Szerző szerinti böngészés "Zarjou, Abolfazl"
Megjelenítve 1 - 17 (Összesen 17)
Találat egy oldalon
Rendezési lehetőségek
Tétel Szabadon hozzáférhető A Reproducible Mouse Model of Moderate CKD With Early Manifestations of Osteoblastic Transition of Cardiovascular System(2022) Machado, Sarah E.; Spangler, Daryll; Black, Laurence M.; Traylor, Amie M.; Balla, József; Zarjou, AbolfazlTétel Szabadon hozzáférhető Counteraction of Myocardial Ferritin Heavy Chain Deficiency by Heme Oxygenase-1(2022) Machado, Sarah E.; Spangler, Daryll; Stacks, Delores A.; Darley-Usmar, Victor; Benavides, Gloria A.; Xie, Min; Balla, József; Zarjou, AbolfazlTétel Szabadon hozzáférhető Ferritin in Kidney and Vascular Related Diseases: novel Roles for an Old Player(2019) Balla, József; Balla, György; Zarjou, AbolfazlTétel Szabadon hozzáférhető Ferritin Light Chain Confers Protection Against Sepsis-Induced Inflammation and Organ Injury(2019) Zarjou, Abolfazl; Black, Laurence M.; McCullough, Kayla R.; Hull, Travis D.; Esman, Stephanie K.; Boddu, Ravindra; Varambally, Sooryanarayana; Chandrashekar, Darshan S.; Feng, Wenguang; Arosio, Paolo; Poli, Maura; Balla, József; Bolisetty, SubhashiniTétel Szabadon hozzáférhető Ferritin Light Chain Confers Protection Against Sepsis-Induced Inflammation and Organ InjuryZarjou, Abolfazl; Black, Laurence M.; McCullough, Kayla R.; Hull, Travis D.; Esman, Stephanie K.; Boddu, Ravindra; Varambally, Sooryanarayana; Chandrashekar, Darshan S.; Feng, Wenguang; Arosio, Paolo; Poli, Maura; Balla, Jozsef; Bolisetty, Subhashini; Balla József (1959-) (belgyógyász, nephrológus); Belgyógyászati Intézet -- 84; Nephrológiai Nem Önálló Tanszék -- 53; ÁOK; Debreceni EgyetemTétel Korlátozottan hozzáférhető Ferritin: a potent inhibitor of vascular calcification and osteoblast activity(2014) Zarjou, Abolfazl; Balla, József; Laki Kálmán doktori iskola; DE--Általános Orvostudományi Kar -- Belgyógyászati Intézet Nephrológiai TanszékVascular calcification plays a role in the pathogenesis of atherosclerosis, diabetes, and chronic kidney disease. Human aortic smooth muscle cells (SMCs) undergo mineralization in response to elevated levels of inorganic phosphate (Pi) in an active and well-regulated process that involves increased activity of alkaline phosphatase and increased expression of core binding factor alpha-1 (Cbfa-1), a bone-specific transcription factor, with the subsequent induction of osteocalcin. Mounting evidence suggests an essential role for the heme oxygenase 1 (HO-1)/ferritin system to maintain homeostasis of vascular function. We examined whether induction of HO-1 and ferritin alters mineralization of SMCs provoked by high Pi. Upregulation of the HO-1/ferritin system inhibited HSMC calcification and osteoblastic differentiation. Of the products of the system, only ferritin and, to a lesser extent, biliverdin were responsible for the inhibition. We conclude that induction of the HO-1/ferritin system prevents Pi-mediated calcification and osteoblastic differentiation of SMCs mainly via the ferroxidase activity of ferritin. These findings prompted us to study the mechanism of iron induced bone defects. While iron overload and its association with osteoporosis has long been recognized, the pathogenesis and exact role of iron have been undefined. Osteoblast (OB) development and maturation are under the influence of Cbfa-1, which induces expression of OB-specific genes. We demonstrate that iron-provoked inhibition of OB activity is mediated by ferritin and its ferroxidase activity. We confirm this notion by using purified ferritin H-chain and ceruloplasmin, both known to possess ferroxidase activity that inhibited calcification, whereas a site-directed mutant of ferritin H-chain lacking ferroxidase activity failed to provide any inhibition. Furthermore, we report that such suppression is not restricted to inhibition of calcification, but OB-specific genes such as alkaline phosphatase, osteocalcin, and