Theses (Faculty of Medicine)
Állandó link (URI) ehhez a gyűjteményhez
Theses collection of the Faculty of Medicine. The collection was started in 2014.
At the University of Debrecen, in accordance with the 2022 amendment to the 2011 Higher Education Act, student theses are only accessible from devices connected to the University's Eduroam WiFi network or from a university IP address.
“The thesis or diploma work of a student who has successfully passed the final examination shall be stored in full in the academic system of the higher education institution, and a record shall be maintained thereof. The stored theses and diploma works – with the exception of parts classified as confidential in accordance with the relevant legislation – must be made accessible and searchable without restriction through the academic system.” Further info on the National Higher Education Act in Hungarian: Felsőokt. tv. (új) - 2011. évi CCIV. törvény a nemzeti felsőoktatásról - Hatályos Jogszabályok Gyűjteménye.
Böngészés
legfrissebb feltöltések
Megjelenítve 1 - 20 (Összesen 1884)
Tétel Korlátozottan hozzáférhető Comparing the efficacy of ACE Inhibitors and ARBs in treatment of the hypertensionChoi, Jae Young; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetHypertension is a huge health concern around the world and a main reason why people get heart and kidney illnesses. This research looks at how well ACE inhibitors and ARBs work for high blood pressure, by going over what’s been shown in clinical trials, comparing how they stack up against each other, and looking at the results of multiple analyses. Both of these kinds of drugs bring blood pressure down by interfering with the renin-angiotensin-aldosterone system, but they do so in slightly different ways. When doctors have actually used them, ACE inhibitors and ARBs have been found to lower blood pressure by about the same amount, and crucially, lower the chance of heart problems. Plus, both types of medication are good for your kidneys, especially for those with diabetes or long-term kidney disease. On the whole, ACE inhibitors have lots of proof of reducing deaths from heart issues, however ARBs are often equally effective and are easier for people to keep taking, so both are valuable for managing hypertension.Tétel Korlátozottan hozzáférhető Anticoagulation after ischemic stroke: start, restart, or replace — when and what?Ansari, Zoya Surayya Andaleeb; Csiba, László; Általános Orvostudományi Kar::Neurológiai Tanszék; DE--Általános Orvostudományi Kar; Fekete, Klara; Barta, Judit; Általános Orvostudományi Kar::Neurológiai Tanszék; Általános Orvostudományi Kar::Kardiológiai IntézetStroke is the leading cause of acquired disability in adults worldwide, and preventing the recurrence of stroke is a long-standing question in the field of neurology. For cardiogenic stroke, anticoagulation therapy is the most important method of preventing recurrence. We aimed to investigate the similarities and differences between the international guidelines as for the anticoagulation therapy of cardiogenic stroke. These included the America, Canadian, British/Irish and European guidelines. We classified the guidelines by the cardiogenic event and if there was previous therapy.Tétel Korlátozottan hozzáférhető Investigation of testicular ischemia-reperfusion injury in an experimental modelAbdulrahman A.H., Ahmad; Németh, Norbert; Domján, István; Általános Orvostudományi Kar::Sebészeti Műtéttani Tanszék; DE--Általános Orvostudományi Kar; Lesznyák; Általános Orvostudományi KarThis research created a model using rats to look at the changes in blood flow, tiny blood vessels, and tissue damage after a testicle is twisted for one hour. Using a special kind of ultrasound, it was found that blood flow stopped completely when the testicle was twisted and didn't go back to normal even after it was untwisted. The tiny blood vessels in the testicle and the tube that stores sperm were still not working properly a week after the injury. When the tissues were looked at under a microscope, there was a lot of damage, including the tubes that make sperm shrinking and a big decrease in the production of sperm. The study shows that when a testicle is twisted and then untwisted, it can cause damage to the tissue and affect the whole body's blood flow.Tétel Korlátozottan hozzáférhető The Impact of Volatile vs. Intravenous Anesthesia on Postoperative Cognitive DysfunctionSuwabe, Nagi; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis reviews whether volatile anesthesia and propofol-based total intravenous anesthesia differ in their effects on postoperative cognitive dysfunction in elderly patients. Some studies suggest that propofol-based anesthesia may reduce early cognitive decline in selected non-cardiac surgical settings, but results remain inconsistent across different patient populations and procedures. The findings indicate that anesthetic depth, neurophysiologic suppression, and perioperative management may influence postoperative cognitive outcomes more strongly than anesthetic agent alone. Postoperative cognitive dysfunction appears to be multifactorial and influenced by both patient-related and perioperative factors. Overall, anesthetic choice should be