Szerző szerinti böngészés "Javaid, Mahnoor"

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    Characteristics of emerging new autoimmune diseases after COVID‐19 vaccination: A sub‐study by the COVAD group
    Shumnalieva, Russka; Ravichandran, Naveen; Hannah, Jennifer; Javaid, Mahnoor; Darooka, Naitica; Roy, Debaditya; Gonzalez, Daniel E.; Velikova, Tsvetelina; Milchert, Marcin; Kuwana, Masataka; Joshi, Mrudula; Gracia‐Ramos, Abraham Edgar; Boyd, Peter; Yaadav, Praggya; Cheng, Karen; Kobert, Linda; Cavagna, Lorenzo; Sen, Parikshit; Day, Jessica; Makol, Ashima; Gutiérrez, Carlos Enrique Toro; Caballero‐Uribe, Carlo V.; Saha, Sreoshy; Parodis, Ioannis; Dey, Dzifa; Nikiphorou, Elena; Distler, Oliver; Kadam, Esha; Tan, Ai Lyn; Shinjo, Samuel Katsuyuki; Ziade, Nelly; Knitza, Johannes; Chinoy, Hector; Aggarwal, Rohit; Agarwal, Vikas; Gupta, Latika; Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus); Belgyógyászati Intézet -- 84; Klinikai Immunológiai Tanszék -- 60; ÁOK; Debreceni Egyetem
    Background Despite the overall safety and efficacy of COVID-19 vaccinations, rare cases of systemic autoimmune diseases (SAIDs) have been reported post-vaccination. This study used a global survey to analyze SAIDs in susceptible individuals' post-vaccination. Methods A cross-sectional study was conducted among participants with self-reported new-onset SAIDs using the COVID-19 Vaccination in Autoimmune Diseases (COVAD) 2 study dataset—a validated, patient-reported e-survey—to analyze the long-term safety of COVID-19 vaccines. Baseline characteristics of patients with new-onset SAIDs and vaccinated healthy controls (HCs) were compared after propensity score matching based on age and sex in a 1:4 ratio. Results Of 16 750 individuals, 74 (median age 52 years, 79.9% females, and 76.7% Caucasians) had new-onset SAID post-vaccination, mainly idiopathic inflammatory myopathies (IIMs) (n = 23, 31.51%), arthritis (n = 15; 20.53%), and polymyalgia rheumatica (PMR) (n = 12, 16.40%). Higher odds of new-onset SAIDs were noted among Caucasians (OR = 5.3; 95% CI = 2.9–9.7; p < .001) and Moderna vaccine recipients (OR = 2.7; 95% CI = 1.3–5.3; p = .004). New-onset SAIDs were associated with AID multimorbidity (OR = 1.4; 95% CI = 1.1–1.7; p < .001), mental health disorders (OR = 1.6; 95% CI = 1.3–1.9; p < .001), and mixed race (OR = 2.2; 95% CI = 1.2–4.2; p = .010), where those aged >60 years (OR = 0.6; 95% CI = 0.4–0.8; p = .007) and from high/medium human development index (HDI) countries (compared to very high HDI) reported fewer events than HCs. Conclusion This study reports a low occurrence of new-onset SAIDs following COVID-19 vaccination, primarily IIMs, PMR, and inflammatory arthritis. Identified risk factors included pre-existing AID multimorbidity, mental health diseases, and mixed race. Revaccination was well tolerated by most patients; therefore, we recommend continuing COVID-19 vaccination in the general population. However, long-term studies are needed to understand the autoimmune phenomena arising post-vaccination.
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    COVID-19 breakthrough infections in type 1 diabetes mellitus: a cross-sectional study by the COVID-19 Vaccination in Autoimmune Diseases (COVAD) Group
    (2023) Panchawagh, Suhrud; Ravichandran, Naveen; Barman, Bhupen; Nune, Arvind; Javaid, Mahnoor; Gracia-Ramos, Abraham Edgar; Day, Jessica; Joshi, Mrudula; Kuwana, Masataka; Saha, Sreoshy; Pande, Arunkumar R.; Caballero-Uribe, Carlo Vinicio; Velikova, Tsvetelina; Parodis, Ioannis; Knitza, Johannes; Kadam, Esha; Tan, Ai Lyn; Shinjo, Samuel Katsuyuki; Boro, Hiya; Aggarwal, Rohit; Agarwal, Vikas; Chatterjee, Tulika; Gupta, Latika; Griger, Zoltán; Nagy-Vincze, Melinda