Szerző szerinti böngészés "Mathew, Johan George"

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    Interpretation of the Response to Cardiac Resynchronization Therapy and Improvement of Therapeutic Options in Heart Failure
    Mathew, Johan George; Szuromi , Lilla; Szabó, Krisztina Mária; Általános Orvostudományi Kar::Kardiológiai Intézet::Kardiológiai Tanszék; DE--Általános Orvostudományi Kar; Orosz, Viktória; Bajdik, Beáta; Általános Orvostudományi Kar::Belgyógyászati Intézet; Általános Orvostudományi Kar::Szemészeti Tanszék
    This thesis addresses a critical challenge in heart failure (HF) management: non-responders to Cardiac Resynchronization Therapy (CRT) often face poor prognoses due to the lack of standardized success criteria. By reviewing updated guidelines, it redefines outdated "responder" and "non-responder" labels, introducing categories like "non-progressors" (who stabilize) and "progressors" (who worsen) for more accurate patient evaluation. The work explores multifactorial causes of inadequate CRT responses, including patient selection, technical factors related to implantation, programming details and device optimisation, CRT optimised by conduction system stimulation, appropriate management of comorbidities and optimisation of drug therapy. It emphasizes a multidisciplinary approach to improve outcomes, such as reducing hospitalizations, mortality rates and improving quality of life for HF patients with reduced ejection fraction.