the gap between complex healthcare technologies and user accessibility, empowering engaging people to take control of their wellbeing.