Theses (Faculty of Medicine)
Állandó link (URI) ehhez a gyűjteményhez
Theses collection of the Faculty of Medicine. The collection was started in 2014.
At the University of Debrecen, in accordance with the 2022 amendment to the 2011 Higher Education Act, student theses are only accessible from devices connected to the University's Eduroam WiFi network or from a university IP address.
“The thesis or diploma work of a student who has successfully passed the final examination shall be stored in full in the academic system of the higher education institution, and a record shall be maintained thereof. The stored theses and diploma works – with the exception of parts classified as confidential in accordance with the relevant legislation – must be made accessible and searchable without restriction through the academic system.” Further info on the National Higher Education Act in Hungarian: Felsőokt. tv. (új) - 2011. évi CCIV. törvény a nemzeti felsőoktatásról - Hatályos Jogszabályok Gyűjteménye.
Böngészés
legfrissebb feltöltések
Megjelenítve 1 - 20 (Összesen 1911)
Tétel Korlátozottan hozzáférhető Effects of Solar Particle Event Proton Exposure on Neuron-like Cells: Experimental Optimization and Early OutcomesZaikina, Yulia; Tar, Krisztina; Általános Orvostudományi Kar::Orvosi Vegytani Intézet; DE--Általános Orvostudományi Kar; Dienes , Beatrix; Általános Orvostudományi Kar::Élettani IntézetThis study investigated the effects of simulated Solar Particle Event (SPE) proton radiation on neuron-like SH-SY5Y cells to better understand potential central nervous system risks during long-duration space missions. The primary objective was to optimize an experimental proton irradiation model that reproduces SPE-relevant exposure conditions while generating preliminary biological data on neuronal radiation responses. SH-SY5Y cells were irradiated with 17 MeV protons using the MGC-20E cyclotron at the HUN-REN ATOMKI Accelerator Centre, while SRIM/TRIM Monte Carlo simulations were used to support and refine the experimental setup. During the project, sources of physical and biological variability affecting reproducibility were identified and more reliable irradiation conditions were established. The study's biological analyses showed dose-dependent effects on apoptosis, cell viability, and stress-related gene expression including cFOS transcription, and neuronal markers. Overall, the optimized irradiation model produced measurable biological responses under SPE-like conditions and provides a methodological foundation for future studies of SPE proton radiation effects on neuron-like cells.Tétel Korlátozottan hozzáférhető The Off-Target Effects of SGLT2 Inhibitors and Metformin on AMPK Activation and Intestinal ContractilityVije Vardana, Khashiya Khathoon; Docsa, Tibor; Uray, Karen Lee; Általános Orvostudományi Kar::Orvosi Vegytani Intézet; DE--Általános Orvostudományi KarThis study investigated the off-target effects of SGLT2 inhibitors and metformin on intestinal smooth muscle contractility, with particular emphasis on the role of AMP-activated protein kinase (AMPK). Ex vivo organ bath experiments were used to evaluate the effects of dapagliflozin and metformin on spontaneous and carbachol-induced contractions, while additional analyses examined the potential involvement of SGLT1/2 inhibition, the Na⁺/H⁺ exchanger (NHE), and AMPK signaling. Dapagliflozin significantly reduced intestinal contractility, and AMPK inhibition partially reversed this effect, suggesting that AMPK contributes to the observed response. However, the incomplete reversal indicates that additional mechanisms may also be involved, and biochemical confirmation of AMPK activation was not achieved within the study timeframe. These findings provide mechanistic insight into reduced intestinal contractility and suggest that AMPK activation contributes to the inhibitory effects of SGLT2 inhibition on intestinal motility. Understanding this relationship may help explain clinically observed gastrointestinal side effects and support strategies to improve patient adherence.Tétel Korlátozottan hozzáférhető Effect of Indoxyl Sulfate on Calcium Signaling in Gastrointestinal Smooth