Szerző szerinti böngészés "Yang, Ying"

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    Examing motivations to study abroad: chinese students at the university of debrecen
    Yang, Ying; Kun, András István; DE--Gazdaságtudományi Kar
    To analyze the students motivation to study abroad, this study first collected some data on international student mobility in recent years (UNESCO, 2022), the number of Chinese students studying abroad and China's economic development of GDP from the World Bank (2022), the choice of Chinese students' destination countries, and other related data from the National Bureau of Statistics of China (2020). It is found that with the development of China's economy, the choice of students' destination countries for study abroad is no longer singularly limited to some economic powers such as the United States, but the number of international students from many other countries has also started to grow rapidly. In this context, the analysis shows that the number of Chinese students studying in Hungary has been increasing year by year, and now the number of Chinese students has reached the second place (DNH, 2022). The analysis of the motivation of students coming to study in Hungary can help to solve these problems. Then conclusions are drawn by studying Chinese students who come to study at the University of Debrecen through the method of in-depth interviews. The innovation of this paper is to make a more in-depth exploratory analysis of the motivation of contemporary college students to study abroad based on the in-depth interview data of six Chinese students studying at Debrecen University and using the method of qualitative research. At the same time, it is based on the data from the Institute of International Education on the number of Chinese international students going abroad in 2022. It intuitively expands horizontally to analyze the main motives of international students studying abroad.
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    [S] Exploratory multi-omics analysis reveals host-microbe interactions associated with disease severity in psoriatic skin
    Yang, Ying; Olah, Peter; Radai, Zoltan; Maia, Guilherme; Salava, Alexander; Salo, Ville; Barker, Jonathan; Lauerma, Antti; Andersson, Björn; Homey, Bernhard; Fyhrquist, Nanna; Alenius, Harri; Radai Zoltán (2024-) (xxx); "Egy Egészség" Intézet -- 4504; ETK; Debreceni Egyetem
    Background: Psoriasis (Pso) is a chronic inflammatory skin disease that poses both physical and psychological challenges. Dysbiosis of the skin microbiome has been implicated in Pso, yet a comprehensive multi-omics analysis of host-microbe interactions is still lacking. To bridge this gap, we conducted an exploratory study by adopting the integrated approach that combines whole metagenomic shotgun sequencing with skin transcriptomics. Methods: This was a cross-sectional study, adult patients with plaque-type Psoriasis (Pso) and healthy volunteers were included. Skin microbiota samples and biopsies were collected from both lesional and non-lesional skin areas on the lower back. Weighted Gene Correlation Network Analysis (WGCNA) was employed for co-expression network analysis, and cell deconvolution was conducted to estimate cell fractions. Taxonomic and functional features of the microbiome were identified using whole metagenomic shotgun sequencing. Association between host genes and microbes was analyzed using Spearman correlation. Findings: Host anti-viral responses and interferon-related networks were identified and correlated with the severity of psoriasis. The skin microbiome showed a greater prevalence of Corynebacterium simulans in the PASI severe-moderate groups, which correlated with interferon-induced host genes. Two distinct psoriatic clusters with varying disease severities were identified. Variations in the expression of cell apoptosis-associated antimicrobial peptides (AMPs) and microbial aerobic respiration I pathway may partly account for these differences in disease severity. Interpretation: Our multi-omics analysis revealed for the first time anti-viral responses and the presence of C. simulans associated with psoriasis severity. It also identified two psoriatic subtypes with distinct AMP and metabolic pathway expression. Our study provides new insights into understanding the host-microbe interaction in psoriasis and lays the groundwork for developing subtype-specific strategies for managing this chronic skin disease. Funding: The research has received funding from the FP7 (MAARS–Grant 261366) and the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 821511 (BIOMAP). The JU receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA. This publication reflects only the author's view and the JU is not responsible for any use that may be made of the information it contains. GAM was supported by a scholarship provided by CAPES-PRINT, financed by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES (Brazilian Government Agency). The authors thank all patients who participated in our study. © 2024