Szerző szerinti böngészés "Ngo, Minh Toan"

Megjelenítve 1 - 7 (Összesen 7)
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    HER2 expression in different cell lines at different inoculation sites assessed by [52Mn]Mn-DOTAGA(anhydride)-trastuzumab
    (2025) Ngo, Minh Toan; Vágner, Adrienn; Nagy, Gábor; Ország, Gábor; Nagy, Tamás; Szoboszlai, Zoltán; Csikos, Csaba; Váradi, Balázs; Trencsényi, György; Tircsó, Gyula; Garai, Ildikó
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    In Vivo Preclinical Assessment of the VEGF Targeting Potential of the Newly Synthesized [52Mn]Mn-DOTAGA-Bevacizumab Using Experimental Cervix Carcinoma Mouse Model
    (2023) Csikos, Csaba; Vágner, Adrienn; Nagy, Gábor; Kálmán-Szabó, Ibolya; Péli-Szabó, Judit; Ngo, Minh Toan; Szoboszlai, Zoltán; Szikra, Dezső Péter; Krasznai, Zoárd Tibor; Trencsényi, György; Garai, Ildikó
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    Integrating Metabolic, Neo-Angiogenic, and HER2-Targeted Imaging to Characterize Breast Cancer in Preclinical Models
    (2025/11/18) Ngo, Minh Toan; Garai, Ildikó; Petrányi Gyula Klinikai immunológiai és allergológiai doktori iskola; Általános Orvostudományi Kar::Orvosi Képalkotó Intézet::Nukleáris Medicina Tanszék
    Background: Breast cancer is a highly heterogeneous disease, necessitating advanced imaging techniques for effective diagnosis and treatment. The visualization of metabolic activity, angiogenesis, and biomarkers such as HER2 expression provides critical insights into tumor behavior. This study integrates three molecular imaging approaches to explore tumor heterogeneity, focusing on metabolic activity, angiogenesis, their possible relationship, and HER2 expression in preclinical breast cancer models. Materials and Methods:(1) The relationship between metabolic activity and angiogenesis was assessed using [18F]FDG and [68Ga]Ga-NODAGA-c(RGDfK)2 (RGD) PET imaging in fast-growing 4T1 and slow-growing MDA-MB-HER2+ xenografts. Tumor/muscle ratios were analyzed using the Muscle-Spacing Correction Method. (2) HER2-targeted imaging with [52Mn]Mn-DOTAGA(anhydride)-trastuzumab was evaluated in orthotopic and ectopic MDA-MB-HER2+ and MDA-MB-468 (HER2-negative) xenografts. Tumor-to-background ratios were calculated, with melanoma xenografts serving as a specificity control. (3) A novel Mn(II) chelator, BPPA, was compared to DOTAGA-pSCN-Bn for [52Mn]Mn-trastuzumab labeling. Tumor-to-background ratios and tumor uptake were analyzed in 4T1 (HER2−) and MDA-MB-HER2+ xenografts. Results: (1) In the 4T1 group, both FDG and RGD imaging revealed highly heterogeneous tumor structures with correlations between uptake and tumor growth. FDG and RGD uptake showed relative linear correlations in all the tumors, with 4T1 showing higher FDG/RGD ratios compared to MDA-MB-HER2+. (2) [52Mn]Mn-DOTAGA(anhydride)-trastuzumab demonstrated higher tumor-to-background ratios in orthotopic HER2-positive tumors, showing consistently superior uptake compared to ectopic HER2-positive tumors, HER2-negative tumor and melanoma at all-time points. (3) The novel BPPA chelator significantly outperformed DOTAGA-pSCN-Bn in tumor imaging with [52Mn]Mn-BPPA-trastuzumab showing significantly superior tumor-to-background ratios. Using BPPA tracer, HER2+ tumor uptake remained higher than HER2− at all time points, with a 3–4 fold higher contrast over HER2− tumors by day 7, establishing its potential for extended imaging windows and earlier detection compared to the DOTAGA chelator. Conclusion: Integrating metabolic, angiogenic, and receptor-targeted imaging offers a comprehensive approach to characterizing breast cancer heterogeneity. The combination of [18F]FDG, RGD, and [52Mn]Mn-based radiotracers, especially with BPPA chelator, demonstrates the potential to improve imaging precision and optimize treatment strategies.
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    Novel ultrasound techniques
    Ngo, Minh Toan; Vrancsik, Nóra; Debreceni Egyetem::Általános Orvostudományi Kar::Radiológiai Klinika; DE--Általános Orvostudományi Kar; Kretzer, András; Lánczi, Levente István; Debreceni Egyetem::Általános Orvostudományi Kar::Radiológiai Klinika; Kenézy Kórház, Radiológia
    Elastography is a novel ultrasound technique which has been gaining a lot of attention in recent years. It is still a developing ultrasound technique that has evolved into a clinically useful technique in ultrasound machines. It provides stiffness measurements of investigated tissues, with four main methods in our days. Since many pathological conditions alter the tissues’ structure and change stiffness, this modality can improve diagnosis with greater confidence.
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    The Impact of Chemotherapy on Cardiovascular Mortality across Breast Cancer Subtypes
    (2024) Ngo, Minh Toan; Lê, Ánh Ngọc; Đinh, Dương Phạm Hoàng
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    The Relationship of Metabolic Activity and αvβ3 Receptor Expression in Aggressive Breast Cancer Subtypes Tumors: a Preliminary Report
    (2025) Ngo, Minh Toan; Nagy, Tamás; Szoboszlai, Zoltán; Csikos, Csaba; Dénes, Noémi; Furka, Andrea; Trencsényi, György; Garai, Ildikó