MusclesInam, Mubashra; Uray, Karen Lee; Általános Orvostudományi Kar::Orvosi Vegytani Intézet; DE--Általános Orvostudományi KarThe gut microbiome influences host physiology both by exerting local effects and through the absorption of bioactive metabolites into the blood circulation to reach distant organs, such as the small intestine. Indoxyl sulfate (IS), which is synthesized by gut microbiota during tryptophan metabolism, has been extensively studied in renal and cardiovascular disorders, but its role in intestinal motility is poorly defined. Therefore, we aimed to study the effect of IS on the contractile activity and calcium signaling in the small intestine. The ex vivo spontaneous and agonist-induced contractile activity in intestinal strips was measured after treatment with IS at the concentrations approximating blood circulating levels. In addition, changes in the calcium sensitivity of intestinal contractile activity were measured. To define the signaling pathway by which IS acts, pregnane X receptors (PXR) and aryl hydrocarbon receptors (AhcR) antagonists were tested during agonist-induced contractions. The IS-induced changes in intracellular calcium in the primary human intestinal smooth muscle cells (HISMCs) were measured using FURA 2-AM fluorescence assay. Our findings showed that IS significantly inhibited agonist-induced contractile activity compared with vehicle (DMSO) treatment. After calcium depletion, contractile activity increased significantly with increasing calcium concentrations in the vehicle-treated intestinal strips but not in the IS-treated intestinal strips, indicating that IS affected calcium sensitivity. Treatment with a PXR antagonist but not AhR antagonist blocked IS-induced inhibition of agonist-induced contractile activity. The fluorescence assay showed that IS increased intracellular calcium in a dose-dependent manner. These results demonstrate that IS inhibits agonist-induced intestinal motility via PXR receptors and potentially via altered influx/efflux of calcium. The disruption of calcium-dependent intestinal contractions by IS could affect gut motility and may affect nutrient absorption and gastrointestinal health.Tétel Korlátozottan hozzáférhető IMPACT OF LAMIN A ON PPARγ-DNA BINDINGSharma, Anshu Kumar; Vámosi, György; Sen , Pialy; Általános Orvostudományi Kar::Biofizikai és Sejtbiológiai Intézet; DE--Általános Orvostudományi KarThis study investigated how the absence of lamin A, a key nuclear structural protein, affects the mobility and DNA-binding of the lipid-regulating receptor PPARγ. Using viral transduction, researchers expressed EGFP-tagged PPARγ in both wild-type and lamin A-knockout mouse adult fibroblasts. Fluorescence correlation spectroscopy (FCS) identified two distinct PPARγ populations: a fast, freely diffusing group and a slow, DNA-bound group. Treating the cells with the ligand rosiglitazone (RSG) significantly increased the slow, DNA-bound population and decreased overall diffusion constants in both cell types. This treatment also revealed that PPARγ preferentially binds to euchromatin over heterochromatin regions. Ultimately, the data demonstrated that while RSG strongly promotes PPARγ DNA-binding, the absence of lamin A has no significant impact on this binding activity.Tétel Korlátozottan hozzáférhető An Atypical Antipsychotic Drug Enhances Thermogenic Capacity Of Human Cervical-Derived AdipocytesBosire, Emma Bosibori; Rini , Arianti; Általános Orvostudományi Kar::Biokémiai és Molekuláris Biológiai Intézet; DE--Általános Orvostudományi KarAdipose tissue brown/beige adipocytes express uncoupling protein 1 (UCP1) that enables them to dissipate energy as heat. Systematic activation of this process can alleviate obesity. Human brown adipose tissues are interspersed in distinct anatomical regions including deep cervical, paraspinal, and abdominal. Previous publications have reported that pharmacological compounds such as mirabegron and rosiglitazone can elevate the browning capacity of white adipocytes. Brexpiprazole is an atypical antipsychotic medication used for the treatment of major depressive disorder, schizophrenia, and agitation associated with dementia due to Alzheimer's