Theses (Faculty of Medicine)
Állandó link (URI) ehhez a gyűjteményhez
Böngészés
legfrissebb feltöltések
Megjelenítve 1 - 20 (Összesen 1621)
Tétel Korlátozottan hozzáférhető New Treatments in IBDElshenawy, Omar Ahmed Mohamed; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi , József; Halasi, Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetIBD significantly impacts millions of people, severely reducing their quality of life due to the incapacitating nature of symptoms. Recent advancements in IBD treatment emphasize targeted therapies that more accurately address the underlying mechanisms of the disease. The shift towards personalized medicine represents a novel approach, using genetic, microbiome, and pharmacogenomic information to tailor treatments, enhance effectiveness, minimize side effects, and improve overall healthcare outcomes.Tétel Korlátozottan hozzáférhető Pharmacological Therapy Of Gastrointestinal Neoplastic DiseasesNasrallah, Fady Mourad Saad Kamel; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThe current treatments of gastrointestinal cancers vary based on the exact cancer type and stage. It includes chemotherapy, radiotherapy , immune therapy and finally, surgical interventions.Tétel Korlátozottan hozzáférhető Gastrointestinal BleedingAdewuyi, Joshua Adeyemi; Altorjay, István; Általános Orvostudományi Kar::Belgyógyászati Intézet::Gastroenterológiai Tanszék; DE--Általános Orvostudományi Kar; Várvölgyi, Csaba; Csiki, Zoltán; Általános Orvostudományi Kar::Belgyógyászati Intézet::Gastroenterológiai Tanszék; Általános Orvostudományi Kar::Belgyógyászati IntézetThis review aims to discuss as well as summarize the currently available information on gastrointestinal bleeding (GIB). The various types, categories, etiology, diagnosis, and managements of GI bleeding will be discussed. Gastrointestinal bleeding is a medical condition frequently encountered in clinical practice. Overt gastrointestinal bleeding usually presents as melena or hematemesis but can also present as hematochezia in cases of brisk bleeding ...Tétel Korlátozottan hozzáférhető Pharmacology of Neurogenic InflammationLiu, Siou; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dóra; Szentmiklósi, József; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThe thesis is about the pharmacology of neurogenic inflammation. Neurogenic inflammation is a process in which neuropeptide-releasing sensory nerves participate in the inflammatory process. By activating the sensory nerve fibers, it triggers the release of the neuropeptides leading to various vascular and non-vascular change. Neurogenic inflammation can be involve in several conditions including asthma and migraine, so recognition and further investigation their therapeutic use become extremely importance. In the thesis, we will summarized the possible molecules which can be or had been investigated as the potential therapeutic targets and the application in some diseases.Tétel Korlátozottan hozzáférhető Recent Advancements in the Pharmacological Treatment of Ovarian CancerKunlere, Opeoluwa Mary; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara; Szentmiklósi, József; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis thesis explores recent advancements in the treatment of ovarian cancer, highlighting both existing and emerging therapeutic strategies. It reviews the role of approved treatments like PARP inhibitors and bevacizumab, while also discussing promising new approaches such as immunotherapy, endocrine therapy, and nanoparticle-based drug delivery systems. Additionally, it investigates the potential of gene therapy to target cancer at the molecular level, focusing on overcoming drug resistance and enhancing patient outcomes. The work emphasizes the need for personalized medicine, where treatment is tailored based on the genetic profile of the cancer. Overall, the thesis underscores the importance of continued research into combining therapies to improve survival rates and reduce side effects for ovarian cancer patients.Tétel Korlátozottan hozzáférhető BACH1 and Its Role in Modulating the Inflammatory Response of MacrophagesHussein, Mohamed Osama Kamalaldin; Nagy, László; Bene, Krisztián; Általános Orvostudományi Kar::Biokémiai és Molekuláris Biológiai Intézet; DE--Általános Orvostudományi KarThe study investigated the role of BACH1 in regulating inflammatory responses in macrophages (MFs). BACH1 was found to bind genomic regions with key MF transcription factors, suggesting it influences genes related to pattern-recognition receptor (PRR) signaling pathways. Using bone marrow-derived macrophages (BMDM) from Bach1 knock-out (KO) and control mice, We confirmed Bach1 deletion via Western blot and assessed transcriptional changes. We observed increased expression of genes related to inflammation, such as Il1b, Il6, and Il10, in a BACH1-dependent