Design of open-chained ligand with picolinate arm for the complexation of metal ions

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dc.contributor.advisorCsupász, Tibor
dc.contributor.advisorTircsó, Gyula
dc.contributor.authorMudlovo, Fignes
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Kémiai Intézet
dc.date.accessioned2023-12-15T13:19:29Z
dc.date.available2023-12-15T13:19:29Z
dc.date.created2023-11-12
dc.description.abstractThe synthesis of the Oxytaampa ligand, essential for diagnostics, encountered challenges in incorporating a single picolinate pendant arm. Alkylation with methyl 6-formylpyridine-2-carboxylate yielded a modest 12% despite optimization attempts. The second route, using methyl-6-(chloromethyl) picolinate, formed disubstituted products, requiring adjustments for a small yield. Protective measures with Boc2O yielded a low 24.5%, retaining both compounds. The successful approach involved alkylation of a Boc-protected diamine with methyl-6-(bromomethyl)-picolinate, overcoming unexpected disubstituted product formation. This synthesis underscores intricacies in ligand design, emphasizing the need for meticulous optimization for potential diagnostic applications. Future work involves characterizing ligand and metal complexes if produced on a larger scale.
dc.description.courseChemical Engineering
dc.description.degreeBSc/BA
dc.format.extent23
dc.identifier.urihttps://hdl.handle.net/2437/363461
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectContrast agents
dc.subjectMedical Imaging
dc.subjectLigand development
dc.subject.dspaceDEENK Témalista::Kémia
dc.subject.dspaceDEENK Témalista::Orvostudomány
dc.titleDesign of open-chained ligand with picolinate arm for the complexation of metal ions
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