Investigation of 1,3-dipolar cycloaddtion reactions of C-glycopyranosyl nitrile oxides with endo-glycals

Abstract

In this study, the investigation focused on optimizing reaction conditions for the synthesis of annealed isoxazolines using various carbohydrate substrates. Through systematic experimentation, it was found that the yield of the desired products varied significantly depending on factors such as reactant stoichiometry and choice of oxidizing agent. While some conditions yielded moderate to high yields of furoxane, the synthesis of annelated isoxazolines proved to be more challenging, with lower overall yields observed. These findings highlight the importance of fine-tuning reaction parameters to achieve optimal results in carbohydrate-based synthesis, paving the way for further exploration in the field of organic chemistry.