Theses (Faculty of Medicine)
Állandó link (URI) ehhez a gyűjteményhez
Theses collection of the Faculty of Medicine. The collection was started in 2014.
At the University of Debrecen, in accordance with the 2022 amendment to the 2011 Higher Education Act, student theses are only accessible from devices connected to the University's Eduroam WiFi network or from a university IP address.
“The thesis or diploma work of a student who has successfully passed the final examination shall be stored in full in the academic system of the higher education institution, and a record shall be maintained thereof. The stored theses and diploma works – with the exception of parts classified as confidential in accordance with the relevant legislation – must be made accessible and searchable without restriction through the academic system.” Further info on the National Higher Education Act in Hungarian: Felsőokt. tv. (új) - 2011. évi CCIV. törvény a nemzeti felsőoktatásról - Hatályos Jogszabályok Gyűjteménye.
Böngészés
legfrissebb feltöltések
Megjelenítve 1 - 20 (Összesen 1833)
Tétel Korlátozottan hozzáférhető Current Pharmacological Therapy of Hepatic CarcinomaHsu, Shun-Chi; Varga, Balázs; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Juhász, Balázs Attila; Priksz, Dániel; Általános Orvostudományi Kar::Onkológiai Tanszék; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis thesis present an overview of hepatocellular carcinoma, covering its epidemiology, risk factors, staging systems, and diagnostic approaches, with a particular emphasis on pharmacological treatments.Tétel Korlátozottan hozzáférhető GLP-1 analogue in ObesityChoi , Kyu young; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézetthis paper discusses GLP-1 analogues. Initially known as antidiabetic agents, they have also been shown to be effective in weight loss. This paper describes drubs used to treat obesity and promote weight loss. Each drug's mechanism of action and weight loss effects are explained, along with any potential side effects.Tétel Korlátozottan hozzáférhető Therapeutic Applications of CannabisLee, Geun Hyang; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis explores the therapeutic applications of cannabis from multiple perspectives. It begins with a historical overview of how cannabis was used in ancient medicine and how it became illegal in the 20th century. Then, it explains the pharmacological mechanisms behind cannabinoids and its interaction with the human body. The paper also reviews the current medical evidence for using cannabis to treat various conditions, including chronic pain, neurological disorders, and rare forms of epilepsies. Finally, possible side effects, contraindications, and legal issues are discussed.Tétel Korlátozottan hozzáférhető Serotonergic phsychedelics in PTSD: Mechanisms of neuroplasticity and pharmacological actionZaman, Anta Ariana; Varga, Balázs; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Lekli, István; Bombicz, Mariann; Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis thesis explores the pharmacological mechanisms of serotonergic psychedelics, primarily psilocybin and MDMA, in relation to neuroplasticity and their potential to treat post-traumatic stress disorder (PTSD). It reviews neurobiological pathways, including 5-HT2A receptor stimulation and brain-derived neurotrophic factor (BDNF) up-regulation, supporting synaptic growth and fear extinction. The thesis compares these psychedelics with ketamine and highlights clinical trial outcomes showing promising symptom reduction with psychedelic-assisted psychotherapy. Ethical, regulatory, and safety considerations for clinical use are discussed, emphasising the need for trauma-informed therapeutic protocols. The work underscores neuroplasticity as a key therapeutic target while calling for further PTSD-specific clinical research to establish treatment durability.Tétel Korlátozottan hozzáférhető Cerebral Aneurysms - A Review of Pathology and PathophysiologyArora, Simran; Szabó, Sándor; Általános Orvostudományi Kar::Idegsebészeti Klinika; DE--Általános Orvostudományi Kar; Gál, Judit; Fekete, Gábor; Általános Orvostudományi Kar::Aneszteziológiai és Intenzív Terápiás Tanszék; Általános Orvostudományi Kar::Idegsebészeti KlinikaThis manuscript provides a comprehensive review of intracranial aneurysms (IA), covering their prevalence, epidemiology, and pathogenesis, as well as the risk factors that contribute to aneurysm