manner, particularly following LPS treatment. The KO cells also showed heightened levels of HMOX1 protein and altered cytokine production, including IL-6, measured by ELISA. The absence of BACH1 affected inflammatory responses in both alveolar and peritoneal macrophages, supporting the idea that BACH1 modulates inflammation across diverse MF types and activation states.Tétel Korlátozottan hozzáférhető Overview of the epithelial carcinoma of the ovariesOjinika, Assumpta chidera; Takács, Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Priksz, Dániel; Berindán, Krisztina; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Szülészeti és Nőgyógyászati IntézetThis thesis talks about the overview of epithelial carcinoma an in it is discusses the etiology , risk factors , symptoms and diagnostic methods and staging of ovarian cancer. its also talks about the chemotherapy strategies and the medications which can be used for its treatment. It contains the drug mechanism of actions , doses, side effects and some clinical trials.Tétel Korlátozottan hozzáférhető Prevention And Pharmacological Management Of ArrythmiaAhmad, Mostafa; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dora; Szentmiklósi, József; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis paper discusses arrhythmias and their myriad of causes. Topics such as incidence and prevalence in the population are also discussed. Global patterns and future trends are mentioned in regards to arrhythmia. The treatment for arrhythmia whether it be conservative or pharmacological is also mentioned. The different types of medication is distinguished in the discussion of the topic.Tétel Korlátozottan hozzáférhető Improvement in Quality of Care for Patients with Type 2 Diabetes in Hungary Between 2009 and 2019.Babalola, Elijah Oluwatobi; Sándor, János; Egészségtudományi Kar; DE--Általános Orvostudományi KarIn this research essay, the topic of diabetes, its treatment modalities, and its effectiveness in Hungary over the last decade will be explored in detail. It will examine the trends in diabetes prevalence in Hungary, the challenges faced in managing the disease, and the impact of various treatment approaches on patient outcomes. Analyzing the successes and areas for improvement in Hungary's diabetes care system. The essay will explore the impact of socioeconomic factors on diabetes outcomes in Hungary. The essay will examine the advancements in diabetes research and technology that have influenced diabetes care in Hungary.Tétel Korlátozottan hozzáférhető Pharmacological Management of Neurodegenerative diseasesMorvaridian, Nikta; Pórszász , Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Atila; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetGlobally, communities are burdened with significant medical and public health costs due to degenerative illnesses of the neurological system. The three main neurodegenerative disorders are amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), Huntington’s disease (HD), and Alzheimer's disease (AD). Since these illnesses are more common and more severe as people age, more instances are anticipated in the near future as life expectancy continues to climb in many nations. With few exceptions, the relative contributions of genetic and environmental variables to causation remain poorly understood. However, molecular epidemiology methods have shown promise in enhancing disease diagnosis, defining disease prognostic factors, pinpointing genes at high risk for familial neurodegenerative diseases, examining shared genetic variants that could indicate susceptibility to the non-familial forms of these illnesses, and measuring exposure to the environment. The epidemiologic characteristics of PD, AD, HD, and ALS are introduced in this literature, along with the pathophysiology of the underlying disease processes and risk factors that may eventually result in better medical therapy and disease prevention. A few suggestions for the pharmaceutical and non-pharmacological treatment of NDs are included in the chapter's conclusion.Tétel Korlátozottan hozzáférhető Correlation Between Implantation Depth and Permanent Pacemaker Implantation Rate in Patients Having Transcatheter Aortic Valve Implantation at The Institute of Cardiology in The University of DebrecenAnyigbo , Mediatrix; Kracskó, Bertalan; Általános Orvostudományi Kar::Kardiológiai Intézet::Kardiológiai Tanszék; DE--Általános Orvostudományi Kar; Bianka; Általános Orvostudományi KarStudies have shown a positive correlation between the final position of implanted aortic valve and the need for permanent pacemaker insertion following TAVI resulted in increased long-term mortality in this subset. The new cusp overlap technique is supposed to increase the chance for appropriate valve implantation in the native aortic annulus reducing permanent pacemaker