considered within a broader perioperative strategy for protecting cognitive function in elderly patients.Tétel Korlátozottan hozzáférhető Use of Histone Deacetylase inhibitors (HDI): Novel advances in cancer treatmentAl Nasser, Mohammad; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetIn conclusion, via regulating gene expression and chromatin structure, HDACs are essential for epigenetic regulation. Their dysregulation is closely linked to the onset and spread of cancer, mainly by enhancing oncogenic pathways and suppressing tumor suppressor genes. These epigenetic changes can be reversed by HDI, which have become useful therapeutic treatments. HDI stimulate the reactivation of genes, trigger apoptosis, arrest the cell cycle, and disrupt several cellular functions needed for tumor survival by increasing histone acetylation. Their anticancer potential is further enhanced by their additional effects on the tumor microenvironment. The clinical uses of HDI in hematological malignancies have shown significant therapeutic benefits even in cases that are resistant to treatment. Combination therapies have shown positive outcomes as well. However, related side effects still exist. In the end, HDI offer a novel method of focusing on the fundamental process of tumor growth, representing a significant progress in the field of epigenetic cancer treatment.Tétel Korlátozottan hozzáférhető Pharmacological Aspects of General AnesthesiaSfaxi, Salma; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetGeneral anesthesia relies on a combination of drugs to achieve hypnosis, analgesia, and immobility during surgery. Key agents such as propofol, sevoflurane, fentanyl, and neuromuscular blockers act through distinct mechanisms, including GABA-A receptor modulation and inhibition of pain pathways via μ-opioid receptors. Muscle relaxants further contribute by interfering with acetylcholine at the neuromuscular junction. The pharmacokinetics of these drugs determine their onset, duration, and recovery profile, while pharmacodynamics influence their clinical effects and potential adverse reactions. Patient-specific factors, such as age, obesity, and comorbidities, play a crucial role in drug selection and dosing. A thorough understanding of these pharmacological principles is essential for safe and effective perioperative management.Tétel Korlátozottan hozzáférhető pharmacological management of common pediatric ophthalmological diseases: myopia, amblyopia, glaucoma, and retinopathy of prematurity.shadpour, shakiba; Varga, Balázs; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Ujhelyi, Bernadett; Juhász, Béla; Általános Orvostudományi Kar::Szemészeti Tanszék; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézetpharmacological and non-pharmacological treatments for padiatric ophthalmological diseases focusing on myopia, amblyopia, glaucoma and retinopathy of prematurity.Tétel Korlátozottan hozzáférhető Current Pharmacological Approaches to treat Urinary Tract InfectionsMousavi, Seyedehazin; Varga, Balázs; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Dócs, János; Juhász, Béla; Általános Orvostudományi Kar::Urológiai Tanszék; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis thesis evaluates current therapeutic approaches to urinary tract infections, emphasizing optimized dosing and stewardship to combat multidrug-resistant pathogens. It distinguishes between infection types while addressing management needs for special populations. The work focuses on mitigating resistance through strategies like managing augmented renal clearance and the mutant selection window. Ultimately, it provides a vital framework for advancing antimicrobial stewardship in the face of rising resistance.Tétel Korlátozottan hozzáférhető Current pharmacology of thyroid drugsOmer, Saezar; Varga, Balázs; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Kiss, Rita; Fehér , Pálma; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Gyógyszerésztudományi Kar::Gyógyszertechnológiai TanszékThis thesis provides a comprehensive overview of the pharmacological management of thyroid disorders, focusing on both hypothyroidism and hyperthyroidism. It begins with the physiological and pathological basis of thyroid function, highlighting the role of thyroid hormones (T3 and T4) and the impact of autoimmune processes, iodine imbalance, and environmental factors. The core of the work examines current treatment strategies, particularly levothyroxine as the standard therapy for hypothyroidism, alongside alternative approaches such as liothyronine and combination T4/T3 therapy. It also evaluates antithyroid drugs like methimazole and propylthiouracil, including their mechanisms, clinical use, and safety profiles. Additional therapies such as iodide, beta-blockers, glucocorticoids, and radioiodine are discussed. The thesis further explores emerging treatments and advances in personalised medicine, emphasising the importance of an individualised, evidence-based approach to optimise outcomes and minimise adverse effects in patients with thyroid disease.Tétel Korlátozottan hozzáférhető Immunotherapy of Non-Small Cell Lung Cancer (NSCLC)Kairy, Dor; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetImmunotherapy