Szerző szerinti böngészés "Shaw, Abhirup"
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Tétel Szabadon hozzáférhető ASC-1 transporter-dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation(2021) Arianti, Rini; Vinnai, Boglárka Ágnes; Bartáné Tóth, Beáta; Shaw, Abhirup; Csősz, Éva; Vámos, Attila; Győry, Ferenc; Fischer-Posovszky, Pamela; Wabitsch, Martin; Kristóf, Endre; Fésüs, LászlóTétel Korlátozottan hozzáférhető BMP7 increases UCP1-dependent and independent thermogenesis with a unique gene expression program in human neck area derived adipocytes(2021) Shaw, Abhirup; Bartáné Tóth, Beáta; Arianti, Rini; Csomós, István; Póliska, Szilárd; Vámos, Attila; Bacsó, Zsolt; Győry, Ferenc; Fésüs, László; Kristóf, EndreTétel Szabadon hozzáférhető Corrigendum: Human abdominal subcutaneous-derived active beige adipocytes carrying FTO rs1421085 obesity-risk alleles exert lower thermogenic capacity(2023) Vámos, Attila; Arianti, Rini; Vinnai, Boglárka Ágnes; Alrifai, Rahaf; Shaw, Abhirup; Póliska, Szilárd; Guba, Andrea; Csősz, Éva; Csomós, István; Mocsár, Gábor; Lányi, Cecília; Balajthy, Zoltán; Fésüs, László; Kristóf, EndreTétel Szabadon hozzáférhető Editorial: Novel regulatory mechanisms behind thermogenesis of brown and beige adipocytes(2023) Shaw, Abhirup; Kristóf, Endre; Cereijo, RubénTétel Korlátozottan hozzáférhető FTO intronic SNP strongly influences human neck adipocyte browning determined by tissue and PPARγ specific regulation: a transcriptome analysis(2020) Bartáné Tóth, Beáta; Arianti, Rini; Shaw, Abhirup; Vámos, Attila; Veréb, Zoltán; Póliska, Szilárd; Győry, Ferenc; Bacsó, Zsolt; Fésüs, László; Kristóf, EndreTétel Szabadon hozzáférhető Human Abdominal Subcutaneous-Derived Active Beige Adipocytes Carrying FTO rs1421085 Obesity-Risk Alleles Exert Lower Thermogenic Capacity(2023) Vámos, Attila; Arianti, Rini; Vinnai, Boglárka Ágnes; Alrifai, Rahaf; Shaw, Abhirup; Póliska, Szilárd; Guba, Andrea; Csősz, Éva; Csomós, István; Mocsár, Gábor; Lányi, Cecília; Balajthy, Zoltán; Fésüs, László; Kristóf, EndreTétel Szabadon hozzáférhető Identification of unique molecular signature ofbrowning in human primary adipocytes fromdeep and subcutaneous neck fat(2019) Arianti, Rini; Shaw, Abhirup; Vámos, Attila; Bartáné Tóth, Beáta; Győry, Ferenc; Póliska, Szilárd; Kristóf, Endre; Fésüs, LászlóTétel Korlátozottan hozzáférhető Interleukin-6 released from differentiating human beige adipocytes improves browning(2019) Kristóf, Endre; Klusóczki, Ágnes; Veress, Roland; Shaw, Abhirup; Combi, Zsolt; Varga, Klára; Győry, Ferenc; Balajthy, Zoltán; Bai, Péter; Bacsó, Zsolt; Fésüs, LászlóTétel Korlátozottan hozzáférhető Irisin stimulates the release of CXCL1 from differentiating human subcutaneous and deep-neck derived adipocytes via upregulation of NF[kappa]B pathway(2021) Shaw, Abhirup; Bartáné Tóth, Beáta; Király, Róbert; Arianti, Rini; Csomós, István; Póliska, Szilárd; Vámos, Attila; Korponay-Szabó, Ilma; Bacsó, Zsolt; Győry, Ferenc; Fésüs, László; Kristóf, EndreTétel Szabadon hozzáférhető Mitophagy Mediates the Beige to White Transition of Human Primary Subcutaneous Adipocytes Ex Vivo(2022) Vámos, Attila; Shaw, Abhirup; Varga, Klára; Csomós, István; Mocsár, Gábor; Balajthy, Zoltán; Lányi, Cecília; Bacsó, Zsolt; Szatmári-Tóth, Mária; Kristóf, EndreTétel Korlátozottan hozzáférhető Thermogenic Activation Downregulates High Mitophagy Rate in Human Masked and Mature Beige Adipocytes(2020) Szatmári-Tóth, Mária; Shaw, Abhirup; Csomós, István; Mocsár, Gábor; Fischer-Posovszky, Pamela; Wabitsch, Martin; Balajthy, Zoltán; Lányi, Cecília; Győry, Ferenc; Kristóf, Endre; Fésüs, LászlóTétel Szabadon hozzáférhető Thermogenic regulation of human abdominal and neck area derived adipocytes by mitophagy, irisin and BMP7Shaw, Abhirup; Fésüs, László; Molekuláris sejt- és immunbiológia doktori iskola; DE--Általános Orvostudományi Kar -- Biokémiai és Molekuláris Biológiai IntézetObesity, defined by disproportionate body weight for height with an excessive accumulation of adipose tissue, is considered by many as a 21st century epidemic. The incidence of obesity is increasing globally over the past decades. It is one of the most important risk factors contributing to the overall disease burden worldwide. Obesity is a major risk factor for various metabolic diseases, type 2 diabetes, coronary heart disease, and certain cancers. Although the prevalence of obesity is increasing worldwide, available effective therapeutic targets are limited. Adipocytes can be broadly classified into three types: white, brown, or beige adipocytes. White adipocytes primarily function as energy storage, while beige and brown adipocytes dissipate excess stored energy in the form of heat, also known as thermogenesis. Beige and brown adipocytes perform thermogenesis by the action of uncoupling protein 1 (UCP1), however, UCP1 independent mechanisms are also known and becoming increasingly important. So, thermogenic beige and brown adipocytes play an important role in combating obesity. White adipocytes can be transformed to beige adipocytes, termed “beiging”, under the action of browning inducers like adrenergic stimulation, irisin, or BMP7. In our study, we have shown that cAMP mediated adrenergic stimulus induces beiging of human abdomen derived white and brown differentiated adipocytes by repressing mitophagy, that is continuous removal of heat generating mitochondria. Another promising browning inducer, irisin, stimulates the release of a novel adipokine CXCL1 from human neck area derived differentiating adipocytes. The released CXCL1 was further shown to improve adhesion capacity of endothelial cells. BMP7, a well-known browning inducer can promote a strong thermogenic response in human neck derived adipocytes via UCP1 dependent and independent mechanisms.