Synthesis of condensed heterocycles with potential antiproliferative activity

A tétel rövid nézete
dc.contributor.advisorKurtán, Tibor
dc.contributor.authorMahama, Mahamadu Tiah
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Kémiai Intézethu_HU
dc.date.accessioned2019-05-10T06:03:48Z
dc.date.available2019-05-10T06:03:48Z
dc.date.created2019-05-09
dc.description.abstractThe goal of this dissertation was to carry out synthesis of condensed heterocyclic analogues of a lead compound via domino Knoevenagel-hetero-Diels-Alder reaction, for evaluation of their antiproliferative activities. Starting from 4-methoxyphenol, starting material of the domino cyclization was prepared in four steps. Beta di-carbonyl reagents were reacted with these derivatives to produce ten condensed chiral O-heterocycles for pharmacological studies. The preliminary antiproliferative test of compound 87a on A2780 (ovarian carcinoma) and WM35 (melanoma) showed improvement relative to the original compound.hu_HU
dc.description.correctorgj
dc.description.courseSynthetic Chemistryhu_HU
dc.description.degreeMSc/MAhu_HU
dc.format.extent44hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/267263
dc.language.isoenhu_HU
dc.subjectCondensed heterocycleshu_HU
dc.subjectAntiproliferativehu_HU
dc.subjectDiels-Alder reactionhu_HU
dc.subjectHetero Diels-Alderhu_HU
dc.subjectKnoevenagel condensationhu_HU
dc.subjectDomino reactionhu_HU
dc.subject.dspaceDEENK Témalista::Kémiahu_HU
dc.titleSynthesis of condensed heterocycles with potential antiproliferative activityhu_HU
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Theses (Faculty of Science and Technology)