of Non-Small Cell Lung Cancer (NSCLC)Tétel Korlátozottan hozzáférhető Modern Pharmacological Treatment Of DiabetesNavick, Amit; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dóra; Szentmiklósi, József; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetMy thesis is dealing with the different types of diabetes, their symptoms, risk factors, diagnostic criteria and complications. In addition it is focusing on the different pharmacotherapies and its application on different populations.Tétel Korlátozottan hozzáférhető Photodynamic Therapy of Acne and Acne ScarsTan , Jingqian; Gellén, Emese; Általános Orvostudományi Kar::Bőrgyógyászati Tanszék; DE--Általános Orvostudományi Kar; Sawhney, Irina; Pethó, Zsófia; Általános Orvostudományi Kar::Bőrgyógyászati Tanszék; Általános Orvostudományi Kar::Belgyógyászati Intézet::Reumatológiai TanszékThis thesis reviews the clinical evidence of photodynamic therapy (PDT) for acne vulgaris and acne scars, focusing on its efficacy, mechanisms, and safety. PDT improves acne by reducing inflammation, suppressing sebum production, and eliminating Cutibacterium acnes. It also benefits acne scars by promoting tissue regeneration, reducing hyperpigmentation, and regulating collagen synthesis. However, its effectiveness for severe scars is limited and often requires combination with other treatments. The review also compares different photosensitizers and light sources to optimize therapy. Overall, PDT is a safe and effective option, though further standardization is needed for consistent clinical use.Tétel Korlátozottan hozzáférhető The Impact of Non-Specific Skills on Endoscopic TraningNyante, Hugh; Farkas, Zsolt; Általános Orvostudományi Kar::Szülészeti és Nőgyógyászati Intézet; DE--Általános Orvostudományi Kar; Porszász, Róbert; Jashanjeet, Singh; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Szülészeti és Nőgyógyászati IntézetThe thesis examines the impact of non-specific skills such as psychomotor ability, spatial awareness, and cognitive adaptability on the acquisition of endoscopic skills within a dry laboratory training environment. It employs an experimental design comparing novice participants and medical residents,by grouping them by their level of non-specific skills and assessing performance through repeated laparoscopic tasks using time based metrics. The findings demonstrate that individuals with higher levels of non-specific skills perform tasks more efficiently, achieve faster completion times, and reach performance plateaus earlier than those with lower skill levels. Although medical residents show superior overall performance due to prior experience, novices with strong non-specific skills exhibit steeper learning curves, indicating rapid adaptability. The study highlights the significant role of non-specific skills in accelerating skill acquisition and improving consistency in endoscopic training. It concludes that integrating non-specific skill development into medical training and utilizing dry skills laboratories can enhance learning outcomes and improve procedural safety.Tétel Korlátozottan hozzáférhető New Frontiers in Lipid Management: The Role of Inclisiran in Cardiovascular Risk ReductionGabr, Mariem Wael Mohamed Abdelrahman; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetCardiovascular disease remains the leading cause of global mortality, with elevated LDL cholesterol identified as a key modifiable risk factor. Despite the availability of statins and other lipid lowering therapies, a significant proportion of high risk patients fail to reach guideline recommended LDL-C targets due to variable reasons. With continued research, novel therapeutic approaches targeting the PCSK9 pathway have emerged, most notably Inclisiran, the first approved siRNA based lipid lowering therapy. This thesis was written to review the biology of lipid metabolism and PCSK9, the mechanism of action of Inclisiran via RNA interference and hepatocyte selective delivery, and its clinical efficacy and safety as established through the ORION trial program, with a focus on its positioning relative to existing lipid lowering therapies as a potentially transformative advancement in cardiovascular risk management.Tétel Korlátozottan hozzáférhető Pharmacological Management of Opioid Use DisorderAbdalla, Rayana; Varga, Balázs; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Gesztelyi, Rudolf; Fenyvesi, Ferenc; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Gyógyszerésztudományi KarOpioid use disorder (OUD) remains a complex and escalating public health crisis, particularly in North America, driven by both historical overprescribing and the widespread availability of synthetic opioids such as fentanyl. This thesis critically examines the pharmacological management of OUD, focusing on the mechanisms, pharmacokinetics, and clinical application of methadone, buprenorphine, and naltrexone. Comparative analysis highlights important differences in safety, treatment retention, and accessibility, emphasizing the clinical advantages of opioid agonist therapies. Emerging therapies are also explored, though current evidence supports their role primarily as adjunctive options. Overall, this work underscores the importance of