Intracellular ligand binding of the epidermal growth factor to its receptor

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dc.contributor.advisorVolkó, Julianna
dc.contributor.advisorVámosi, György
dc.contributor.authorJeppesen, Chinzorig
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biotechnológiai Intézethu_HU
dc.date.accessioned2021-11-22T07:55:23Z
dc.date.available2021-11-22T07:55:23Z
dc.date.created2021
dc.description.abstractHuman epidermal growth factor receptor (EGFR) plays an important role in homeostatic proliferation of epithelial cells. Mutations and gene amplification may result in overexpression of EGFR, and consecutively increased cell growth and proliferation. Hence, EGFR is associated with various types of cancer. Epidermal growth factor (EGF) and EGF-like ligands bind to EGFR inducing receptor oligomerization and activation. The mechanism of activation in the cell membrane is well understood, and monoclonal antibody therapies targeting membrane-localized EGFR to block binding of EGF are widely used. Based on our fluorescence anisotropy results (measured on transfected cell line), we suggest that cells expressing both EGFR and EGF, the receptor activation may occur intracellularly in the Golgi apparatus. In such case, the membrane-bound EGFR-targeting drugs may not be sufficient in cancer therapy, and drugs targeting intracellularly activated receptors may be required.hu_HU
dc.description.correctorhbk
dc.description.courseBiochemical Engineeringhu_HU
dc.description.degreeBSc/BAhu_HU
dc.format.extent50hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/325215
dc.language.isoenhu_HU
dc.subjectintracrine signallinghu_HU
dc.subjectreceptor activationhu_HU
dc.subjectfluorescence anisotropyhu_HU
dc.subject.dspaceDEENK Témalista::Biológiai tudományok::Biofizikahu_HU
dc.subject.dspaceDEENK Témalista::Biológiai tudományok::Molekuláris biológiahu_HU
dc.titleIntracellular ligand binding of the epidermal growth factor to its receptorhu_HU
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