rate. Cusp overlap technique significantly influenced the implantation depth resulting in higher implantation, while lower implantation depth resulted in a significantly higher amount of permanent PM implantation.Tétel Korlátozottan hozzáférhető Smoothelin-Like Protein 1 Regulates The Thyroid Hormone-Induced Remodeling of C2C12 CellsNahas, Ammar; Lontay, Beáta; Általános Orvostudományi Kar::Orvosi Vegytani Intézet; DE--Általános Orvostudományi Kar; Miklós; Általános Orvostudományi KarSkeletal muscle fatigue is a symptom of hyperthyroidic patients. The exact mechanism was not understood but smoothelin-like protein 1 (SMTNL1) was suspected to be the cause. Therefore, in this experiment, we investigated the effect of hyperthyroidism and overexpression of SMTNL1 protein on the C2C12 mouse myoblast cell line. To accomplish overexpression, we transfected the myoblasts with SMTNL1. We then studied the effect of hyperthyroidism by growing the transfected myoblasts under hyperthyroid conditions and comparing it to the control in a scratch assay to see the effect it would have on myoblast migration. We specifically wanted to check the effect of hyperthyroidism and SMTNL1 overexpression on the levels of phosphorylated and unphosphorylated MLC20 and MYPT1. We noticed that SMTNL1 overexpression and hyperthyroidism impeded cell migration in the scratch assay, SMTNL1 overexpression and hyperthyroidism have also increased phosphorylation of MYPT1. MYPT1 is deactivated when it’s phosphorylated and hence cannot dephosphorylate MLC20.Tétel Korlátozottan hozzáférhető Pharmacological Management of COPDSuresh, Dervin; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Barbara, Halasi; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetChronic Obstructive Pulmonary Disease (COPD) is a lung disease whose hallmark features include anomalies in alveolar gas exchange and airflow restriction that cause persistent respiratory symptoms.Dyspnea, productive cough, and, in later stages, tachypnea, tachycardia, and cyanosis are among the clinical symptoms. Pulmonary Function Tests (PFTs), which usually demonstrate a reduced ratio of Forced Expiratory Volume (FEV) to Forced Vital Capacity (FVC), are the main diagnostic tools. The clinical presentation is also used to make the diagnosis. Imaging investigations are useful in determining the degree of potential consequences and the severity of the disease. Both short- and long-acting bronchodilators are another major form of treatment. Long-acting medications are given on a daily regimen, while short-acting medications are used as rescue medications. Novel medications such as stem cell therapy and monoclonal antibodies are currently under investigation and are showing promising results.Tétel Korlátozottan hozzáférhető EFFECTS OF DIFFERENT TYPES OF ARTERIO-VENOUS FISTULAS ON CIRCULATIONFiebai , Owen; Fazekas, László; Németh, Norbert; Általános Orvostudományi Kar::Sebészeti Műtéttani Tanszék; DE--Általános Orvostudományi Kar; Tamás; Általános Orvostudományi KarThis study investigated the impact of arterio-venous shunts on blood parameters in a rat model of heart failure. Researchers divided 28 rats into three groups, including a control group, an aorto-caval group (AC) with a side-to-side aorto-caval anastomosis, and a femoral arterio-venous (FAV) group with a femoral vein-to-artery connection. Blood tests showed an early increase in white blood cell and platelet counts across groups, with red blood cell counts initially dropping then rising. Notably, red blood cell deformability worsened, particularly in the AC and FAV groups, alongside increased red blood cell aggregation, especially in the FAV group. These results suggest that arterio-venous shunts can worsen blood flow and contribute to heart failure pathophysiology through hematological and micro-rheological changes.Tétel Korlátozottan hozzáférhető Pharmacological Aspect of Indonesian Herbal Medicine in the Treatment of PreeclampsiaMizuno, Ayuna; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dóra; Szentmiklósi, József; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetPreeclampsia, a hypertensive disorder of pregnancy, poses significant global health challenges, particularly in developing countries like Indonesia, where it contributes to high maternal and neonatal morbidity and mortality rates. The disorder is marked by hypertension, proteinuria, and multi-organ dysfunction, arising from complex pathophysiological mechanisms including abnormal placentation, immune dysregulation, oxidative stress, and endothelial dysfunction. Conventional treatments focus on managing symptoms and preventing severe complications, but alternative therapies, such as herbal medicine, offer potential complementary approaches, particularly in resource-limited settings. This article explores the therapeutic potential of five herbal medicinal