Cbfa-1 are all downregulated by ferritin in a dose-responsive manner. This study corroborates that iron decreases mineralization and demonstrates that this suppression is provided by iron-induced upregulation of ferritin and its ferroxidase activity.Tétel Szabadon hozzáférhető Ferryl Hemoglobin Inhibits Osteoclastic Differentiation of Macrophages in Hemorrhaged Atherosclerotic Plaques(2020) Zavaczki, Erzsébet; Gáll, Tamás; Zarjou, Abolfazl; Hendrik, Zoltán; Potor, László; Tóth, Csaba; Méhes, Gábor; Gyetvai, Ágnes; Agarwal, Anupam; Balla, György; Balla, JózsefTétel Szabadon hozzáférhető Heme Burden and Ensuing Mechanisms That Protect the Kidney: insights from Bench and Bedside(2021) Balla, József; Zarjou, AbolfazlTétel Szabadon hozzáférhető Hemodiafiltration and hemodialysis differently affect P wave duration and dispersion on the surface electrocardiogram(2016) Páll, Alida; Czifra, Árpád; Borbásné Sebestyén, Veronika; Becs, Gergely; Kun, Csaba; Balla, József; Paragh, György; Lőrincz, István; Páll, Dénes; Padra, János Tamás; Agarwal, Anupam; Zarjou, Abolfazl; Szabó, ZoltánTétel Korlátozottan hozzáférhető Hemodiafiltration beneficially affects QT interval duration and dispersion compared to hemodialysis(2014) Barta, Kitti; Czifra, Árpád; Kun, Csaba; Páll, Alida; Kulcsár, Júlia; Paragh, György; Lőrincz, István; Padra, János Tamás; Agarwal, Anupam; Zarjou, Abolfazl; Balla, József; Szabó, ZoltánTétel Szabadon hozzáférhető Hemodialysis and hemodiafiltration differently modulate left ventricular diastolic function(2013) Czifra, Árpád; Páll, Alida; Kulcsár, Júlia; Barta, Kitti; Kertész, Attila Béla; Paragh, György; Lőrincz, István; Jenei, Zoltán; Agarwal, Anupam; Zarjou, Abolfazl; Balla, József; Szabó, ZoltánTétel Korlátozottan hozzáférhető Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease(2020) Sikura, Katalin Éva; Potor, László; Szerafin, Tamás; Oros, Melinda; Nagy, Péter; Méhes, Gábor; Hendrik, Zoltán; Zarjou, Abolfazl; Agarwal, Anupam; Posta, Niké; Torregrossa, Roberta; Whiteman, Matthew; Fürtös, Ibolya; Balla, György; Balla, JózsefTétel Szabadon hozzáférhető Macrophage ferritin heavy chain/α-synuclein regulatory axis modulates ferroptosis during kidney injury(2026) Chatterjee, Tanima; Machado, Sarah E.; Cowen, Kellen; Miller, Mary; Johnson, Bronte; Zhang, Yanfeng; Volpicelli-Daley, Laura; Fielding, Lauren; Pattanayak, Rudradip; Rosenblum, Frida; Potor, László; Balla, György; Balla, József; Faul, Christian; Zarjou, AbolfazlTétel Szabadon hozzáférhető Pharmacological induction of ferritin prevents osteoblastic transformation of smooth muscle cells(2016) Becs, Gergely; Zarjou, Abolfazl; Agarwal, Anupam; Sikura, Katalin Éva; Becs, Ádám; Nyitrai, Mónika; Balogh, Enikő; Bányai, Emese; Eaton, John W.; Arosio, Paolo; Poli, Maura; Jeney, Viktória; Balla, József; Balla, GyörgyTétel Szabadon hozzáférhető Renal control of disease tolerance to malaria(2019) Ramos, Susana; Carlos, Ana Rita; Sundaram, Balamurugan; Jeney, Viktória; Ribeiro, Ana; Gozzelino, Raffaella; Bank, Claudia; Gjini, Erida; Braza, Faouzi; Martins, Rui; Ademolue, Temitope Wilson; Blankenhaus, Birte; Gouveia, Zélia; Faísca, Pedro; Trujillo, Damian; Cardoso, Sílvia; Rebelo, Sofia; del Barrio, Laura; Zarjou, Abolfazl; Bolisetty, Subhashini; Agarwal, Anupam; Soares, Miguel P.Tétel Szabadon hozzáférhető The disparate effect of hemodialysis and hemodiafiltration on T-wave-peak-to-end interval (Tpe) and Tpe/QT ratio of the surface electrocardiogram(2017) Páll, Alida; Borbásné Sebestyén, Veronika; Czifra, Árpád; Becs, Gergely; Anupam, Agarwal; Zarjou, Abolfazl; Paragh, György; Lőrincz, István; Balla, József; Szabó, ZoltánTétel Szabadon hozzáférhető Zinc Inhibits HIF-Prolyl Hydroxylase Inhibitor-Aggravated VSMC Calcification Induced by High Phosphate(2020) Nagy, Annamária; Pethő, Dávid; Gáll, Tamás; Zavaczki, Erzsébet; Nyitrai, Mónika; Posta, József; Zarjou, Abolfazl; Agarwal, Anupam; Balla, György; Balla, József