disease. We aim to investigate the effect of long term brexpiprazole treatment on the thermogenic capacity of human subcutaneous (SC) and deep cervical (DC)-derived adipocytes.Tétel Korlátozottan hozzáférhető The role of oncometabolite-producing enzymes in R-loop regulationGigauri, Nata; Székvölgy, Lóránt; Gyógyszerésztudományi Kar; DE--Általános Orvostudományi KarThis Master's thesis explores the important relationship between cancer metabolism and genome stability. Specifically, the research investigates how the IDO1 enzyme influences the regulation of R-loops, which are unique DNA-RNA structures that can affect overall DNA stability. To test the hypothesis, laboratory experiments were conducted using two different breast cancer cell lines. These cells were analyzed using a combination of global R-loop detection and a specialized molecular technique called DRIP-qPCR. The findings provide new and meaningful insights into how IDO1-related metabolic pathways impact the genome. Overall, this study builds a solid foundation for future research aiming to better understand the underlying biology of cancer.Tétel Korlátozottan hozzáférhető SFPQ as a nuclear target of TIMAP-PP1c phosphatase complexAndrade Cedeño, Hugo Ernesto; Boratkó, Anita; Általános Orvostudományi Kar::Orvosi Vegytani Intézet; DE--Általános Orvostudományi KarSplicing factor proline- and glutamine-rich (SFPQ) is an essential RNA-binding protein (RBP) with diverse nuclear functions. In neurons, tight regulation of SFPQ is particularly important, as altered SFPQ function or mislocalization has been implicated in several neurodegenerative diseases. These alterations are often linked to changes in gene expression or in the phosphorylation state of SFPQ. TIMAP (TGF-beta-inhibited membrane-associated protein) is a regulatory subunit of protein phosphatase 1 (PP1). Our earlier work identified SFPQ as a nuclear interacting partner of TIMAP. Pathway enrichment analysis of transcriptomic changes following TIMAP depletion in SH-SY5Y cells revealed significant enrichment of processes associated with neuronal morphogenesis, projection development, and neuronal differentiation, all of which are biological functions in which SFPQ has well-established functions. SFPQ has reported phosphorylation sites at S8, S283, and T687, suggesting it may be regulated by the TIMAP-PP1c phosphatase complex. Our aim was to investigate whether the TIMAP-PP1c phosphatase complex regulates SFPQ through phosphorylation. Interaction between SFPQ and the TIMAP-PP1c complex was verified by pull-down assay, using recombinant PP1c and TIMAP proteins, and additionally, by immunoprecipitation of SFPQ from SH-SY5Y. Next, we have cloned the SFPQ coding sequence into pCMV-HA mammalian expression vector, and using site directed mutagenesis, T687A phosphonull and T687D phosphomimic mutants of SFPQ were created. TIMAP depleted (shTIMAP), and pLKO control (shCTRL) SH-SY5Y cells were transfected with wild-type and phosphomutant SFPQ encoding plasmids using Lipofectamine 3000 reagent. Western blot analysis in both cell lines confirmed the overexpression of all the recombinant proteins. Since the phosphorylation state of SFPQ can influence its subcellular localization, we performed immunofluorescent staining on transfected shCTRL and shTIMAP cells. Confocal microscopy revealed differences in the subcellular distribution of the SFPQ mutants, which will be further evaluated by cell fractionation. In conclusion, we validated that the TIMAP-PP1c phosphatase complex interacts with SFPQ and successfully created wild-type and T687 phosphomutants SFPQ clones, which can be used to explore the potential role of this complex in regulating SFPQ.Tétel Korlátozottan hozzáférhető Alternative Splicing in Recombinant Protein-Producing Chinese Hamster Ovary Cell LinesAdvincula, Ernest Gabriel C.; Marton-Dávid, Bernadett; Scholtz, Beáta; Általános Orvostudományi Kar::Biokémiai és Molekuláris Biológiai Intézet; DE--Általános Orvostudományi Kar; Kónya, Zoltán; Általános Orvostudományi Kar::Orvosi Vegytani IntézetThis thesis investigates the dynamics of alternative splicing (AS) in Chinese Hamster Ovary (CHO) cells, which are the industry