Szerző szerinti böngészés "Singh, Parvind"
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Tétel Szabadon hozzáférhető A Comprehensive Investigation of Stimulatory Agents on MAIT and Vα7.2+/CD161-T Cell Response and Effects of Immunomodulatory Drugs(2024) Singh, Parvind; Széles, Mariann; Baráth, Sándor; Hevessy, ZsuzsannaTétel Szabadon hozzáférhető Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, [gamma][delta] T cells, and mucosa-associated invariant T cells(2022) Singh, Parvind; Széles, Mariann; Mezei, Zoltán András; Baráth, Sándor; Hevessy, ZsuzsannaTétel Szabadon hozzáférhető Case report: Complex evaluation of coagulation, fibrinolysis and inflammatory cytokines in a SARS-CoV-2 infected pregnant woman with fetal loss(2024) Tóth, Eszter Lilla; Orbán-Kálmándi, Rita Angéla; Bagoly, Zsuzsa; Lóczi, Linda; Deli, Tamás; Török, Olga; Deliné Molnár, Sarolta; Baráth, Sándor; Singh, Parvind; Hevessy, Zsuzsanna; Katona, Éva; Fagyas, Miklós; Szabó, Attila Ádám; Molnár, Szabolcs; Krasznai, Zoárd TiborTétel Szabadon hozzáférhető Complex evaluation of coagulation, fibrinolysis, and inflammatory cytokines in SARS-CoV-2 infected pregnant women: a prospective, case-control study(2025) Bagoly, Zsuzsa; Tóth, Eszter Lilla; Orbán-Kálmándi, Rita Angéla; Lóczi, Linda; Deli, Tamás; Török, Olga; Kozma, Bence; Baráth, Sándor; Singh, Parvind; Hevessy, Zsuzsanna; Tóth, Judit; Katona, Éva; Molnár, Szabolcs; Krasznai, Zoárd TiborTétel Szabadon hozzáférhető Dynamic P-glycoprotein expression in early and late memory states of human CD8+T cells and the protective role of ruxolitinib(2025) Biwott, Kipchumba; Singh, Parvind; Baráth, Sándor; Nyariki, James Nyabuga; Hevessy, Zsuzsanna; Bacsó, ZsoltTétel Szabadon hozzáférhető Investigating Vα7.2+/CD161- T Cell and MAIT Cell Profiles Using Flow Cytometry in Healthy Subjects and Subjects with Atopic Dermatitis(2024) Singh, Parvind; Gáspár, Krisztián; Szegedi, Andrea; Sajtos, László; Baráth, Sándor; Hevessy, ZsuzsannaTétel Szabadon hozzáférhető Unconventional T cells in health and diseases(2024) Singh, Parvind; Hevessy, Zsuzsanna; Laki Kálmán doktori iskola; Általános Orvostudományi Kar::Laboratóriumi Medicina IntézetTo summarize, the frequency of γδ and MAIT cells is higher in the younger age group, revealing a negative correlation with age and supporting the concept of immunosenescence. In contrast, iNKT cell frequency shows no statistically significant difference across age groups and no observable negative correlation with age. Gender-specific analysis uncovers higher levels of iNKT cells in females, exhibiting a negative correlation with age. In comparison, γδ T cells display higher levels in males, with both genders negatively correlating with age. MAIT cells, on the other hand, exhibit no gender-based differences and manifest a negative correlation with age in both males and females. The intriguing discovery of a positive correlation among uT cells lays a foundation for future studies exploring immune-mediated diseases and their relationship with uT cells. In vitro study revealed that MAIT cells were producing IL-13 in steady-state conditions and responded robustly to the 5-OP-RU ligand, specifically in the presence of proinflammatory cytokines (IL-12/33). Our in vitro experiments showed that MAIT cells regulate the surface expression of CD69 and CD38 and produce IFNγ and effector (TNFα/GzB) cytokines. We found a similar pattern of cell surface markers and cytokines in AD. This phenotype may correspond to an activated and fully differentiated effector cell type capable of producing cytokines and acting as a cytotoxic cell, suggesting their involvement in the pathomechanism of the disease. Cyclosporin A is a potent immunosuppressing agent that significantly blocks the proinflammatory cytokines in MAIT cells, while vitamin D3 could support MAIT cell activation and IL-13 production to bring steady-state conditions. Despite sharing the Vα7.2 compartment, MAIT cells and Vα7.2+/CD161- T cells show clear differences. Vα7.2+/CD161- T cells resemble conventional T cells and do not respond to 5-OP-RU, although PMA stimulation increases the production of certain cytokines.