individualized treatment strategies and the integration of harm reduction approaches in improving patient outcomes.Tétel Korlátozottan hozzáférhető Management of neuromuscular blockade in paediatric patientsYousef Hussein Mustafa , Rasha; Mena Ajeeb , Boktor; Általános Orvostudományi Kar::Aneszteziológiai és Intenzív Terápiás Tanszék; DE--Általános Orvostudományi Kar; Gál, Judit; Fekete, Gábor Zoltán; Általános Orvostudományi Kar::Aneszteziológiai és Intenzív Terápiás Tanszék; Általános Orvostudományi Kar::Idegsebészeti KlinikaThis thesis highlights the history of anaesthesia, the challenges anaesthesiologists face, and the current guidelines for the management of NMBAs in paediatric patients. Emphasising the pharmacokinetic and pharmacodynamic differences between adult and paediatric patients. It also discusses commonly used NMBAs. It reviews the role of neuromuscular monitoring techniques, including acceleromyograph and electromyography, in minimising residual neuromuscular blockade. Additionally, the thesis explores the evolving role of reversal agents, such as sugammadex, compared to the regularly used anticholinesterasesTétel Korlátozottan hozzáférhető Pharmacology of Ganoderma lucidumSakamoto, Ryoya; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetPharmacological characteristics of Ganoderma lucidum nutrients were listed up and discussed. Specific components are as follow; polysaccharides, triterpenes, cerebrosides, peptides and polyphenols. Beneficial functions of each components were listed up. Anti-proliferative, immunomodulatory, antioxidative, anti-cancer, anti-microbial and anti-insomnia effects of the mushroom were discussed. Extracts of the mushroom may function as beneficial medicine, but there are few data of the effect of Ganoderma lucidum against human.Tétel Korlátozottan hozzáférhető Toxicological Investigation of Suicide Cases in Hungary and JapanSanada, Kazuki; Ráccz, Kálmán; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; DE--Általános Orvostudományi Kar; Pórszász, Róbert; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis examines the toxicological characteristics of suicide in Hungary and Japan, focusing on the substances involved and how patterns differ between the two countries. It shows that in Hungary, medication overdose—especially involving benzodiazepines, antidepressants, and antipsychotics—is the primary toxicological cause of suicide, often exacerbated by alcohol use. In contrast, Japan demonstrates a prominent role of gaseous methods such as carbon monoxide and hydrogen sulfide, although medication overdoses remain significant. The study highlights how cultural, social, and healthcare system differences—such as prescribing practices and access to means—influence suicide methods. It also identifies major challenges in forensic toxicology, including limited autopsy rates and difficulties in interpreting postmortem findings. Finally, the thesis proposes prevention strategies, emphasising safer prescribing, alcohol control, improved toxicological investigation, and coordinated public health interventions to reduce suicide mortality.Tétel Korlátozottan hozzáférhető Targeting Tau protein in Alzheimer's Disease: emergign pharmacological approachesIizuka, Yukiho; Porszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis is a literature review thesis about the emerging tau-targeted approaches in the treatment of Alzheimer's disease. Currently available conventional therapy only brings the symptomatic relief to the patients. However, the emerging tau-targeted approaches are focused due to its disease modifying potentials. Tau-targeted therapy can be divided into 3 categories, enzyme targeted therapy, tau aggregation therapy, and immunotherapy. this review also describes the limitation in the clinical translation of those approaches from experimental reserach.Tétel Korlátozottan hozzáférhető Contraceptives as Comprehensive Health CareKodama, Asuka; Varga, Balázs; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Kozma, Bence; Erdei, Tamás; Általános Orvostudományi Kar::Szülészeti és Nőgyógyászati Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis thesis explores oral contraceptive pills (OCPs) as both medical treatments and tools that influence women’s health, autonomy, and quality of life. It explains their pharmacological mechanisms, including how hormonal components prevent ovulation and create multiple barriers to fertilization, while also highlighting differences in formulations and delivery methods. Beyond contraception, the study emphasizes their therapeutic benefits, such as regulating menstrual cycles, improving conditions like acne and PCOS, and enhancing psychological well-being. The thesis also examines how cultural, systemic, and educational factors shape contraceptive use, with a particular comparison between Japan and Western countries, showing that access and social attitudes significantly affect uptake. It argues that OCPs should be viewed not only as birth control but as comprehensive healthcare tools that support reproductive autonomy and public health. Finally, the study calls for improved accessibility, better education, and more inclusive research to advance equitable contraceptive care worldwide.