standard for recombinant protein production. During the transition to the stationary growth phase, these cells experience high endoplasmic reticulum (ER) stress, yet the specific splicing changes that occur during this window have remained largely unexplored. To address this, the study utilized RNA sequencing (RNA-seq) combined with a rigorous bioinformatics pipeline to identify and validate significant AS events driven by culture progression. The analysis successfully isolated 28 alternatively spliced protein-coding genes with valid structural and functional predictions. These findings reveal a coordinated cellular survival strategy where cells reprogram their post-transcriptional and epigenetic machinery to endure nutrient deprivation and stress. Ultimately, this research highlights how AS shapes the adaptive ER stress response, providing valuable new molecular targets for future cell line engineering and proactive bioreactor monitoring.Tétel Korlátozottan hozzáférhető The Effect of Alpha-Ketoglutarate on High Phosphate-Induced Calcification of Vascular Smooth Muscle CellsMusaj, Zylkë; Jeney, Viktória; Csiki-Tóth, Andrea; Általános Orvostudományi Kar::Molekuláris Medicina Kutató Központ; DE--Általános Orvostudományi KarThis thesis investigated whether alpha-ketoglutarate (α-KG) can prevent vascular calcification, a harmful process in which calcium deposits accumulate in blood vessel walls, especially in chronic kidney disease and diabetes. The study used human vascular smooth muscle cells and mouse aortic tissue exposed to high phosphate levels, which normally trigger calcification. Results showed that α-KG significantly reduced calcium deposition, with higher concentrations almost completely preventing calcification in cultured cells. α-KG also decreased the expression of osteogenic markers (Runx2 and Sox9) while restoring the contractile marker SM22α, indicating that it prevented smooth muscle cells from transforming into bone-like cells. In mouse aortic rings, α-KG reduced phosphate-induced calcification by about 40%, confirming its protective effect in intact vascular tissue. Overall, the findings suggest that α-KG is a promising metabolic compound that may help prevent vascular calcification, although further studies are needed to clarify its exact mechanisms and therapeutic potential.Tétel Korlátozottan hozzáférhető Identification of transglutaminase 2 substrates in HUVEC cellsAhmad, Reem; Király, Róbert; Általános Orvostudományi Kar::Biokémiai és Molekuláris Biológiai Intézet; DE--Általános Orvostudományi KarThis thesis investigates the identification of Transglutaminase 2 (TG2) substrate proteins in human umbilical vein endothelial cells (HUVECs). Using biotin-based substrate labeling, affinity purification, and LC-MS/MS analysis, the study aimed to identify both glutamine-donor and lysine-donor TG2 substrates. Eight glutamine-donor substrate proteins were successfully identified, including proteins involved in glycolysis, cytoskeletal organization, and cellular structure. Comparison with existing databases confirmed most of these proteins as known TG2 substrates, while pyruvate kinase (PKM) emerged as a potential novel substrate in HUVEC cells. In parallel, lysine-donor substrate labeling and enrichment were successfully established, providing the basis for ongoing mass spectrometry analysis. The findings contribute to a better understanding of TG2 function in endothelial biology and its potential relevance in cardiovascular disease, cancer, and angiogenesis-related processes.Tétel Korlátozottan hozzáférhető SUBLINEAGE-SPECIFIC A45S POLYMORPHISM ALTERS THE BIOLOGICAL FUNCTION OF THE HUMAN PAPILLOMAVIRUS 11 E7 ONCOPROTEINDagane, Abdinoor; Szalmás, Anita; Általános Orvostudományi Kar::Orvosi Mikrobiológiai Intézet; DE--Általános Orvostudományi KarThis thesis investigates how a naturally occurring A45S amino acid substitution in the HPV11 E7 oncoprotein affects its biological function and potential role in disease progression. The study found that the HPV11 A2 (S45) variant more effectively degrades pRb family proteins, leading to enhanced activation of E2F-regulated genes compared to the prototype HPV11 A1 variant. Increased