rupture. It examines the clinical presentation, diagnosis, and critical care management of aneurysmal subarachnoid hemorrhage (aSAH), emphasizing strategies to prevent early and delayed complications. The paper also explores the pathophysiology, classification, and modern understanding of vasospasm and delayed cerebral ischemia (DCI), highlighting recent advances in monitoring and therapeutic interventions aimed at reducing neurological damage and improving long-term outcomes after IA rupture.Tétel Korlátozottan hozzáférhető Conventional and Modern Treatment Options in Parkinson's DiseaseSigurðardóttir, Freyja Sólrún; Szentmiklósi, András József; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi, Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetParkinson's disease (PD) is the second most common neurodegenerative disorder in the world, having doubled in prevalence in the past 25 years. Conventional treatment options primarily alleviate the motor symptoms of the disease, with relatively little impact on the non-motor symptoms. Furthermore, they are symptomatic treatments that do not alter, slow, or cure the disease. Consequently, there is a growing interest in novel therapeutic approaches that target the underlying disease mechanisms, including gene therapy, stem cell transplantation, high-intensity focused ultrasound (HIFU), and neuroprotective agents. By comparing the efficacy, safety, and limitations of both conventional and novel therapies, this work aims to provide a comprehensive understanding of current and future treatment options for Parkinson’s disease.Tétel Korlátozottan hozzáférhető Pharmacological management of preeclampsiaAbdelwahab , Aya; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézetthesis explores preeclampsia as a major hypertensive disorder of pregnancy causing high maternal and fetal morbidity and mortality. It explains that abnormal placentation, oxidative stress, and immune imbalance drive the disease. Diagnostic criteria from ACOG and ISSHP are outlined alongside clinical features and complications like HELLP syndrome. The core focus is on pharmacologic management, including labetalol, nifedipine, methyldopa, hydralazine, and magnesium sulfate. Corticosteroids for fetal lung maturity and postpartum monitoring are also discussed. The thesis concludes by emphasizing early detection, individualized care, and the need for improved therapeutic strategies.Tétel Korlátozottan hozzáférhető Biological Treatment Options in Ulcerative Colitis TherapyFriedman, Dar Liba; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dóra; Megyeri, Attila; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetUlcerative colitis (UC) is a chronic inflammatory bowel disease that affects the colon and the rectum. Numerous factors, including genetic, environmental, luminal, and mucosal immune dysregulation, have been proposed as potential contributors to the pathophysiology of this disease, which has an unclear etiology. It has been demonstrated that developed nations have a higher incidence of the disease. Advances in medicine and new innovative treatments have enabled a paradigm shift, in treatment goals from symptomatic relief to endoscopic and histological healing to achieve improved long-term outcomes and maintain remission. Over the past two decades, the options for medical therapy have expanded and today include biologics and small molecules. In addition to biological therapy, conventional therapeutic approaches are used to control the exacerbated host immune response. A protein or gene that is present in the body is employed as the "target" in biological treatments. Human cells are used to extract and isolate recombinant DNA, which is then modified. To express the desired gene product, the modified segment is introduced into a vector. TNF-alpha, Integrin receptor and JAK intracellular protein (mostly JAK1) are potential targets in UC. These proteins and cytokines are crucial in the development and progression of inflammation, thus novel biological therapies aim to target these molecules. Additionally, non-biological pharmacological treatments for UC may encompass the use of different drug classes such as, glucocorticoids, aminosalicylates, and immunomodulators.Tétel Korlátozottan hozzáférhető Psilocybin as a Treatment for DepressionKahraman, Arif Ersegün; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dóra; Megyeri, Attila; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis