Synthesis of new platinum-group metal half-sandwich complexes of N-(β-D-glucopyranosylcarbonyl)-N'-acylhydrazines as potential anticancer agents

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dc.contributor.advisorJuhászné Tóth, Éva
dc.contributor.authorBabić, Minja
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Kémiai Intézet
dc.date.accessioned2026-01-07T12:39:40Z
dc.date.available2026-01-07T12:39:40Z
dc.date.created2025-11-28
dc.description.abstractThis thesis focuses on the synthesis of new half-sandwich platinum-group metal complexes containing carbohydrate-derived acylhydrazine ligands. In connection with the research activity of the Chemical Glycobiology Research Group, three sugar-based ligand families were coordinated to Ru(II), Os(II), and Rh(III) metal centers using established complexation methods. Five new complexes were successfully prepared and purified, and their structures were confirmed by NMR spectroscopy. Two additional complexes were formed but could only be obtained as mixtures. This work expands the library of carbohydrate-metal conjugates and contributes to structure-activity relationship studies within medicinal inorganic chemistry. These complexes represent promising candidates for further biological evaluation, particularly regarding anticancer potential.
dc.description.courseBiochemical Engineering
dc.description.degreeBSc/BA
dc.format.extent35
dc.identifier.urihttps://hdl.handle.net/2437/401768
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectHalf-sandwich metal complexes
dc.subjectPlatinum-group metals
dc.subjectAcylhydrazines
dc.subjectMedicinal inorganic chemistry
dc.subjectSugar-based coordination compounds
dc.subjectOrganometallic chemistry
dc.subjectBioinorganic anticancer agents
dc.subject.dspaceChemistry
dc.titleSynthesis of new platinum-group metal half-sandwich complexes of N-(β-D-glucopyranosylcarbonyl)-N'-acylhydrazines as potential anticancer agents
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