expression of DNA repair genes, including BRCA1, BRCA2, RAD51, and ATM, was observed in keratinocytes expressing the S45 variant, suggesting stronger modulation of host cellular pathways. Additionally, cells expressing HPV11 S45 E7 exhibited reduced cytotoxicity and improved viability, indicating a greater capacity to support viral persistence. Overall, the findings suggest that the A45S polymorphism gives HPV11 E7 high-risk-like molecular properties that may contribute to the aggressiveness and persistence of HPV11-associated diseases such as recurrent respiratory papillomatosis.Tétel Korlátozottan hozzáférhető Transcriptomics analysis of IDO-1 overexpressing breast cancerMehqemeja, Iris; Székvölgyi, Lóránt; Ráduly , Zsolt; Gyógyszerésztudományi Kar; DE--Általános Orvostudományi KarThis thesis investigates the impact of IDO1 overexpression on gene expression in triple-negative breast cancer cells using RNA sequencing and RT-qPCR validation. The study addresses an important aspect of cancer biology by exploring the role of IDO1 beyond its established function in immune suppression. The methodology is appropriate and combines high-throughput transcriptomic analysis with experimental validation of selected genes. The results demonstrate that IDO1 influences multiple cellular processes, including transcription, RNA processing, DNA repair, and metabolic regulation, highlighting its broad contribution to tumor progression. The findings provide valuable insights into the molecular mechanisms underlying breast cancer development and may support the identification of novel therapeutic targets. Overall, this work represents a well-designed and relevant contribution to understanding the role of IDO1 in triple-negative breast cancer.Tétel Korlátozottan hozzáférhető EXPLORING THE ROLE OF THE PROTEASOME ACTIVATOR PA200 IN DECREASED FERTILITY OF HD TRANSGENIC MALE MICEŞaşo, İlayda Eylül; Tar, Krisztina; Általános Orvostudományi Kar::Orvosi Vegytani Intézet; DE--Általános Orvostudományi KarThis thesis investigates the molecular mechanisms of reduced male fertility in a transgenic mouse model of Huntington’s disease (HD). The study focuses on the role of the proteasome activator PA200, which is important for normal spermatogenesis and protein degradation processes in the testes. HD and wild-type mice testes were investigated at the histological and molecular level. The results show testicular development impairment, impaired spermatogenesis, and alterations in gene expression in HD mice. These findings suggest that PA200-related proteasome activity may contribute to fertility problems in HD male mice.Tétel Korlátozottan hozzáférhető Obtaining correlation between echocardiography and cardiac computed tomography measurements in severe aortic stenosis patientsUgbodaga, Christabel Omoaregha; Kolozsvári, Rudolf; Általános Orvostudományi Kar::Kardiológiai Intézet; DE--Általános Orvostudományi KarBackground: as the human body advances with age, all organs go through different aging mechanisms. The aortic valve is under continuous pressure change from the moment the embryo has heartbeat. With age, calcification, fibrotic changes and degeneration take place in the leaflets and the fibrotic annule of the valve, concluding in severe aortic stenosis (AS), and often in aortic regurgitation (AR). Severe AS provides resistance of the blood flow from the left ventricle to the body, causing global ischemia. With echocardiography, it is possible to measure the extent of the degeneration. With cardiac-CT (CCT), morphological parameters and contrast densities in different territories can be evaluated. Aims/methods: 57 patients were enrolled in the study all with severe AS during pre-TAVI evaluation. With echocardiography, peak and mean transvalvular gradients and velocity, along with valve opening area during systole were measured. With CCT, contrast densities (HU) were measured in the left ventricular outflow tract (LVOT), in the non-coronary cusp (NCC), left coronary cusp (LCC); right coronary cusp (RCC), at the Sino-tubular junction (STJ) and 4cm from the STJ (4STJ). Correlation between any of these parameters were to be investigated. Results: with