thesis explores the re-emergence of psilocybin as a promising treatment for depression. It examines psilocybin’s historical use, pharmacological action on 5-HT₂A receptors, and its effects on neuroplasticity and cognition. Key clinical trials are reviewed, highlighting rapid and sustained therapeutic benefits in controlled settings, along with safety considerations and ethical implications. The study concludes that psilocybin, with proper safeguards, could represent a transformative approach in psychiatric care, warranting further large-scale research.Tétel Korlátozottan hozzáférhető IMMUNIZATION IN UGANDA BETWEEN 1989 and 2024KABASWEEKA , DIANA; Pál, László; Általános Orvostudományi Kar::Népegészség-és Járványtani Intézet; DE--Általános Orvostudományi Kar; Fűzi, Márta; Lovas, Szabolcs; Általános Orvostudományi Kar::Magatartástudományi Intézet; Általános Orvostudományi Kar::Népegészség-és Járványtani IntézetThis thesis evaluates Ugandas immunization programs and how they have affected vaccination coverage compared to Africa and EuropeTétel Korlátozottan hozzáférhető Recent advances in pharmacotherapy of biliary tract cancerDashti, Banafsheh; Megyeri, Attila; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dóra; Szentmiklósi, József; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetBiliary tract cancer (BTC) is a rare but highly aggressive malignancy arising from the bile ducts and gallbladder. Despite advances in diagnostic imaging and surgical techniques, most cases are diagnosed at an advanced stage, limiting curative options. Pharmacotherapy remains the mainstay of treatment for unresectable or metastatic disease. Recent developments in chemotherapy, targeted therapy, and immunotherapy have significantly improved patient outcomes and survival rates. Molecular profiling has led to the identification of actionable mutations, enabling personalized treatment approaches. Continued research into novel agents and combination therapies holds promise for further progress in the management of biliary tract cancer.Tétel Korlátozottan hozzáférhető Pharmacology of CAR T-cell TherapySarkar, Akash; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi , Barbara Dóra; Halasi , Dóra Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetChimeric Antigen Receptor T-cell (CAR T-cell) therapy has proven to be a major advancement in the field of cancer immunotherapy, providing promising clinical outcomes in the treatment of certain hematological malignancies, where standard treatment modalities such as chemotherapy and hematopoietic stem cell transplantation (HSCT) often fall short. In CAR T-cell therapy, a patient’s own T-cells are collected and isolated and genetically engineering them recognize antigens on tumor cells such as CD19 or BCMA, bypassing the need to bind to the major histocompatibility complex (MHCI) which normally presents antigens to CD8+ cytotoxic T-cells (CTLs). This allows for the direct activation of the CAR T-cells and subsequent tumor cell lysis. Clinical trials and studies have shown high remission and survival rates even in case of relapsed or refractory B-cell malignancies. Despite their success, they face challenges such as the development of toxicity syndromes such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), as well as manufacturing complexity, high costs and limited accessibility. To tackle some of these limitations, research is ongoing and includes the development of newer generation of CARs to expand its indications, allogeneic CARs from donors, as well as combining it with standard therapies and other drugs to improve its efficacy.Tétel Korlátozottan hozzáférhető Post Traumatic Stress Disorder and Post Traumatic GrowthChahal, Pardeep; Morvai, Szabolcs; Általános Orvostudományi Kar::Pszichiátriai Tanszék; DE--Általános Orvostudományi Kar; Andrási, Gábor; Hidasi, Eszter; Általános Orvostudományi Kar::Pszichiátriai Tanszék; Általános Orvostudományi Kar::Neurológiai TanszékThis thesis explores how Post-Traumatic Stress Disorder (PTSD), which can seriously affect mental health after traumatic experiences, interacts with Post-Traumatic Growth (PTG). PTG involves positive changes like a deeper appreciation for life and stronger relationships that can happen after dealing with adversity. The study uses a mixed-methods approach to look at data from 200 trauma survivors—these include military veterans, people who’ve faced natural disasters, those