Szerző szerinti böngészés "Issatayeva, Ingkar"

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    Human induced pluripotent stem cells: from reprograming of somatic cells to advanced gene editing technologies
    Issatayeva, Ingkar; Gyula, Batta; DE--Természettudományi és Technológiai Kar--Biotechnológiai Intézet
    Almost 17 years ago, a method for obtaining human-induced pluripotent stem cells (hiPSC) was developed, and since then, cell differentiation methods have also improved significantly every year. The most important value of iPSC was that it influenced the rapid development of science in the study of various human diseases. After all, the use of primary human cells or animal models is not totally suitable for basic research to determine the pathophysiology of a disease. Especially considering that the primary human cells caused dissonance in society and led to ethical issues, and it was also difficult to have access to all types of cells. Regarding animal models, primarily mice were used, whose phenotypes and biological reactions are distinct from those of humans. The use of hiPSCs has solved these problems, and due to their ability to be maintained indefinitely in cultures and their ability to differentiate into almost any cell type, new possibilities for their use have emerged such as gene therapy and drug screening.