regards to the densities in the selected territories, significant correlation was only found between the aortic valve area and all HU measurements: LVOT R=-0,288, p=0,030; RCC R=-0,334, p=0,011; NCC R=-0,34, p=0,009; LCC R=-0,372, p=0,004; R=-0,312, p=0,018, and 4STJ R=-0,291, p=0,028. When looking for correlation between gradients and velocity, no significant results were found. Conclusion: significant correlation was only found when comparing the valve area parameters measured by echocardiography with any of the densities- thus, certain CCT values can predict the valve area progress. More sophisticated measurement methods need to be used to find out why only the area provided good correlation.Tétel Korlátozottan hozzáférhető Dexmedetomidine in Anaesthesia: Pharmacological Mechanisms and Expanding Clinical rolesAbdelrazek, Tasnim Nasreldin; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetAnesthetic practice has traditionally relied on GABAergic agents, which induce deep unconsciousness but often impair breathing and delay cognitive recovery. Dexmedetomidine offers an alternative by targeting alpha-2 adrenergic receptors in the Locus Coeruleus, producing a biomimetic, sleep-like state that preserves cooperation and reduces the need for opioids and volatile anesthetics, thereby lowering postoperative nausea and delirium. Recent research highlights its organ-protective effects, showing it can shield the brain, heart, and kidneys from ischemia-reperfusion injury through molecular mechanisms such as regulating autophagy and inhibiting the NLRP3 inflammasome. However, its sympatholytic action can cause bradycardia and hypotension, so its use is best tailored to high-risk cases where organ protection outweighs cardiovascular risks.Tétel Korlátozottan hozzáférhető SGLT2 Inhibitors in Diabetes Management: Cardioprotective and Renoprotective BenefitsTaimova, Shynar; Pórszász , Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, A. József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis examines how sodium–glucose cotransporter-2 (SGLT2) inhibitors have evolved from purely glucose-lowering drugs into agents with important cardiovascular and renal benefits. It outlines the main biological mechanisms underlying these effects, such as changes in renal hemodynamics, energy metabolism, and inflammatory pathways. The work reviews evidence from large clinical trials showing reduced rates of heart failure hospitalization and slower progression of chronic kidney disease. Special attention is given to the clinical impact of these findings in both diabetic and non-diabetic populations. In conclusion, the thesis highlights the growing importance of SGLT2 inhibitors in contemporary cardio-renal-metabolic therapy.Tétel Korlátozottan hozzáférhető Peripheral atherosclerosis and coagulation dynamics in carotid stenosisAyman Yahya, Dinay; Szegedi , István; Lóczi, Linda; Általános Orvostudományi Kar::Neurológiai Tanszék; Általános Orvostudományi Kar::Laboratóriumi Medicina Intézet; DE--Általános Orvostudományi KarCarotid atherosclerosis is a major cause of ischemic stroke, influenced by risk factors such as hypertension, hyperlipidemia, smoking, diabetes, and obesity, which promote vascular dysfunction and plaque progression. While platelet function and atherosclerosis have been extensively studied, the link between atherosclerosis extent and coagulation activation remains unclear. Aim: To investigate the association between carotid stenosis, peripheral atherosclerosis, and hypercoagulability, as assessed by the thrombin generation assay. Methods: In this pilot study, 30 patients from the Department of Neurology without acute thrombotic disease were enrolled. Carotid stenosis was evaluated by Doppler ultrasonography and classified as mild (1–49%) or advanced (50–100%). Peripheral atherosclerosis was assessed using the ankle-brachial index (ABI). Thrombin generation was measured in platelet-free plasma. Demographics, comorbidities, and medication use were recorded. Results: No significant association was found between thrombin generation parameters and carotid stenosis severity. However, patients with advanced stenosis had significantly lower