involved in car accidents, and victims of violent crimes. It employs quantitative methods such as the PTSD Checklist (PCL-5) and the Post-Traumatic Growth Inventory (PTGI), along with thematic analysis from 25 semi-structured interviews. The results indicate that PTSD and PTG can coexist; in fact, PTG can develop even when PTSD symptoms are present, especially if there are protective factors in place like social support, effective coping strategies (like problem-solving and finding meaning), and intentional cognitive processing. This research also shows that the severity of trauma can predict levels of PTG, which challenges the conventional belief that trauma is purely harmful. It highlights the potential for personal growth following difficult experiences. Additionally, it points out the importance of personality traits like optimism and resilience, as well as cultural and religious factors, in encouraging growth. Ultimately, the thesis suggests that therapeutic approaches should incorporate cognitive reframing and social support to help lessen PTSD symptoms while promoting holistic recovery and long-term wellness.Tétel Korlátozottan hozzáférhető Pharmacological Therapy Of Acne VulgarisAl-obaidi, Zahraa; Pórszász , Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklosi, József; Halasi, Barbara Dóra; Halasi, Barbara Dora; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThe thesis titled “Pharmacological Therapy of Acne Vulgaris” explores the causes, types, and modern treatments of acne. It describes acne as a persistent inflammatory disorder of the skin’s pilosebaceous unit, mainly influenced by hormones, bacteria, and immune activity. The research reviews both topical medications—such as retinoids, benzoyl peroxide, and antibiotics—and systemic options, including oral antibiotics, hormonal agents, and isotretinoin, with attention to their actions and side effects. It emphasizes the value of evidence-based, personalized therapy guided by international recommendations. The study also addresses treatment considerations during pregnancy, the emotional and psychological burden of acne, and the issue of antibiotic resistance. Finally, it highlights innovative approaches like microbiome-focused therapy, probiotics, and nanotechnology as promising directions for future acne management.Tétel Korlátozottan hozzáférhető Pregnancy Outcomes in Terminally Ill Women and Its ManagementJovia Nabukenya, Nakaye; Singh, Jashanjeet; Általános Orvostudományi Kar::Szülészeti és Nőgyógyászati Intézet; DE--Általános Orvostudományi Kar; Virga, József; Krasnyánszky, Nóra; Általános Orvostudományi Kar::Onkológiai Tanszék; Általános Orvostudományi Kar::Szülészeti és Nőgyógyászati IntézetThe thesis primarily focuses on the management of cancers during pregnancy, a condition affecting approximately 1 in 1,000 to 1 in 2,000 pregnancies, which is becoming more prevalent due to an increase in maternal age. It focuses on the diagnosis, management and outcomes of the five most common malignancies: breast, cervical, melanoma, haematological and ovarian cancers. The core dilemma lies in the 'maternal–fetal conflict', whereby optimal oncological treatment for the mother must be balanced against minimising risks to the fetus. This is particularly challenging given that diagnosis is often delayed because cancer symptoms mimic normal pregnancy changes. Treatment protocols must be carefully timed: chemotherapy is strictly contraindicated during the first trimester due to the high risk of congenital malformations (up to 20%), but is considered relatively safe during the second and third trimesters. Radiation therapy and targeted therapies are generally avoided. While maternal remission rates are often similar to those of non-pregnant patients, fetal outcomes are subject for concern, with common complications including high rates of preterm delivery.Tétel Korlátozottan hozzáférhető Medical uses of herbal remediesRees, Sarah Ruth; Szentmiklósi, András József; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi, Barbara; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis thesis explores the therapeutic potential of herbal remedies in treating various diseases. Cinnamon, garlic, Ganoderma lucidum, myrrh, and hawthorn were examined for their bioactive compounds and health benefits. Cinnamon was shown to lower blood sugar and support cardiovascular and neuroprotective health. Garlic demonstrated antimicrobial, antioxidant, and