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Tétel Korlátozottan hozzáférhető Copper toxicity in ‘’Armagnac’’, effects on germination, and enzymatic activitiesFrangu, Rrezon; Máthéné Szigeti, Zsuzsa; DE--Természettudományi és Technológiai Kar--Biológiai és Ökológiai IntézetCopper toxicity effect on the germination process and growth parameters of Armagnac hybrid of corn. On Cu-treated samples, germination was slowed and the mass & length of coleoptiles and roots reduced significantly. Copper toxicity has effected also enzymatic activities of ''Armagnac'', Cu in the seed induced abiotic stress, which resulted in the formation of reactive oxygen species (ROS) and oxidative stress, each of which had a distinct influence on the interactions.Tétel Korlátozottan hozzáférhető The role of HCN2 in macrophage cytokine releaseFrangu, Rrezon; Uray, Karen Lee; Általános Orvostudományi Kar::Orvosi Vegytani Intézet; DE--Általános Orvostudományi Kar; Koncz, Gábor; Általános Orvostudományi Kar::Immunológiai IntézetThis study explores the role of hyperpolarization-activated cyclic nucleotide-gated HCN channels in macrophage inflammation and their potential impact on intestinal motility. While HCN2 inhibition is known to decrease intestinal motility, its involvement in the development of ileus remains unclear. The research focused on HCN channels, particularly HCN2, which are crucial for cellular excitability and pacemaking, and are now recognized for their role in immune modulation. THP1 cells were treated with the HCN channel blocker ZD7288 or a vehicle control (DMSO) and subjected to cyclic stretch, with cytokine release measured to assess inflammation. Using the FlexCell system to apply mechanical stretch to activated THP1 cells, results showed a significant reduction in macrophage cytokine release following HCN2 inhibition. These findings enhance our understanding of HCN2 channels in macrophage inflammation and suggest their potential as therapeutic targets.