The Effect of Manganese-Phosphate Interaction on the Fermentation Process of Aspergillus terreus.

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dc.contributor.advisorBíró, Vivien
dc.contributor.authorAffor , Lisvin Edinam Konings
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biotechnológiai Intézet
dc.date.accessioned2026-01-08T12:48:17Z
dc.date.available2026-01-08T12:48:17Z
dc.date.created2025-11-27
dc.description.abstractItaconic acid (IA) is a sustainable platform chemical with growing industrial relevance, produced mainly by Aspergillus terreus under controlled nutrient conditions. This study evaluates the effects of manganese (Mn²⁺) and phosphate (PO₄³⁻) on IA production from glucose in submerged fermentation. Under trace Mn²⁺ conditions, IA reached 66.52 g/L at 192 h with an 84.76% molar yield, indicating highly efficient carbon conversion. In contrast, excess Mn²⁺ (30–200 μg/L) reduced IA titers to 50 g/L and promoted increased biomass formation and dispersed hyphal morphology. Phosphate supplementation alone also decreased IA yield by shifting metabolism toward biomass, while combined Mn²⁺ PO₄³⁻ treatment caused an almost complete loss of IA production with dry cell weight reaching 40 g/L. These results demonstrate that only under trace Mn²⁺, controlled phosphate levels, and proper fungal morphology can IA production reach its maximum potential, providing valuable guidance for industrial fermentation optimization.
dc.description.courseBiochemical engineering
dc.description.degreeBSc/BA
dc.format.extent38
dc.identifier.urihttps://hdl.handle.net/2437/401816
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectItaconic acid
dc.subjectAspergillus terreus
dc.subjectManganese phosphate
dc.subjectMicrobial fermentation
dc.subject.dspaceBiology::Biotechnology
dc.titleThe Effect of Manganese-Phosphate Interaction on the Fermentation Process of Aspergillus terreus.
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