Szerző szerinti böngészés "Boustanchi, Ali"
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Tétel Korlátozottan hozzáférhető Comparative test of different antimicrobial preservatives for external pharmaceutical formulationsBoustanchi, Ali; Nemes, Dániel; DE--Gyógyszerésztudományi KarThis study explores the efficacy of antimicrobial preservatives in topical gels, following European Pharmacopoeia guidelines and Hungarian national formulary standards. Results indicate that benzoic and sorbic acid salts exhibit significant antimicrobial activity, making them promising alternatives to parabens. However, zinc gluconate and ethanolic solutions of methyl paraben showed limited efficacy. Surprisingly, the choice of gelling agent did not significantly affect the effectiveness of the tested materials. Overall, the study contributes to enhancing the safety and efficacy of external pharmaceutical formulations by addressing concerns about preservative toxicity and ensuring microbial stability throughout product shelf life.Tétel Korlátozottan hozzáférhető Comparative test of different antimicrobial preservatives for external pharmaceutical formulationsBoustanchi, Ali; Nemes, Daniel; DE--Gyógyszerésztudományi KarThis thesis delves into the crucial role of antimicrobial preservatives in external pharmaceutical formulations, with a specific focus on their efficacy in topical gels. Through adherence to European Pharmacopoeia guidelines and referencing the Hungarian national formulary, Formulae Normales VIII, various preservatives were rigorously evaluated. Findings reveal that benzoic and sorbic acid salts exhibit notable antimicrobial activity, suggesting their viability over traditional options like methyl paraben. Importantly, this study underscores the significance of selecting appropriate preservatives regardless of the gelling agent, aiming to enhance both safety and efficacy while addressing concerns regarding preservative toxicity and ensuring microbial stability throughout product shelf life.