Szerző szerinti böngészés "Kiss, Attila Jr"

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    Comparison of different methods in sampling and sample preparation of Chlorpromazine from biological matrix
    Nguyen, Thai Minh Hoang Jr; Nguyen, Thai Minh Hoang Jr; Bak, István Jr; Bak, István Jr; Debreceni Egyetem::Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; DE--Gyógyszerésztudományi Kar; Kiss, Attila Jr; Kiss, Attila Jr; Debreceni Egyetem::Természettudományi és Technológiai Kar::Kémiai Intézet; Debreceni Egyetem::Természettudományi és Technológiai Kar::Kémiai Intézet
    In this thesis, the efficiency and operational aspects of 2 extraction methods, microextraction by packed sorbent (MEPS) and solid-phase microextraction (SPME), were compared by their performance in quantifying chlorpromazine (CPZ) concentration of rat plasma samples. The extracts were then be analyzed by GCMS. Unfortunately, the GCMS instrument had a technical dysfunction before the final experiments could be performed. Despite that, it is shown that although it required a more complicated method development, SPME has better accuracy when analyzing the CPZ content of the samples than MEPS. However, the study still needs further investigation for strengthening the findings