Szerző szerinti böngészés "Nyakundi, Bogonko Benard"

Megjelenítve 1 - 1 (Összesen 1)
  • Bélyegkép
    TételSzabadon hozzáférhető
    The impact of hemoglobin oxidation in NLRP3 inflammasome activation upon intravascular hemolysis
    (2020) Nyakundi, Bogonko Benard; Viktoria, Jeney; Molekuláris sejt- és immunbiológia doktori iskola; DE--Általános Orvostudományi Kar -- Research Centre for Molecular Medicine
    In this work, we demonstrated that following intravascular hemolysis Hb oxidation leads to the formation of hemichrome, metHb, covalently cross-linked Hb multimers, and free heme. We showed that PHZ-induced IVH triggers IL-1 production via the NLRP3 inflammasome activation. We demonstrated that covalently cross-linked Hb forms during the decomposition of transient ferrylHb the molecules we proposed to name as gmoxHb. We Identified gmoxHb as a potent pro-inflammatory Hb form which induced the active production of IL-1 in vivo and in vitro. We confirmed that NLRP3 deficiency confers a survival advantage to mice in PHZ-induced IVH via increased tolerance and improved tissue damage control mechanisms. Identification of RBC-derived DAMPs and understanding the signaling mechanisms involved in the pathophysiology might provide new approaches for the treatment of IVH-related pathological conditions.