plants—Curcuma longa (turmeric), Apium graveolens (celery), Punica granatum (pomegranate), Glycine max (soybeans), and Cocos nucifera (coconut)—commonly used in Indonesian traditional medicine. These plants possess bioactive compounds with anti- inflammatory, antioxidant, antihypertensive, and anti-cancer properties, which may contribute to the management and prevention of preeclampsia. The integration of these herbal remedies into treatment protocols could optimize preeclampsia management, particularly in settings where conventional pharmaceutical options are limited. However, while these herbs show promise, the article emphasizes the need for further clinical research to validate their efficacy and safety, particularly concerning their bioavailability, potential side effects, and interactions with conventional medications.Tétel Korlátozottan hozzáférhető Pharmacological tools in the endometrial cancer treatmentMojo-Eyes, Kamsiyonna Alexander; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara; Megyeri, Attila; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetPharmacotherapy of Endometrial cancer and new regimensTétel Korlátozottan hozzáférhető Methods in the Management of Postoperative PainObodozie, Maria-Regina Udochi; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Drimba, László; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Klinikai Központ::Kenézy Gyula CampusPostoperative pain, though predictable and expected by patients before surgery can have adverse and even debilitating effects on the quality of life of the patient. Considering the ongoing opioid crisis experienced countries around the world and the fact that a number of the sufferers are postsurgical patients struggling due to poor postsurgical pain management, there is need to look into other pain management options available. Multi-modal and inter-disciplinary options will optimize results, empower patients with options, prevent chronic postsurgical pain and manage pain if it becomes chronic. Patient education and proper consideration of the postsurgical social realities of the patient while planning the postsurgical pain management would have a better outcome with postsurgical pain management. Understanding the available postsurgical treatments, pharmaceutical and non-pharmaceutical, shines light to the need for more advancement in postoperative care especially regarding pain, and the need for proper outpatient care of the postsurgical patient.Tétel Korlátozottan hozzáférhető Opioid analgesics use in everyday surgical practiceYousefi , Mahsa; Pórszász , Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Drimba , László; Megyeri, Attila; Általános Orvostudományi Kar::Aneszteziológiai és Intenzív Terápiás Tanszék; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetOpioids are a vital component in managing pain for surgical patients. However, they also pose a problem due to their addiction and potential for abuse. In this paper, I will discuss the rationale for opioid use, and its significant acute adverse effects, as well as complications contributing to their long-term use such as opioid-induced tolerance, and addiction. First, their mechanism of action, structures, method of use, and some terminology will be discussed. Understanding their mechanism of action on receptors helps us grasp a better understanding of their usage, and management of side effects. Next, we will compare the efficacy of the most widely used opioids along with antagonists for treating acute and chronic misuse of opioids. Finally, I will briefly go into multimodal analgesia strategies designed to lessen the use of opioids.Tétel Korlátozottan hozzáférhető Pharmacology of management of comaHUNG, HSIN-YUAN; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara; Szentmiklósi, József; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetComa represents an extended period of unconsciousness where individuals cannot be roused and are unresponsive to stimuli such as pain, light, or sound. They lack a typical sleep-wake cycle. The management of coma, across its various types, stands as a significant concern within contemporary medical practice. Treating this condition presents a formidable challenge for specialists in intensive care units and other medical professionals. The author's selection of this prevalent and compelling issue is noteworthy.Tétel Korlátozottan hozzáférhető Management of deliriumSaharkhiz, Zahra; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Drimba, László; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Aneszteziológiai és Intenzív Terápiás TanszékDelirium is the most prevalent yet unfortunately the most neglected neuropsychiatric syndrome. This syndrome is preventable but difficult to treat and potentially leads to irreversible complications. In this article required information for primary caregivers are included