Synthesis and Characterization of a Liver-Specific MRI Probe based on Manganese (II) formed with 3,9-PC2A

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dc.contributor.advisorTircsó, Gyula
dc.contributor.authorAchacoso, Alexis
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Kémiai Intézet
dc.date.accessioned2023-05-05T06:40:26Z
dc.date.available2023-05-05T06:40:26Z
dc.date.created2023-05-04
dc.description.abstractDue to their serious health issues, there is growing interest in developing safer alternatives to gadolinium-based MRI contrast agents (GBCA). Manganese(II) is considered a potential alternative metal due to its essential nature as a micronutrient, and ligands that can chelate manganese have been extensively studied. This research has developed a novel contrast agent (CA) candidate by complexing Mn(II) to form [Mn(3,9-PC2A-6-EOB)], which combines the outstanding properties of 3,9-PC2A and the liver specificity of the EOB moiety. The synthesized Mn(II)-based MRI CA candidate [Mn(3,9-PC2A-6-EOB)] has shown high thermodynamic stability and is highly inert towards Zn(II) transmetallation, indicating its superior stability and inertness compared to clinically approved GBCA, gadobenate. This novel CA candidate has excellent potential for future in-vivo studies and ultimately acts as a safer and more effective liver-specific MRI CA.
dc.description.correctorLB
dc.description.courseSynthetic Chemistry
dc.description.degreeMSc/MA
dc.format.extent45
dc.identifier.urihttps://hdl.handle.net/2437/351901
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectmacrocycle
dc.subjectcontrast agent
dc.subjectmagnetic resonance imaging
dc.subjectsmart contrast agent
dc.subject.dspaceDEENK Témalista::Kémia::Fizikai kémia
dc.subject.dspaceDEENK Témalista::Kémia::Szerves kémia
dc.titleSynthesis and Characterization of a Liver-Specific MRI Probe based on Manganese (II) formed with 3,9-PC2A
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