Review of Diffuse large B cell lymphoma, pharmacological aspects of treatment and comparison of outcome between Pre-,Post Rituximab era

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorKim, Gang Kyu
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentDrimba, László
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentdeptKenézy Kórház Aneszteziológiai és Intenziv Therápiás Osztályhu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.date.accessioned2017-08-03T08:31:10Z
dc.date.available2017-08-03T08:31:10Z
dc.date.created2017-02-17
dc.description.abstractDiffuse large B Cell lymphoma (DLBCL) is a type aggressive non-Hodgkin Lymphoma (NHL). About 30% of patients who diagnosed NHL is DLBCL in both male and female. It is divided into 3 major types which distinct by immunological characteristics. It shall shows variable spectrum of prognosis and response to the treatment due to gene expression variability. Nowadays Rituximab is the gold standard treatment of NHL which is targeting monoclonal antibody of CD20 and it also shows good prognosis to DLBCL. Rituximab containing chemotherapy regimen like R-CHOP shows relatively good response to DLBCL compare to pre-rituximab era and in rituximab era, overall relative survival rate was significantly increased compare to pre-rituximab era. Recently, further study about the treatment that adjusted to the gene mutation is in progress.hu_HU
dc.description.correctortben
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent28hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/242854
dc.language.isoenhu_HU
dc.subjectDiffuse large B cell lymphomahu_HU
dc.subjectRituximab
dc.subjectRCHOP
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleReview of Diffuse large B cell lymphoma, pharmacological aspects of treatment and comparison of outcome between Pre-,Post Rituximab erahu_HU
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