Szerző szerinti böngészés "Abdelmonem Hassan, Mohamed Khaled Mohamed"

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    Adhd medications: Past, present, the future.
    Abdelmonem Hassan, Mohamed Khaled Mohamed; Pórszász , Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dóra; Megyeri, Attila; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
    This thesis discusses a common, multifactorial disorder called Attention Deficit Hyperactivity Disorder (ADHD), a neurodevelopmental disorder characterized by persistent patterns of inattention, hyperactivity, and impulsivity. It reviews the evolution of knowledge about ADHD, from explanations related to behavioral disorders to the modern view of it as a brain disorder with strong genetic roots. The article also discusses its association with polygenic risk factors, along with environmental factors that interact to disrupt the regulation of catecholamine systems (dopamine and norepinephrine). Furthermore, it examines the relationship between ADHD and differences in prefrontal and default mode brain networks, which are responsible for executive functions and attention. Diagnosis of ADHD is primarily based on clinical and behavioral assessments, but it is also influenced by self-assessment, developmental variability, and sociodemographic biases, highlighting the need for objective diagnostic biomarkers. Current treatments (particularly stimulants and non-stimulants) are relatively effective in alleviating core symptoms by increasing catecholamine signaling, leading to positive functional effects. However, patient responses to different treatments vary considerably. These variations depend primarily on pharmacokinetics, pharmacogenomics, patient age and health status, and common comorbidities.