Synthesis and study of zwitterionic, Gd (III)-chelating macromolecules based on poly (glycidyl methacrylate)

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dc.contributor.advisorNovák, Levente
dc.contributor.authorMakumbi, Emily Kawuki
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Kémiai Intézet
dc.date.accessioned2023-05-17T06:12:29Z
dc.date.available2023-05-17T06:12:29Z
dc.date.created2023-05-17
dc.description.abstractThe purpose of this study is to complex Gd(III) ions using functionalized poly(glycidyl methacrylate), which was created. It was unsuccessful to functionalize the polymer after its initial synthesis using picolinic derivatives. We revised our approach and decided to functionalize the monomer (glycidyl methacrylate) first before polymerizing it. Amino acids were substituted for the original chelating agent. This turned out to be quite effective, and evidence from DOSY NMR, SEC chromatography, and proton affinity spectrums could support functionalization and polymerization. The relaxivitives were 4 times better when comparing complexation characterization to the Gd(III) aqua complex. This study adds to current research into better contrast agents with higher relaxivities that would allow for lower dosages of these agents without compromising the accuracy of the images produced by the diagnostic equipment.
dc.description.correctorLB
dc.description.courseChemistry
dc.description.degreeMSc/MA
dc.format.extent39
dc.identifier.urihttps://hdl.handle.net/2437/353634
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectGMA: Glycidyl methacrylate (oxiran-2-ylmethyl 2-methylprop-2-enoate, 2,3-epoxypropyl methacrylate)
dc.subjectpAsp-GMA: Poly-aspartic-glycidyl-methacrylate
dc.subjectpolyGMA/pGMA: Poly(glycidyl methacrylate)
dc.subjectpPro-GMA: Poly-proline-glycidyl-methacrylate
dc.subjectpHis-GMA: Poly-histidine-glycidyl-methacrylate
dc.subject.dspaceDEENK Témalista::Kémia
dc.titleSynthesis and study of zwitterionic, Gd (III)-chelating macromolecules based on poly (glycidyl methacrylate)
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