Szerző szerinti böngészés "Merazga , Rim"

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    Effect of Competition of Nuclear Receptors in Phosphate-Mediated Ectopic Calcification in Calcific Aortic Valve Disease
    Merazga , Rim; György, Vámosi; Arpan, Chowdhury; Általános Orvostudományi Kar::Biofizikai és Sejtbiológiai Intézet; DE--Általános Orvostudományi Kar; Jambrovics, Károly; Általános Orvostudományi Kar::Biokémiai és Molekuláris Biológiai Intézet
    Bone calcification is a physiological process where calcium salts are deposited within collagen fibers in bones and teeth in the form of hydroxyapatite crystals. However, under pathological conditions such as chronic kidney disease (CKD), calcium salts accumulate and deposit in soft tissues ( such as the brain, eyes, and heart ) in a process called ectopic calcification. This abnormal biomineralization, which is driven by hyperphosphatemia and hypocalcemia, poses serious health risks, including cardiovascular complications like calcific aortic valve disease (CAVD). Vitamin D, another known inducer of calcification, is generally used as a supplement during CKD to maintain bone health. Vitamin D receptor (VDR) needs to heterodimerize with Retinoid X Receptor (RXR) for its function, like some other nuclear receptors (NRs) such as Peroxisome Proliferator-Activated Receptor Gamma (PPARγ), Retinoic Acid Receptor (RAR), etc. It is also proven that nuclear receptors compete for heterodimerization with RXR in a ligand-dependent manner. Based on the above-mentioned information, we ask whether VDR agonist induces aortic valve calcification? And if agonists of other NRs (RAR, PPARγ) influence this process?