anti-cancer properties, contributing to cardiovascular and metabolic improvements. Ganoderma lucidum and myrrh exhibited anti-inflammatory and anti-cancer effects, while hawthorn supported cardiovascular, digestive, and neurological health. Overall, these herbal medicines offer promising alternatives or complements to conventional treatments for chronic conditions.Tétel Korlátozottan hozzáférhető Pharmacological Tools in the Management of Neurodegenerative DisordersLe , Bao Lam Quynh; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetNeurodegenerative diseases, such as Alzheimer’s and Parkinson’s, are characterized by neuronal loss. Treatment involves acetylcholinesterase and NMDA inhibitors like rivastigmine, galantamine, donepezil, and memantine for symptomatic relief. Additionally, herbal remedies like gintonin show promise in managing these conditions. Recent advancements include multitarget drugs like hypridone and bis (3)-Cognitin, which inhibit both acetylcholinesterase and MAO-B, reducing plaque accumulation and oxidative stress. Emerging techniques like siRNA targeting pathogenic proteins aim to influence mRNA stability and inhibit aberrant protein formation, offering new therapeutic avenues.Tétel Korlátozottan hozzáférhető Treatment Options in Triple Negative Breast CancerAgana, Stephanie; Szekeres, Réka; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Kiss, Rita; Gaál, Botond; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Anatómiai, Szövet- és Fejlődéstani IntézetTriple-Negative Breast Cancer (TNBC) is a subtype of breast cancer that tests negative for estrogen receptor, progesterone receptor, and human epidermal growth factor-2 receptor (HER2), according to the American Cancer Society. It remains one of the most aggressive subtypes of breast cancer. The main risk factor of this disease is the use of oral contraceptives in younger women (less than 50 years old) for longer than one year. The standard of care for TNBC remains chemotherapy. Other treatment options that have proven to improve overall survival include Surgery, radiotherapy, immunotherapy, targeted therapy, and antibody-drug conjugates. Several clinical trials are still ongoing to develop more effective and targeted treatments that improve survival and reduce the toxicity profile.Tétel Korlátozottan hozzáférhető New Advances in the Antiepileptic Drug DevelopmentPark, Sangwoo; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi , Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetEpilepsy affects millions worldwide, causing seizures and significant neurological, psychological, and social impacts. Traditional antiepileptic drugs (AEDs) help many patients, but about one-third still suffer from drug-resistant epilepsy. Current AEDs mainly suppress excitability through sodium, calcium, or GABA pathways, yet they do not cure the disease and often cause side effects. New therapies, including selective modulators (PRAX-628, QO-83), neuroactive steroids (LPM682000012), gene therapies (AMT-260), and cannabidiol analogues, show promise in overcoming these limits. Advances in AI, pharmacogenomics, and biomarkers are driving a shift toward personalized, effective, and potentially curative treatments.Tétel Korlátozottan hozzáférhető Diagnosis and treatment of Chronic UrticaraAl Shaka, Hussein Mostafa; Gáspár, Krisztián; Általános Orvostudományi Kar::Bőrgyógyászati Tanszék; DE--Általános Orvostudományi Kar; Griger, Zoltán; Szabó, Imre Lőrinc; Általános Orvostudományi Kar::Belgyógyászati Intézet; Általános Orvostudományi Kar::Bőrgyógyászati TanszékThis thesis is about a General overview of Chronic Urticaria and it's different subtypes, It also includes Diagnosis, differential diagnosis and treatment of this chronic illness. Chronic Urticaria is a disease defined as the presence of wheals/ hives Or angioedema Or both for a period that spans more than 6 weeks. This works dives into the sub-classification of Chronic urticaria such as Chronic spontaneous urticaria and Chronic inducible urticaria with it's many sub-types including: Cold, heat, pressure, cholinergic and dermographism ( Urticaria factitia). It also includes the role of genetics, it's etiology and different factors that influences the disease. with an end summary on most used treatment for this chronic illness including first line - third line treatment and immerging/ possible new treatment's that patients can course through while having this condition