Allogeneic reactions of pre-activated CAR T cells on target-negative cancer cells

A tétel rövid nézete
dc.contributor.advisorNagy, Lőrinc
dc.contributor.authorLi, Artyom
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biotechnológiai Intézet
dc.date.accessioned2024-12-17T08:29:02Z
dc.date.available2024-12-17T08:29:02Z
dc.date.created2024
dc.description.abstractT cells were isolated from 2 donor's PBMCs and transduced with HER2-CAR construct. The study evaluated the cytotoxic activity of HER2-CAR T cells against three cell lines: HER2-negative MDA cells and HER2-positive MDA-HER2 and MDA-HER2-231 cells. The results demonstrated significant cytotoxicity against MDA-HER2 cells, confirming the specificity of HER2-CAR T cells, while no cytotoxic effects were observed for HER2-negative MDA cells and MDA-HER2-231 cells, which had low expression of HER2 antigen. It implies that HER2-CAR T cells are unlikely to target healthy tissues with low expression of HER2. The same pattern was observed in the case of pre-activated T cells, and regardless of IL-2 and the donor of T cells.
dc.description.courseBiochemical Engineering
dc.description.degreeBSc/BA
dc.format.extent45
dc.identifier.urihttps://hdl.handle.net/2437/383192
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectCAR T cells
dc.subjectImmunotherapy
dc.subjectCancer
dc.subjectHER2
dc.subject.dspaceBiology::Immunology
dc.titleAllogeneic reactions of pre-activated CAR T cells on target-negative cancer cells
Fájlok
Eredeti köteg (ORIGINAL bundle)
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
Final.pdf
Méret:
2.49 MB
Formátum:
Adobe Portable Document Format
Leírás:
Megjelenítés
Engedélyek köteg
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
license.txt
Méret:
1.94 KB
Formátum:
Item-specific license agreed upon to submission
Leírás:
Letöltés
Gyűjtemények
Theses (Faculty of Science and Technology)