Szerző szerinti böngészés "Zhang, Changsheng"
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Tétel Szabadon hozzáférhető Flavin-enabled reductive and oxidative epoxide ring opening reactions(2022) De, Bidhan Chandra; Zhang, Wenjun; Yang, Chunfang; Mándi, Attila; Huang, Chunshuai; Zhang, Liping; Liu, Wei; Ruszczycky, Mark W.; Zhu, Yiguang; Ma, Ming; Bashiri, Ghader; Kurtán, Tibor; Liu, Hung-wen; Zhang, ChangshengTétel Szabadon hozzáférhető Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the α/β-fold epoxide hydrolase Alp1U(2020) Zhang, Liping; De, Bidhan Chandra; Zhang, Wenjun; Mándi, Attila; Fang, Zhuangjie; Yang, Chunfang; Zhu, Yiguang; Kurtán, Tibor; Zhang, ChangshengTétel Szabadon hozzáférhető Stereoselective Synthesis of Axially Chiral 5,5′-Linked bis-1-Arylisochromans with Antibacterial ActivityCzenke, Zoltán; Mándi, Attila; Fedics, Gergely Miklós; Barta, Roland Albert; Kiss-Szikszai, Attila; Kurucz-Szabados, Anna; Timári, István; Bényei, Attila; Király, Sándor Balázs; Ostorházi, Eszter; Zhang, Changsheng; Kicsák, Máté; Kurtán, Tibor; Czenke Zoltán (1993-) (okleves vegyészmérnök, középiskolai kémiatanár); Kurtán Tibor (1973-) (vegyész, angol szakfordító); Kémiai Intézet -- 724; Szerves Kémiai Tanszék -- 729; TTK; Debreceni EgyetemInspired by naturally occurring bis-isochromans such as penicisteckins, we envisaged the first synthesis of biaryl-type bis-1-arylisochromans containing a stereogenic ortho-trisubstituted biaryl axis. We achieved the stereoselective synthesis of 5,5′-linked heterodimeric bis-isochromans containing both central and axial chirality elements by performing diastereoselective Suzuki–Miyaura biaryl coupling reactions on two optically active 1-arylpropan-2-ol derivatives, followed by two oxa-Pictet–Spengler cyclizations with aryl aldehydes or methoxymethyl chloride. We studied the diastereoselectivity of the cyclization step, separated the stereoisomeric products with chiral preparative HPLC and determined the absolute configuration through a combination of vibrational circular dichroism (VCD), NMR and single-crystal X-ray diffraction analysis. We demonstrated that different aryl groups could be introduced into the two isochroman subunits, since the dimethoxyaryl subunit reacted faster, enabling the two oxa-Pictet–Spengler cyclizations to be performed separately with different aryl aldehydes. We also explored the acid-catalyzed isomerization and oxidation to axially chiral ortho-quinones in order to produce stereoisomeric and oxidized analogs, respectively. We identified the antibacterial activity of our target bis-isochromans against Bacillus subtilis and Enterococcus faecalis with minimum inhibitory concentrations down to 4.0 and 0.5 μg/mL, respectively, which depend on the stereochemistry and substitution pattern of the bis-isochroman skeleton.Tétel Szabadon hozzáférhető VCD Analysis of Axial Chirality in Synthetic Stereoisomeric Biaryl-Type bis-Isochroman Heterodimers with Isolated Blocks of Central and Axial Chirality(2024) Czenke, Zoltán; Mándi, Attila; Király, Sándor Balázs; Kiss-Szikszai, Attila; Ábrahám, Anita; Szabados, Anna; Cserepes, Krisztián; Bényei, Attila; Zhang, Changsheng; Kicsák, Máté; Kurtán, Tibor