ABI values than those with mild stenosis (left ABI: 1.09 ± 0.18 vs. 0.94 ± 0.19, p = 0.039; right ABI: 1.11 ± 0.17 vs. 0.86 ± 0.19, p = 0.001), suggesting greater systemic atherosclerotic burden. In the mild stenosis group, triglyceride levels inversely correlated with CRP (r = −0.5581, p = 0.0328). Across the entire cohort, peak thrombin and endogenous thrombin potential (ETP) positively correlated with CRP (r = 0.3802, p = 0.0382; r = 0.3753, p = 0.0410). Time to peak also correlated with triglycerides in both the advanced stenosis group (r = 0.653, p = 0.008) and the full cohort (r = 0.501, p = 0.005). Conclusion: These findings suggest that localized carotid atherosclerosis is not directly linked to systemic thrombin generation. Conversely, ABI, reflecting systemic atherosclerotic burden, was significantly associated with advanced carotid stenosis, highlighting its value as a complementary diagnostic tool. The observed correlations indicate a complex interplay among lipid metabolism, inflammation, and coagulation in patients with atherosclerosis.Tétel Korlátozottan hozzáférhető New frontiers innlipid managment: The role of inclisiran in cardiovascular risk reductionEl Hassan, Omar; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet-ASCVD Pathogenesis: Atherosclerotic Cardiovascular Disease remains the leading global cause of death, progressing from initial lipid retention and inflammation to the development of vulnerable plaques susceptible to life-threatening rupture. -Diagnostic Evolution: Beyond basic lipid profiles, modern 2026 clinical assessments now integrate high-sensitivity C-reactive protein (hsCRP), calcium scoring, and ankle-brachial index (ABI) to provide a more comprehensive view of vascular health. -Addressing the Adherence Gap: While traditional statins and ezetimibe are effective, the chronic "adherence gap" of daily oral medications has historically limited the success of long-term risk reduction. -The siRNA Frontier: Inclisiran has revolutionized therapy by utilizing a GalNAc delivery system to enter hepatocytes and leverage the RNA-induced silencing complex (RISC) to stop PCSK9 production at the genetic level. -Clinical Validation: Extensively validated by the ORION trial program, this siRNA therapy provides stable and durable LDL-C reduction through a convenient biannual dosing schedule administered by healthcare providersTétel Korlátozottan hozzáférhető New perspective of antidepressant and antianxiety pharmacological developmentFarkash Lange, Sheli; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis Thesis focuses on the new aspect of pharmacological development for anxiety and depression. It compares traditional drugs for treatment with the old ones. It looks at how can we treat people who have side effect or the existing drugs.Tétel Korlátozottan hozzáférhető Drug Interactions in Cardio-OncologyHassan, Sara Khaled Abdelaal Hassan; Megyeri, Attila; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetAccording to statistics from the Global Burden of Disease (GBD) compare platform, cardiovascular diseases (CVDs) and cancers were the leading causes of patient morbidity and mortality worldwide between 2016 and 2019, measured in Disability Adjusted Life Years (DALYs). Both of these conditions can co-exist in a single patient and are linked to risk factors, such as dyslipidemia and hypertension (HTN). The simultaneous affliction of patients with both conditions mandates the co-administration of cardiac and oncologic drugs, which in turn leads to drug-drug interactions (DDIs), either pharmacodynamic (PD) or pharmacokinetic (PK). These DDIs, as a side effect, promote the development of more risk factors within these patients. In this thesis, I establish and highlight a potential causative link between these DDIs and the increased DALYs associated with CVDs and cancer, demonstrating several examples of combinative regimens that induce specific risk factors, such as HTN. Based on the information reviewed in this paper, the high DALYs in cardio-oncology patients may be partly iatrogenic, caused by DDIs, and further research is mandated to explore better combinative regimens with fewer adverse effects.